Survey Results

1
Survey Results analysis for

• ATS Assembly on Respiratory Structure Function
  Project Proposal Initiative

2
Executive Summary
This report contains a detailed statistical analysis of the results to the survey titled ATS Assembly on Respiratory Structure Function Project Proposal Initiative . The results analysis includes answers from all respondents who took the survey in the 70 day period from Tuesday, May 12, 2009 to Monday, July 20, 2009. 71 completed responses were received to the survey during this time.
Survey Results Analysis
Survey ATS Assembly on Respiratory Structure Function Project Proposal Initiative
Author
Filter
Responses Received 71
3
Provide up to three suggestions for existing or
new areas of significant importance or
controversy that you feel should be considered
for project development
1 2 3
Ventilation/Persusion in artificial ventilation - heterogeneity of perfusion as a cause of hypoventilation a forgotten issue Effects of air pollution (physical, chemical, biological) on airway/parenchyma structure and remodeling  
Exhaled breath analysis for desese diagnosis. Innovations in technology that may have utlity in the meidical field. Update on Methacholine challenge testing
Transcriptional mechanisms of recovery from acute lung injury Altered surfactant metabolism in diseased lung lung morphogenesis
Respiratory Health Effects of Climate Change The mechanisms and role of airway nerves in airway diseases.  
Exhaled breath analysis for disease diagnosis. Innovations in technology that will have future utility in the medical field. Update on Methacholine challenge testing
lung repair in COPD    
Severe asthma pathogenesis and new treatments Airway Smooth Muscle Cells anf Myofibroblasts as targets for treating asthma and COPD  
4
Phenotyping of animal models of emphysema Quantitative lung imaging Alveolar cell and tissue mechanics
pulmonary vasculopathy in metabolic diseaseacute vs chronic inflammatory response pulmonary vascular response to inflammatory damage regio-temporal specific "hot spots" cytoskeletal microdomains in endothelial repair
Functional consequences of airway smooth muscle remodeling    
Origins of increased smooth muscle in asthma. Clinical trial of inhaled corticosteroids on airway smooth muscle hyperplasia. Airway smooth muscle hypertrophy or hyperplasia in COPD.
The significance of the small airways in asthma measurement, phenotypes treatment.    
Complex behavior of the respiratory system in health and disease    
Cyclical recruitment of atelectasis as a mechanism of ventilator-associated lung injury    
exhaled breath analysis    
5
oral-cavity interferences with measurements of exhaled trace constituents from airways    
Role of extracellular matrix in airway hyperesponsiveness    
Airway epithelial barrier function in health and disease Airway epithelial models of health and disease  
Airway Acid and Oxidative Stress--Biochemical Impacts on Airway Function    
complex in vitro models epithelial/endothelial, Epithelial/smooth muscle, Epithelial/leukocyte    
Interaction of nanoparticles with biological systems and subsequent effects - interaction with the lung, lung tissue and lung cells Electron tomography - 3D electron microscopy interaction of nanoparticles with subcellular structures like cytoskeleton, organelles, the nucleus Nanoparticulate matter in pulmonary medicinal application diagnistics, therapeutics (nanomedicine)
miRNA in lung function and airway remodeling    
Dynamics of oxygen delivery Gas equation and it's clinical relation Atelectasis and it's management in context of mechanical ventilation
COPD rehabilitation screening upper mechanics for OSA neuromuscular/chest wall disorders
6
severe asthma phenotypes animal models for rare pulmonary diseases therapeutic targets in chronic cough
MODULATION OF SMALL AIRWAY INFLAMMATION IN ASTHMA WITH EXISTING NEWER INHALERS INFLUENCE OF VARIOUS BREATHING MANOUVERS ON AIRWAY CALIBRE INCLUDING YOGIC BREATHING WHICH HAS IMMENSE POTENTIAL WHICH HAS NOT BEEN ADDRESSED YET. VARIABILITY IN ACUTE LUNG INJURY DUE TO DIFFERENT ETIOLOGICAL FACTORS , SEPSIS IN PARTICULAR
Cardiopulmonary exercise capacity in obesity. Typical reporting may mask the fact that many obese are not deconditioned but rather symptomatic. A position document would be very helpful in the area. Obesity and respiratory function at rest and during exercise. Also, dyspnea on exertion.  
