CZ5226: Advanced Bioinformatics Lecture 3: MHC Molecules Prof. Chen Yu Zong Tel: [phone] Email: [e-mail] http://xin.cz3.nus.edu.sg Room 07-24, level 7, SOC1, National University of Singapore

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CZ5226 Advanced BioinformaticsLecture 3 MHC
MoleculesProf. Chen Yu ZongTel
6874-6877Email csccyz_at_nus.edu.sghttp//xin.cz3.
nus.edu.sgRoom 07-24, level 7, SOC1, National
University of Singapore
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MHC in Immune System
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MHC in Immune System
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MHC in Immune System
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MHC in Immune System
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MHC in Immune System
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MHC in Immune System
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T-Cell Recognition of Peptide Antigen through
MHC-peptide complex
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T-Cell Recognition of Allogeneic MHC
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Classes of MHC
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Antigen capture and display
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Antigen capture and display
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Cross Presentation of Antigens
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MHC Genes
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MHC Genes
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MHC Genes
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Properties of MHC genes
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Properties of MHC genes
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Properties of MHC Genes
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Properties of MHC Genes
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Properties of MHC Genes
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Structure of MHC
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MHC Gene and Protein Structure
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MHC protein structure
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MHC protein structure
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Peptide Binding to MHC
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Peptide Binding to MHC
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MHC-peptide structure
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MHC-peptide structure
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Peptide Binding to MHC
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Peptide Binding to MHC
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Peptide Binding to MHC
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Peptide Binding to MHC
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Peptide Binding to MHC
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MHC and Diseases
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MHC and Diseases
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Summary of MHC

• MHC-I consist of an alpha chain and beta-2
  microglobulin and present endogenous peptides to
  T lymphocytes, which are processed by the
  cytosolic pathway in APC.
• MHC-II have alpha and beta chains and present to
  T cells exogenous peptides processed by the
  endocytic pathway.
• Non-classical MHC are involved in antigen
  processing, presentation and tolerance induction.
• Minor H antigens are genetic variants of peptides
  presented by MHC to T cells and cause graft
  rejection and graft versus host reaction.
• HLA has an association with autoimmune disease
  due to its capacity of altering antigen
  presentation and clearance, lympocyte activation
  and tolerance induction.

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Summary of Todays lecture

• Adaptive immune system
• Comparison between innate and adaptive immune
  system
• Relevant cells and related molecules