Immune Risk Phenotype

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Immune Risk Phenotype

• Dr. Gabriele Rumi

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Effect of the genetic background and aging on the
immune system
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Interplay between the IRP, low grade
inflammation, and cognitive impairment in
mortality
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Circulating cytotoxic CD8() CD28(-) T cells in
ankylosing spondylitis.
From the clinical perspective, the percentage of the cytotoxic CD8 CD28 T cells reflected a more severe course of disease, as it correlated with distinct movement restrictions, as well as the metrology score summarizing cervical rotation (in sitting position), chin-to-jugulum distance, thoracic Schober, chest expansion, and fingers-to-floor distance (P 0.032).Schirmer M, Goldberger C, Würzner R, Duftner C, Pfeiffer KP, Clausen J,Neumayr G, Falkenbach A. Arthritis Res. 20024(1)71-6. Epub 2001 Oct 16. PubMed
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Immunological biomarkers of ageing in man changes
in both innate and adaptive immunity are
associated with health and longevity