Tracheostomies in children - standards of care for ongoing management, bronchoscopy etc    
Dyspnea - more than altered mechanics    
Obesity Respiratory Muscles  
lung development in the extremely premature neonate, ventilation strategies for these patients    
In vitro modelling of healthy airways In vitro respiratory drug delivery and testing  
7
endothelial dysfuction in ARDS endothelial pathophysiology in pulmonary hypertension pulmonary circulation in ventilator injury
ATS Methacholine Challange Guideline Update. last was is 1999 Pulmonary Physiology in the 21st century Innovations in testing and design. Exhaled Breath measurement for Disease. We had previouslt published a paper on detecting Lung cancer. Now we are looking at all disease. This I would like to chair as I have the background and expertise.
Lung residenet stem cells inducible prluripotent stem cells microparticles
Animal models of emphysema Innate immune function in COPD  
Interaction of inflammatory and alveolar epithelial cells in acute lung injury The role of programmed cellular death in response to stress in resident lung cells  
stem cell research effect of nanoparticles in health and disease  
Pulmonary nontuberculous mycobacterial disease    
x-dr tuberculosis ARDS MULTIRESISTANT ORGANISMS IN VAP
Steroid resistance in structural cells Glucocorticoid signaling Alternative therapy in Severe asthma
New metabolic or lipid pathways that could modulate airway remodeling. Statins and airway disease.  
Air pollution and lung (dys)function Lung parenchymal structural components how do they modify function Better understanting FOT and IOS data
8
The controversial role of RAGE in lung pathophysiology. Queisser MA et al.,Am J Respir Cell Mol Biol. 2008 Sep39(3)337-45 Reynolds PR et al.,Am J Respir Cell Mol Biol. 2009 Jun 25 Sternberg DI et al., J Thorac Cardiovasc Surg. 2008 Dec136(6)1576-85 Englert JM et al., Am J Pathol. 2008 Mar172(3)583-91 He M et al., Am J Physiol Lung Cell Mol Physiol. 2007 Dec293(6)L1427-36. Mechanisms of alveolar protein clearance in the intact lung Am J Physiol Lung Cell Mol Physiol. 2004 Apr286(4)L679-89. Review  
The development of airway smooth muscle in utero and early life. Factors influencing cell number. The composition of the ectracellular matrix in asthma.  
Role of imaging in lung disease Translation of new technologies to clinical practice Standards for performance for diagnostic and monitoring tools in critical care
Airway wall remodelling Signal transduction cascades underlying development and severity of airway diseases Airway hyperresponsiveness mechanisms and consequences
Airway smooth muscle as a major actor in airway hyperresponsiveness from whole muscle mechanics to the assesment of crossbridge properties. Statistical mechanics a new way to establish a link between microscopic properties of airway smooth muscle and its bulk mechanical properties.  
Murine and other animal models of COPD Modeling airway hyperresponsiveness Aging and the lung
9
1. (Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development)
10
1.
Ventilation/Persusion in artificial ventilation - heterogeneity of perfusion as a cause of hypoventilation a forgotten issue
Exhaled breath analysis for desese diagnosis.
Transcriptional mechanisms of recovery from acute lung injury
Respiratory Health Effects of Climate Change
Exhaled breath analysis for disease diagnosis.
lung repair in COPD
Severe asthma pathogenesis and new treatments
Phenotyping of animal models of emphysema
pulmonary vasculopathy in metabolic diseaseacute vs chronic inflammatory response
Functional consequences of airway smooth muscle remodeling
Origins of increased smooth muscle in asthma.
The significance of the small airways in asthma measurement, phenotypes treatment.
