EXTRACTING ARTERIAL BLOOD CURVE FROM PET IMAGE

1
EXTRACTING ARTERIAL BLOOD CURVE FROM PET IMAGE

• Images containing abdominal aorta

2
why

• missing blood data
• noninvasive alternative
• high costs of arterial sampling
• other problems with arterial sampling
• more reliable than arterialised venous sampling

3
method - what are we fitting

• only once
• diameter of the vessel (needs initial value)
• for all frames separately
• center of the vessel
• activity inside vessel
• activity of the surrounding area

4
how

• Known
• CIactivity in PET image
• Unknown
• CBfinal input TAC
• CBGbackground activity
• CAactivity inside arteria
• CI(CA-CBG)KCBG
• gt

K
distance from the centre of vessel
5
Adipose tissue study
6
problems ideas

• results are very dependent on diameter value
• 2D convolution might be used for testing

7
References

• Germano et al. Use of Abdominal Aorta for
  Arterial Input Function Determination in Hepatic
  and Renal PET Studies J Nucl Med 1992 33613-620