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• ...?????? ?????, IDDM, ?? ?????? ??????
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??????? ???? ?? ????? ???? ?? ?????? ?????

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• ????? ????? ?????, ????? ????? ??? ??????

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• ????? ??? ???? ??????? ?? ?? ????? ?????? ??
  ?????? ???? ????? ??? ???? ??? ????? ??? ???????
  ????? ???? ??????. ??????? ???? ??????? ?????
  ???? ????????????? ??? ????? ????? ???? ??????
  ???? ?? ??????? ???? ???? ??????? ????? ??
  ??????? ??????.

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• ?????? ?????????????? (??????? ??? ?????? ????
  ???? ???? ?????????? ?????) ?????? ????? ???????
  ??????? ?? ????? ?????? ????? ?? ??? ???????
  ,??????? ????? ??????? ??????? ?? ??????? ???????
  ????? ?? ??? ??????? ?? ????? ?????? ????? ????
  ?? ????, ?? ??? ???? ???? ????? ????? ?? ????
  ??????? ?????? ?? Lactose Intolerance ??????????
  ???.

6
???? ????? ????? ?? Willet Giovannucci ???
?????? ?- Scientific American

• But the highest rates of fructures are found in
  countries with high dairy consumption, and large
  prospective studies have not shown a lower risk
  of fructures among those who eat plenty of dairy
  products.
• W.Willet, L. Giovannucci. Eat, drink and be
  healthy. The Harvard Medical school guide to
  healthy eating. Pub. Simon Schuster, 2001.

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????? ??????

• The Harvard Nurses Health Study, which followed
  more than 75,000 women for 12 years, showed no
  protective effect of increased milk consumption
  on fracture risk. In fact, increased intake of
  calcium from dairy products was associated with a
  higher fracture risk.
• Feskanich D, Willet WC, Stampfer MJ, Colditz GA.
  Milk, dietary calcium, and bone fractures in
  women a 12-year prospective study. Am J Public
  Health 199787992-7.

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• Australian study(2) showed the same results.
  Additionally, other studies (3,4) have also found
  no protective effect of dairy calcium on bone.
• 2. Cumming RG, Klineberg RJ. Case-control study
  of risk factors for hip fractures in the elderly.
  Am J Epidemiol 1994139493-505.3. Huang Z,
  Himes JH, McGovern PG. Nutrition and subsequent
  hip fracture risk among a national cohort of
  white women. Am J Epidemiol 1996144124-34.4.
  Cummings SR, Nevitt MC, Browner WS, et al. Risk
  factors for hip fracture in white women. N Engl J
  Med 1995332767-73.

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• Decrease your risk of osteoporosis by reducing
  sodium and animal protein intake in the diet,
  increasing intake of fruits and vegetables,
  exercising, and ensuring adequate calcium intake
  from plant foods such as leafy green vegetables
  and beans, as well as calcium-fortified products
  such as breakfast cereals and juices.
• Tucker KL, Hannan MR, Chen H, Cupples LA, Wilson
  PWF, Kiel DP. Potassium, magnesium, and fruit and
  vegetable intakes are associated with greater
  bone mineral density in elderly men and women. Am
  J Clin Nutr 199969727-36.

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Dairy Osteoporosis

• ??? ???? ???? ???????? ?? 72,000 ???? (????
  ??????) ????
• Neither milk nor a high-calcium diet appears to
  reduce risk. (for hip fractures. DK).
• Feskanich D, et al. Calcium, vitamin D, milk
  consumption, and hip fractures a prospective
  study among postmenopausal women. Am J of Clin
  Nutr, Vol. 77, No. 2, 504-511, February 2003.

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• ????? ????? ???? ?? ??????? ??????? ?? ???? ???
  ?????? ???? ?????? ???
• Of the few stronger-evidence studies of dairy
  foods and bone health, most had outcomes that
  were not significant.
• Weinsier R, Ksumdieck CL. Dairy foods and bone
  healthExamination of the evidence. Am J Clin
  Nutr 200072681-89.

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• ????? ??? ???? ?? ???? ??? ????? ????? ???
  ??????? ????, ????? ??????? ??? ?????? ??????
  ??????? ??????? ????????? ???????? ????? ???
  ??????? ??? ???? ?? ????? ???????? ?????? ??
  ????? ????????.
• "Conclusion. Scant evidence supports nutrition
  guidelines focused specifically on increasing
  milk or other dairy product intake for promoting
  child and adolescent bone mineralization.
• Lanou AJ, et al. Calcium, Dairy Products, and
  Bone Health in Children and Young Adults A
  Reevaluation of the Evidence . PEDIATRICS Vol.
  115 No. 3 March 2005, pp. 736-743

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• ????? ?????? ?? ?????? ???????? ????? ?????
  ?????? ??? ?????? ?????? ??? ????? ?????.
• Physical activity is the most important
  modifiable factor that determines increased bone
  growth and development in adolescents.
• Frank R. Greer, Bone Health Its More Than
  Calcium Intake. PEDIATRICS Vol. 115 No. 3 March
  2005, pp. 792-794

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????? ????? ?? ??????