Complex behavior of the respiratory system in health and disease
Cyclical recruitment of atelectasis as a mechanism of ventilator-associated lung injury
exhaled breath analysis
oral-cavity interferences with measurements of exhaled trace constituents from airways
Role of extracellular matrix in airway hyperesponsiveness
Airway epithelial barrier function in health and disease
Airway Acid and Oxidative Stress--Biochemical Impacts on Airway Function
complex in vitro models epithelial/endothelial, Epithelial/smooth muscle, Epithelial/leukocyte
Interaction of nanoparticles with biological systems and subsequent effects - interaction with the lung, lung tissue and lung cells
miRNA in lung function and airway remodeling
11
Dynamics of oxygen delivery
COPD rehabilitation
severe asthma phenotypes
MODULATION OF SMALL AIRWAY INFLAMMATION IN ASTHMA WITH EXISTING NEWER INHALERS
Cardiopulmonary exercise capacity in obesity. Typical reporting may mask the fact that many obese are not deconditioned but rather symptomatic. A position document would be very helpful in the area.
Tracheostomies in children - standards of care for ongoing management, bronchoscopy etc
Dyspnea - more than altered mechanics
Obesity
lung development in the extremely premature neonate, ventilation strategies for these patients
In vitro modelling of healthy airways
endothelial dysfuction in ARDS
ATS Methacholine Challange Guideline Update. last was is 1999
Lung residenet stem cells
Animal models of emphysema
Interaction of inflammatory and alveolar epithelial cells in acute lung injury
stem cell research
Pulmonary nontuberculous mycobacterial disease
x-dr tuberculosis
Steroid resistance in structural cells
New metabolic or lipid pathways that could modulate airway remodeling.
Air pollution and lung (dys)function
12
The controversial role of RAGE in lung pathophysiology. Queisser MA et al.,Am J Respir Cell Mol Biol. 2008 Sep39(3)337-45 Reynolds PR et al.,Am J Respir Cell Mol Biol. 2009 Jun 25 Sternberg DI et al., J Thorac Cardiovasc Surg. 2008 Dec136(6)1576-85 Englert JM et al., Am J Pathol. 2008 Mar172(3)583-91 He M et al., Am J Physiol Lung Cell Mol Physiol. 2007 Dec293(6)L1427-36.
The development of airway smooth muscle in utero and early life. Factors influencing cell number.
Role of imaging in lung disease
Airway wall remodelling
Airway smooth muscle as a major actor in airway hyperresponsiveness from whole muscle mechanics to the assesment of crossbridge properties.
Murine and other animal models of COPD
13
(No Transcript)
14
Glucocorticoid signaling
Statins and airway disease.
Lung parenchymal structural components how do
they modify function
Mechanisms of alveolar protein clearance in the
intact lung Am J Physiol Lung Cell Mol Physiol.
2004 Apr286(4)L679-89. Review
The composition of the ectracellular matrix in
asthma.
Translation of new technologies to clinical
practice
Signal transduction cascades underlying
development and severity of airway diseases
Statistical mechanics a new way to establish a
link between microscopic properties of airway
smooth muscle and its bulk mechanical properties.
Modeling airway hyperresponsiveness
15
3. (Provide up to three suggestions for existing or new areas of significant importance or controversy that you feel should be considered for project development)
16
3.
Update on Methacholine challenge testing
lung morphogenesis
Update on Methacholine challenge testing
Alveolar cell and tissue mechanics
cytoskeletal microdomains in endothelial repair
Airway smooth muscle hypertrophy or hyperplasia in COPD.
Nanoparticulate matter in pulmonary medicinal application diagnistics, therapeutics (nanomedicine)
Atelectasis and it's management in context of mechanical ventilation
neuromuscular/chest wall disorders
therapeutic targets in chronic cough
VARIABILITY IN ACUTE LUNG INJURY DUE TO DIFFERENT ETIOLOGICAL FACTORS , SEPSIS IN PARTICULAR
pulmonary circulation in ventilator injury
Exhaled Breath measurement for Disease. We had previouslt published a paper on detecting Lung cancer. Now we are looking at all disease. This I would like to chair as I have the background and expertise.
