Effect of Inhalation Rate on Insulin AUC and Cmax

1
Effect of Inhalation Rate on Insulin AUC and Cmax
Study Target Inhalation Rate (L/min) Actual Inhalation Rate (L/min) AUC Cmax
217-011 10 14.5 ? 40 ? 50
25 (Standard) 29.3 - -
gt35 40.3 ? 20 ? 4
217-019 10 8.8 ? 2 ? 4
25 (Standard) 14.1 - -
Relative to Standard Inhalation Rate (25 L/min)
Slower inhalation rates tend to increase AUC and
Cmax while faster inhalation rates decrease AUC
and Cmax
CP57
2
Mean of Replicate AUC0-600 by Subject (Study
A2171012)
CP124
3
Insulin Pulmonary Inhaler
CP166