• ????? ???? ???? ???? ???????? ???? ? ????? ?????
  ??????? ?????? ??? ????? ????? ??? ????? ??????
  ??????? ??? ????? ??????? ???? ?????? ????? ???.
• Conclusions Dietary pattern is associated with
  BMD. High fruit and vegetable intake appears to
  be protective in men. High candy consumption was
  associated with low BMD in both men and women.
• Tucker KL, et al. Bone mineral density and
  dietary patterns in older adults the Framingham
  Osteoporosis Study.. Am J Clin Nutr, Vol. 76, No.
  1, 245-252, July2002.

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• ?? ??????? ????? ???????? ???? , ??????
  ?????????, ?????? ???? ???? ???? ???? ?????,
  ????? ????? ?? ??? , ?? ??? ????? ???? ???? ????,
  ???? ????? ???????. ?? ??? ?? ???? ????? ??? ,
  ?????? ???? ???? ????? ????? ????? ????? ??
  ?????? ?????????????. ????? ???? ??????? ??????
  ???? ???? ?????? ?? ??? ?????? ???????? ?????
  ????? ?????? ????? ?? ????? ????? .

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Modern Nutrition In Health Disease - ???? ??
?????????????- 1999

• The average protein intake in many
  industrialized countries is at least 50 above
  recommended levels. Excess protein intake has
  been proposed as a reason for the high incidence
  of osteoporosis in such populations despite
  moderate to-high average calcium intakes. The
  proposed mechanism is the calciuric effect of
  protein. Over a wide range of protein intake, an
  average increase in dietary protein of 1 gram
  results in the loss of an additional 1 mg of
  calcium in the urine. The effect of protein is
  rapid and is not balanced by a change in calcium
  absorption.

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????? ?? ?? Textbook ?????? ??????
??????-???? ?? ??????????????

• Another factor implicated in bone loss is the
  possibility that excessive acid intake,
  particularly in the form of high-protein diets,
  results in dissolution of bone in an attempt to
  buffer the extra acid.

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??? ?????- ??? ????? ??????

• ??? ??????? ?????? ????? ???? ??? ?????? ?????.
  ??? ????? ??? ???? ????? ???? ????, ?? ???? ?????
  ???? ????? ????.
• Increased phosphorus has an opposing effect on
  calcium balance A diet high in phosphorus and
  low in calcium produced an increase in PTH
  secretion. If extended over a long period of
  time, it is suspected that this common dietary
  pattern could lead to unfavorable bone balance,
  but this has not been demonstrated.
• Modern Nutrition in Health Disease. Williams
  .Willkins 9th edi. 1998. p. 1359.

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????? ??? ?????

• W.Willet Stampfer MJ. ??????? ?????? ??????
  ??? ??????? ????? ????? ????? ???????? ???????
  ???? ????? ???? ???? ???? ??????? ?????, ?????
  ??????, ????? ????? ???? ??????? ???????? ???????
  ?????? ??? ???????.
• " What is more, we cannot assume that high dairy
  consumption is safe in several studies, men who
  consumed large amounts of dairy products
  experienced an increased risk of prostate
  cancer, and in some studies, women with high
  intakes had elevated rates of ovarian cancer.
• Willet WC, Stampfer MJ. Rebuilding the Food
  Pyramid. Scientific American, January 2003 , pp.
  52-59.

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• According to a study by Daniel Cramer, M.D., and
  his colleagues at Harvard, when dairy product
  consumption exceeds the enzymes capacity to
  break down galactose, it can build up in the
  blood and may affect a womans ovaries.
• Cramer DW, Harlow BL, Willet WC. Galactose
  consumption and metabolism in relation to the
  risk of ovarian cancer. Lancet 1989266-71.

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• Higher intake of meat and dairy products has
  been associated with greater risk of prostate
  cancer, which may be related to their saturated
  fat content.
• Modern Nutrition In health Disease 1999, P.
  1250. Diet, nutrition, and the prevention of
  cancer.

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• In a large case-control study among various
  ethnic groups within the US, consistent
  association with prostate cancer risk were seen
  for saturated fat, but not with other types of
  fat.
• Whitteemore AS et al. J Natl Cancer Inst
  199587652-61.

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• Although further data are desirable, the
  evidence from international correlations,
  case-control, and cohort studies is reasonably
  consistent in supporting an association between
  consumption of fat-containing animal products and
  prostate cancer incidence.
• Modern Nutrition In health Disease 1999, P.
  1249. Diet, nutrition, and the prevention of
  cancer.