microparticles
MULTIRESISTANT ORGANISMS IN VAP
Alternative therapy in Severe asthma
Better understanting FOT and IOS data
Standards for performance for diagnostic and monitoring tools in critical care
Airway hyperresponsiveness mechanisms and consequences
Aging and the lung
Acute Lung Injury
17
Most Desirable Desirable Somewhat Desirable Not Desirable Least Desirable
Cytoskeletal dynamics in lung health and disease 25.4 (16) 30.2 (19) 28.6 (18) 7.9 (5) 7.9 (5)
Immune response in ventilator-injured lungs 14.3 (9) 38.1 (24) 23.8 (15) 15.9 (10) 7.9 (5)
Advances in ventilator technology and modalities 15.9 (10) 17.5 (11) 42.9 (27) 14.3 (9) 9.5 (6)
Osmotic stress and lung injury repair 6.3 (4) 28.6 (18) 39.7 (25) 14.3 (9) 11.1 (7)
18
Cytoskeletal dynamics in lung health and disease(Acute Lung Injury)
19
Immune response in ventilator-injured lungs(Acute Lung Injury)
20
Advances in ventilator technology and modalities(Acute Lung Injury)
21
Osmotic stress and lung injury repair(Acute Lung Injury)
22
Lung (Patho)Physiology and Mechanics
23
Most Desirable Desirable Somewhat Desirable Not Desirable Least Desirable
Murine models of asthma strengths, weaknesses, opportunities and threats 16.7 (11) 40.9 (27) 25.8 (17) 9.1 (6) 7.6 (5)
Neural control of the airways 15.4 (10) 29.2 (19) 40.0 (26) 13.8 (9) 1.5 (1)
Modulation of the cough reflex 13.8 (9) 24.6 (16) 36.9 (24) 16.9 (11) 7.7 (5)
TRP channels in airway pathobiology 8.1 (5) 19.4 (12) 43.5 (27) 24.2 (15) 4.8 (3)
Quantifying emphysema in humans and mice 34.8 (23) 19.7 (13) 33.3 (22) 10.6 (7) 1.5 (1)
Neuropeptide modulation airway mechanics in asthma 8.3 (5) 30.0 (18) 43.3 (26) 15.0 (9) 3.3 (2)
Influence of the epithelium on airway calibre 23.4 (15) 46.9 (30) 20.3 (13) 6.3 (4) 3.1 (2)
Small airway function inflammation, airway calibre and heterogeneity 35.4 (23) 47.7 (31) 12.3 (8) 4.6 (3) 0.0 (0)
Airway hyperresponsiveness molecules to man 36.9 (24) 35.4 (23) 20.0 (13) 6.2 (4) 1.5 (1)
Role of lung surfactant in modulating airway mechanics in asthma 15.9 (10) 38.1 (24) 30.2 (19) 11.1 (7) 4.8 (3)
24
Gender differences in health, aging and lung disease 13.4 (9) 34.3 (23) 31.3 (21) 16.4 (11) 4.5 (3)
Vascular barrier properties 8.1 (5) 25.8 (16) 43.5 (27) 14.5 (9) 8.1 (5)
Interstitial matrix molecules and tissue mechanics 18.3 (11) 40.0 (24) 25.0 (15) 10.0 (6) 6.7 (4)
Use of the forced oscillation technique 7.7 (5) 24.6 (16) 32.3 (21) 20.0 (13) 15.4 (10)
Severe asthma causes, consequences and treatment 41.5 (27) 27.7 (18) 18.5 (12) 9.2 (6) 3.1 (2)
Pathobiology of rare lung diseases 12.3 (8) 18.5 (12) 33.8 (22) 23.1 (15) 12.3 (8)
Aging of the pulmonary system 28.6 (20) 41.4 (29) 18.6 (13) 8.6 (6) 2.9 (2)
25
Murine models of asthma strengths, weaknesses, opportunities and threats(Lung (Patho)Physiology and Mechanics)
26
Neural control of the airways(Lung (Patho)Physiology and Mechanics)
27
Modulation of the cough reflex(Lung (Patho)Physiology and Mechanics)
28
TRP channels in airway pathobiology(Lung (Patho)Physiology and Mechanics)
29
Quantifying emphysema in humans and mice(Lung (Patho)Physiology and Mechanics)
30
