????

1

2014.9.9
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• ?? ?

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2
???????
????? RBE or RBEM
?????????, DT (Gy)
???????, WR
??????????
????? (?????????? ?????QOL??)
????, HT (Sv)
??????, WT
?????
????, E (Sv)
3
RBE
?????????????????
A normal cell contains 46 chromosomes. Each
chromosome carries one centormere.
normal (1 centromere)
Dicentrics Rings
Fragment
Centromerejoint point
??Hayata et al., J. Radiat Res., 2001
4
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??????????
??????????(1-???)
QOL?????
????????????????? ???????? ????????
????????????????????
???????
?????????(???????)
?????????
(???1????)
??????
5
?????????????
??? F(E,O)????? K ???(Gy) D ????(Gy)
?????????????? Reference phantom
Q(L), ICRU? ????????
??
??
?
??? H(d) ??????(Sv) H(d,O)???????(Sv) Hp(d)
??????(Sv)
??? E ????(Sv) HT ????(Sv) DT ??????(Gy)
??
(??)
??
??
??? ??????(?)(Gy/h)
???????? ??????? ?????
?????????????(?????????????QOL?)
?????????
6
(No Transcript)
7
?????????????

• ????100mSv????????????????????????????????????????
  
• ICRP??????????????????????????????????????????????
  ????(LNT??)????????????

8
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???
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(1cm????)
??????? (?????????)
H(10)
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(70µm????)
(ex ??)
H(0.07,0)
????????
?????
??????
????
(1cm????)
Hp(10)
?????????? (????????)
??????
????
(70µm????)
(ex ??)
Hp(0.07)
(?????)
??????????
?????????
lt
?????????????????
9
????????????????
??? (Protection quantity) ????? ?????(ICRP) ???? (Sv) ????(Sv) ??????(Gy)
??? (Operational quantity) ????? ???????(ICRU) ??????(Sv) ???????(Sv) ?????? (Sv)
10
????????????
11
??????????????(??)??
????(????????) / ??????
134Cs605keV 796keV
137Cs662keV
?????????(MeV)
(?????? ?????(???????)????? 2011.10.23)
12
??????????????(???0??)??
???? / ??????
134Cs605keV 796keV
137Cs 662keV
?????????(MeV)
(?????? ?????(???????)????? 2011.10.23)
13
??????????
??? ???? ?????????
?????????????? Reference phantom
?????ICRU?
??
??
?
??? ??????(Sv) ???????(Sv) ??????(Sv)
??? ????(Sv) ????(Sv) ??????(Gy)
??
??
(??)
???????? ??????? ?????
?????????????(?????????????QOL?)
14
???????????????
????? RBE or RBEM
?????????, D
???????, WR
??????????
????? (?????????? ?????QOL??)
????, HT
??????, WT
?????
????, E