Taxanes

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Taxanes  Taxanes are among the most active
agents for metastatic breast cancer Docetaxel,
Paclitaxel, NabPaclitaxel. Anthracyclines
Doxorubicin, Epirubicin, Caelyx. Capecitabine / 5
FU Eribulin Vinorelbine Gemcitabine Ixabepilone Et
oposide Cyclophosphamide Methotrexate Platinum
agents Combination Chemotherapy High Dose
Chemotherapy and Stem Cell Transplant no
benefit.
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Common Adjuvant Regimens
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First Generation ? Second Generation ? Third Generation
CMF6 ? CAF6, CEF6
CMF6 ? FAC6 ? TAC6
CE(50)F6 ? CE(100)F6 ? FEC3?D3
AC4 ? AC4?Txl4 q3wk ? Dose Dense (CA4?Txl4 q2wk)
AC4 ? TC4

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Doxorubicin 60 mg/m2 IV Day 1 Cyclophosphamide
600 mg/m2 IV Day 1 Every 21 days x 4 cycles
RANDOMIZE
Docetaxel 75 mg/m2 IV Day 1 Cyclophosphamide 60
0 mg/m2 IV Day 1 Every 21 days x 4 cycles
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2nd Generation Adjuvant Chemo Trials
First Generation ? Second Generation ? Third Generation
CMF6 ? CAF6, CEF6
CMF6 ? FAC6 ? TAC6
CE(50)F6 ? CE(100)F6 ? FEC3?D3
AC4 ? AC4?Txl4 q3wk ? Dose Dense (CA4?Txl4 q2wk)
AC4 ? TC4

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Whats the Goal?

• Select patients who will require systemic therapy
  
• Find predictive factors (either before or early
  in treatment) that allow for accurate tailoring
  of therapy

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