Neuropeptide modulation airway mechanics in asthma(Lung (Patho)Physiology and Mechanics)
31
Influence of the epithelium on airway calibre(Lung (Patho)Physiology and Mechanics)
32
Small airway function inflammation, airway calibre and heterogeneity(Lung (Patho)Physiology and Mechanics)
33
Airway hyperresponsiveness molecules to man(Lung (Patho)Physiology and Mechanics)
34
Role of lung surfactant in modulating airway mechanics in asthma(Lung (Patho)Physiology and Mechanics)
35
Gender differences in health, aging and lung disease(Lung (Patho)Physiology and Mechanics)
36
Vascular barrier properties(Lung (Patho)Physiology and Mechanics)
37
Interstitial matrix molecules and tissue mechanics(Lung (Patho)Physiology and Mechanics)
38
Use of the forced oscillation technique(Lung (Patho)Physiology and Mechanics)
39
Severe asthma causes, consequences and treatment(Lung (Patho)Physiology and Mechanics)
40
Pathobiology of rare lung diseases(Lung (Patho)Physiology and Mechanics)
41
Aging of the pulmonary system(Lung (Patho)Physiology and Mechanics)
42
Airway Smooth Muscle Airway Remodeling
43
Most Desirable Desirable Somewhat Desirable Not Desirable Least Desirable
Developing in vivo methods for measuring airway remodeling 35.9 (23) 35.9 (23) 18.8 (12) 6.3 (4) 3.1 (2)
Epithelial-mesenchymal transition in airway and lung remodeling 22.2 (14) 31.7 (20) 33.3 (21) 11.1 (7) 1.6 (1)
Vascular remodeling in pulmonary hypertension, asthma and COPD 31.7 (20) 28.6 (18) 27.0 (17) 11.1 (7) 1.6 (1)
Airway smooth muscle remodeling and dysfunction in asthma and COPD 31.7 (20) 39.7 (25) 14.3 (9) 12.7 (8) 1.6 (1)
Targeting airway remodeling in asthma treatment 29.7 (19) 37.5 (24) 20.3 (13) 10.9 (7) 1.6 (1)
Apoptosis and fibrotic lung disease 20.6 (13) 31.7 (20) 27.0 (17) 19.0 (12) 1.6 (1)
Association between asthma phenotype and airway remodeling 31.3 (20) 25.0 (16) 29.7 (19) 7.8 (5) 6.3 (4)
44
Developing in vivo methods for measuring airway remodeling(Airway Smooth Muscle Airway Remodeling)
45
Epithelial-mesenchymal transition in airway and lung remodeling(Airway Smooth Muscle Airway Remodeling)
46
Vascular remodeling in pulmonary hypertension, asthma and COPD(Airway Smooth Muscle Airway Remodeling)
47
Airway smooth muscle remodeling and dysfunction in asthma and COPD(Airway Smooth Muscle Airway Remodeling)
48
Targeting airway remodeling in asthma treatment(Airway Smooth Muscle Airway Remodeling)
49
Apoptosis and fibrotic lung disease(Airway Smooth Muscle Airway Remodeling)
50
Association between asthma phenotype and airway remodeling(Airway Smooth Muscle Airway Remodeling)
51
Integrating Structure and Function Imaging and Modeling
52
Most Desirable Desirable Somewhat Desirable Not Desirable Least Desirable
Lung imaging integrating lung and cell mechanics 33.3 (21) 44.4 (28) 12.7 (8) 4.8 (3) 4.8 (3)
Mathematical modeling of lung disease 11.1 (7) 27.0 (17) 38.1 (24) 15.9 (10) 7.9 (5)
Imaging novel techniques 20.3 (13) 46.9 (30) 21.9 (14) 7.8 (5) 3.1 (2)
Imaging early detection of disease 35.9 (23) 28.1 (18) 20.3 (13) 14.1 (9) 1.6 (1)
Imaging physiological mechanisms in health and disease 38.1 (24) 33.3 (21) 19.0 (12) 7.9 (5) 1.6 (1)
