??????

1
????

• ??? ???
• ???? 95 ? 3 ? 18 ?

2
? ?

• ???????
• ??????
• ???????
• ????????
• ???????
• ???????
• ????????
• ???????
• ????

3

• ?????????????????????????,???????????10???,???????
  ???100?????
• 2003????????????????????,?????????????????????
• ???????????????????????????????????????,??????????
  ??????????DNA?????,?????,?????????????????????????
  ??
• ?????????????????????????????????????????????

4
???????

• 2000??????????DNA?????????????,??DNA??(DNA
  motors)?
• DNA?????DNA??(three single strands of
  DNA)???A(???)?B(??)?C(??)?A???????????B?C?????????
  ???????????B?C????????????,????????????,DNA???????
  ??(molecular switch)?

5

• ??(???)??????????????????,??1?0????????
• ?????????????????,???????(DNA???????????)?????,???
  ?????????????????(molecular computer)?

6

• ??DNA??????(?)????NA??????????????????(?)????????
  ?,???????(self-assrmbling)?????(micro-circuits)?
• ???,??DNA??????????????30?(trillion)(1012)?,?????
  ????????Bell?????????10???????????????

7
??????

• ?????,?????(computer technology)?????(gene
  technology)???,?????????????(computer
  chips)???DNA????(bio-chips)?
• ???????????????,???????????,??????????????????????
  ??????,???????????????????????DNA??,???????????DNA
  ????????????????(nucleotides)???

8

• ????????????????????,??????????DNA????,???????????
  ??????????????????????????(fluorescent
  chemical)????????????DNA??????????????????DNA?????
  ???,??????????????????????????????????????????????
  ??

9

• ?21????,?????????????,????????????????????????????
  ????????,????????????,????,?2005???30????

10
???????

• ??????????????(smart drug delivery
  systems)??????????????????????(body
  cells)?????????????????
• 1. ??(virus)
• 2. ???(lipids)
• 3. ???(polymers)

11

• ????????????
• 1. ??????DNA????(????)???(package)????????????
• 2. ??????DNA?????????(enzymes)??????DNA??????????
• 3. ????????(toxic) ?

12

• ??????????????????????????????
• Mark E. Davis (California Institute of
  Technology)??????????ß-cyclodextrins
  (CDs)????,??DNA??????????(nanometer-size
  particles), Davis?????????????????????(liver
  diseases)????
• ???(lipids)???????????????????

13
????????

• ?????????,?????,??????????????????????????????????
  ???,???????(digestive acid)???????????????????????
  ?????
• ??????
• 1. ?????????(bioadhesive polymers)???????????????(
  mucosa) ?
• 2. ?????(targeting molecule)????,?????????????(rec
  eptors)????
• 3. ?????(carrier molecules)????,?????????

14

• ?????????????
• 1. ????????
• 2. ???????

15
???????

• ??????????????(controlling release)???????????????
  ,??????????????????????????????????(microchips)???
  ?????????????????????????????????????
• ???????????????,????(thin gold foil)??????????????
  ,????????????????

16
???????

• ????????,?????????????????????????????????
• ??,??????(MIT)????????????????????????????????????
  ?????,????????,??????????????????????????

17

• ??????????????????????????,??????????,??????????,?
  ??????30?????????
• ?????????????????,??,?????????????????????????????
  ,??????????SARS??????

18
????????

• ?1997?,??????????,????????????,??????
• ????????????,?????????,?????????????????????,?????
  ?????????????????????

19

• ?????????????????????
• ?????????(Small-molecule Drug and lmmunization)
• ????????(Somatic Cell Gene Therapy)
• ???????(Somatic Cell Gene Repair)
• ?????(Stem Cell Transplants)
• ???????(Germ line genetic Modification)
• ??????(Nuclear Transfer and Cloning)

20

• ???????????,?????????,?????????????????????
• ?????(gene modification)????,????(cotton)???????B
  acillus thuringiensis??,??????????80?
• ??????????2003??????,??????????????

21

• ?????????????????????????????????????????????????,
  ??????????????,????????????,???290???,????????,???
  ???????

22
???????

• ???(spider silk)????????(biomaterials)???????,????
  ?????????????
• ???????????????(dragline silk),?????1/200mm(?????1
  /10),???40 (????8,???20),??400,000psi(???????),
  ???(?????25)????????(biodegradable)?
• ?????????????(polymerized protein)???????(glycin?a
  lamin)?????????????

23

• ??,??????????????????(???ProNectin
  F)???,????????????,??????????????(goat egg
  cell)?????????????????????????????????????????????
  ??Nexia Biotchnologies??????

24

• ?????????(recombinant fibers)???????,???????????
  ???
• ????????????????
• 1. ?????Monsanto??1996??????????????????????????
• 2. ???????????????????20?50?????
• 3. ??????Dupont?Monsanto??????????????????,??????
  ?????

25

• 4. ???????1996???????????,?????????????????????,?
  ???????????????
• 5. ???????????????????????,???????????????
• 6. ???Monsanto???????????????????
• 7. ??????????????????????

26
????

• 1??????????????
• 2??????????????
• 3??????????????