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• IGF-I is found in cows milk and has been shown
  to occur in increased levels in the blood by
  individuals consuming dairy products on a regular
  basis.
• A recent study showed that men who had the
  highest levels of IGF-I had more than four times
  the risk of prostate cancer compared with those
  who had the lowest levels.
• Chan JM, Stampfer MJ, Giovannucci E, et al.
  Plasma insulin-like growth factor-1 and prostate
  cancer risk a prospective study. Science
  1998279563-5.

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????? ??? ?????? ??

• ???? ????, ??? ?? ????? ????? ????? ???, ?????
  ???? ???? ??????? ???? ?????? ??????? ??????
  ?????? ????? ??????? ??- Cholesterol-raising
  fatty acids (CRFA) ??? ?????? ??????? ????
  ??????.

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Cholesterol-raising fatty acids (CRFA)

• can be calculated as the sum of
  cholesterol-raising saturated FA plus trans FA.
  About 2/3 of Saturated FA in the american diet
  comes from animal fat. Sources of animal fat
  include milk fat and meat fat. Milk fat is more
  hypercholesterolemic than meat fat because of its
  higher content of cholesterol-raising fatty
  acids.
• Modern Nutrition In health Disease 1999, P.
  1203. In Management of Hyperlipidemia
  Atherosclerosis

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Most prevalent FAs in milk C14/16/180

• A review of the literature shows palmitic acid
  (C160) to be a potent CRFA. Another SFA ,
  Myristic acid (C140), occurs in lesser amounts
  in the diet, but it appears to be even more
  potent than palmitic acid in elevating the serum
  LDL- Cholesterol concentration.
• Modern Nutrition In health Disease 1999, P.
  1203. In Management of Hyperlipidemia
  Atherosclerosis.

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????? ????? ??????? ????

• ?????? ?????? ????????? ????????? ?? ??? ????
  ???? ???????? ???? ???????? ?? ?????? ?????????,
  ?????? ??? ???? ??? ?? ????. ?????? ?? ???????,
  ??????? ??????? ?? ???????? ????? ?????? ?????
  ??? ?"? ??????? ?????????????? Willet WC,
  Stampfer MJ, ????? ?? ????? ???? ???? ???????.

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• "????? ??? ????? ?????? ???????, ?????? ???? ??
  ??????
• ????? ??? ?????? ?? ??????? ?????? ?????? ????
  ???? ?????, ?????, ?????, ??? ????. ??? ???? ??
  ????? ???? ????? ???, ??? ???? ?????? ?????
  ?????? ??????. ????? ?????? ????? ?? ????? ?????
  ???? ????? ??? ???? ?? ??? ????? ????? ??????
  ?????? ?????? ??? ?????? ??? ???????. "
• Willet WC et al. Mediterranean diet pyramid a
  cultural model for healthy eating. Am J Clin Nutr
  199561 suppl 1402s-1406s.

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????????? - ????? ??? ???? (Centanarians) ??????
?????

• ??????????, ??? ?????? ?? ???, ?? ????? ?????
  ?????? ????? ??????? ????? ??, ????
  ?????????????? ???????? ?????, ??? ????? ????
  ????? ????. ?????? ????? ???? ?????? 2 (???
  ??????) ??????? ?????????? ??? ??????? ?????
  ?????? ???. ????"?, ??????? ????? 18 ?????? ?????
  ??????? ??????? ????????????? ??????, ??? ???????
  ?????? 23 ??? ??????.
• The Okinawa way, Bradley Willcox , Craig Willcox
  , Makoto Suzuki. 2001. Penguin Books. P. 71

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• ???? ?????? ?????????????? ?? ???? ?????
  ????????? ????"?. ????? ????? ?? ??? ?????? ???
  ?????? ????"?. ????"? ?????? ?- 50 ???? ?????
  ??????? ????. ???? ??? ???? (?????? ???? ??
  ??????) ?- 70 ??????? ????? ????"? ??? ????? ??
  ??? (70 ??? ???? 95 ???) ???? ??? 10 ???????
  ????? ???? ???? ????? ??? (7 ??? ???? 64). ???
  ??????? ???? ?????? ????? ?????? ???? ???????
  ???? ??????, ?? ???? ????? ?????? ????.
• Campbell T. C., Junshi Chen. Diet and Chronic
  Degenerative Diseases. in Western Diseases, their
  dieatry prevention revesibility. Edited by Dr.
  Dennis Burkitt. Pp 80-87.

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???? ??????