Ventilation heterogeneity theoretical modeling to imaging 23.4 (15) 23.4 (15) 32.8 (21) 17.2 (11) 3.1 (2)
Nanotechnology in detecting and treating lung disease 25.0 (16) 31.3 (20) 23.4 (15) 14.1 (9) 6.3 (4)
53
Lung imaging integrating lung and cell mechanics(Integrating Structure and Function Imaging and Modeling)
54
Mathematical modeling of lung disease(Integrating Structure and Function Imaging and Modeling)
55
Imaging novel techniques(Integrating Structure and Function Imaging and Modeling)
56
Imaging early detection of disease(Integrating Structure and Function Imaging and Modeling)
57
Imaging physiological mechanisms in health and disease(Integrating Structure and Function Imaging and Modeling)
58
Ventilation heterogeneity theoretical modeling to imaging(Integrating Structure and Function Imaging and Modeling)
59
Nanotechnology in detecting and treating lung disease(Integrating Structure and Function Imaging and Modeling)
60
Respiratory and Peripheral Muscle Biology/Physiology
61
Most Desirable Desirable Somewhat Desirable Not Desirable Least Desirable
Cell and molecular mechanisms for respiratory and peripheral muscle failure 19.4 (12) 32.3 (20) 33.9 (21) 12.9 (8) 1.6 (1)
Respiratory and peripheral muscle dysfunction in sepsis 18.0 (11) 27.9 (17) 19.7 (12) 24.6 (15) 9.8 (6)
Skeletal muscle weakness in COPD 17.5 (11) 34.9 (22) 27.0 (17) 14.3 (9) 6.3 (4)
Respiratory muscle failure in muscular dystrophy 6.5 (4) 38.7 (24) 22.6 (14) 21.0 (13) 11.3 (7)
Acquired weakness syndromes in critical illness 12.7 (8) 34.9 (22) 25.4 (16) 15.9 (10) 11.1 (7)
Mechanical ventilation induced diaphragm dysfunction 11.3 (7) 32.3 (20) 27.4 (17) 22.6 (14) 6.5 (4)
Mechanisms for exercise endurance in asthma and COPD 23.1 (15) 27.7 (18) 27.7 (18) 13.8 (9) 7.7 (5)
Exercise rehabilitation programs for COPD 21.5 (14) 24.6 (16) 29.2 (19) 13.8 (9) 10.8 (7)
62
Cell and molecular mechanisms for respiratory and peripheral muscle failure(Respiratory and Peripheral Muscle Biology/Physiology)
63
Respiratory and peripheral muscle dysfunction in sepsis(Respiratory and Peripheral Muscle Biology/Physiology)
64
Skeletal muscle weakness in COPD(Respiratory and Peripheral Muscle Biology/Physiology)
65
Respiratory muscle failure in muscular dystrophy(Respiratory and Peripheral Muscle Biology/Physiology)
66
Acquired weakness syndromes in critical illness(Respiratory and Peripheral Muscle Biology/Physiology)
67
Mechanical ventilation induced diaphragm dysfunction(Respiratory and Peripheral Muscle Biology/Physiology)
68
Mechanisms for exercise endurance in asthma and COPD(Respiratory and Peripheral Muscle Biology/Physiology)
69
Exercise rehabilitation programs for COPD(Respiratory and Peripheral Muscle Biology/Physiology)
70
Other
71
Most Desirable Desirable Somewhat Desirable Not Desirable Least Desirable
Hypertonic saline inhalation for cystic fibrosis 11.1 (7) 12.7 (8) 46.0 (29) 23.8 (15) 6.3 (4)
Genetics of COPD 21.9 (14) 34.4 (22) 25.0 (16) 10.9 (7) 7.8 (5)
72
Hypertonic saline inhalation for cystic fibrosis(Other)
73
Genetics of COPD(Other)