• ????? ?????? , ????? ????? ???? ???? ???? ??????
  ??????? ?????? ????. ?? ???? ?????? ????? ?????
  ???????? ??????, ??????? ??????? ?????? ????
  ?????. ??????? ?? ????? ????? ????? ???? ?????,
  ????? ???? ???????? ???? ?????? ???????.
  ????????? ??, ????? ????? ?? ????? ??????? ??????
  ????? ?????? ????? ?? ??????.
• Solomon L. Bone density in ageing caucasian and
  African populations. Lancet 1979!!1326-1330.
• Walker A, Labadarios D, Glatthaar I. Diet-related
  disease patterns in south african interethnic
  populations. in Western Diseases, their dieatry
  prevention revesibility. Edited by Dr. Dennis
  Burkitt. Pp 32, 59.

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??????? / ?? ?????? ?????

• ??? ??????? ????? ?? ????? ????? ???? ?????????
  ??????? ????? ?????. ?? ????? ?????? ?? ??????
  ????? ??? ??????? ?????? ???????? ?????
• ????? ??????- IBD, IBS, ????, ??????? ???????
• ???- AD
• ?????- RA
• ????? ??????- AOM, REC. SINUSITIS, ASTHMA
• ???????
• ????? ????-????????

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?????? ??????

• Iacono G, Cavataio F, Montalto G, et al.
  Intolerance of cows milk and chronic
  constipation in children. N Engl J Med
  1998339(16)1100-4.

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COW'S MILK PROTEIN ANTIBODIES,RISK OF IDDM

• A study from Finland shows that drinking cow's
  milk is associated with getting juvenile diabetes
  and the earlier children start to drink milk and
  the more they drink, they more likely they are to
  develop diabetes. (SM Virtanen et al
  .Diabetologia 1994(April)37(4)381-387)

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• According to a report in the October issue of
  Diabetes, exposure early in life to cow's milk
  may increase the lifetime risk of developing
  diabetes in high-risk children
• Diabetes 2000491657-1665.

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?????? ????? ????? ?????? ????????

• Infants weaned before 12 months of age should
  not receive cows milk but should receive
  iron-fortified infant formula.
• From Policy statement by the American Academy of
  Pediatrics (AAP)- Breastfeeding and the Use of
  Human Milk.

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• iron deficiency is more likely on a dairy-rich
  diet.
• Cows milk products are very low in iron. If they
  become a major part of ones diet, iron
  deficiency is more likely.10
• Pennington JAT. Bowes and Churches Food Values of
  Portions Commonly Used, 17th ed. New York
  Lippincott, 1998.

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• Milk, yogurt, and ice cream, despite having
  relatively low glycemic load, are highly
  insulinotropic, with insulin indexes comparable
  with white bread.
• Ostman EM, et al.Inconsistency between glycemic
  and insulinemic responses to regular and
  fermented milk products. Am J Clin Nutr
  20017496-100.

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• ?????? ???? ?????? ???? ????? ???? ??????? ??
  ????? ?????????. ??? ?????? ????????? ????? ??
  ???? ???????? ???? ??? ????? ????? ?????? ??????.
  ???????? ??? ?????? ???? ????? ????? ??????
  ?????? ?????? ???? ?????- ?? ?? ??????, ??? ??
  ?????? ??????? ??????? ???????, ??? ???? ????? ??
  ????? ?????. ???? ???? ????? ?????? ?? ??????
  ??????? ??? ?????? ????? ?????? ??? ?? ????????,
  ???? ???? ?? ??? ??? ????. ???? ?? ??? ??????
  ??????? ?????????? ???? ?????? ?????? ???. ??????
  ??????? ?????? ???? ?? ?? ????? ???. ?? ??????
  ???? ?????? ??????? ????? ????????."
• Prpf. J. Brend-Miller, Prof. Stephen Colagiuri.
• The New Glucose Revolusion. Hodder Headline
  Australia 2002. P. 56.

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????????? ???????????

• ?? ???? 10,000 ??? ?? ??? ???? ?????? ??????/??
  ??? ??? ?? ??? ???? ????? ????? ?????, ??? ???
  ??????? ????.
• ?? ??????? , ??? ????, ?????? ?? ??? ???? ?? ???
  ?????? ??? ???? ????? ???? ?????? ???? ??? ????
  ???? (?????? ?? ??? ?? ??? ????).
• ??? ?? ?????? ????? ????, ???? ??????.

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Dairy consumption on an evolutionary scale

• early direct chemical evidence for dairying
  dates to 6100 to 5500 before present..
• Dairy foods, on an evolutionary time scale, are
  relative newcomers to the hominin diet.
• Loren Cordain, S Boyd Eaton, et al. Origins and
  evolution of the Western diet health
  implications for the 21st century. Am J Clin Nutr
  Vol 81, No 2, 341-354, Feb 2005.