????? ??????? The Autism Explosion

1
????? ??????????? ?????? 3 ?????? ?????? ??
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?????????? ?? ???? 15 ???? 2005 ??? ?? ???

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2
????? ??????? The Autism Explosion
2003 1133
1994 11000
3
????? ??????? The Autism Explosion
4
????? ??????? The Autism Explosion
????? ?? 700 ?10 ????
5
????? ???????- ????? ????? ???????
???? ????"? 1980-2002
????? ?? 100 ?10 ????
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????? ???????- ????? ????? ???????
????? ??? ????"? 1960-2002
????? ?? 100 ???????? ????? ???? ?70
????? ?? 400 ?????? ????? ???? ?70
7
?????? ???? ???? ???? ??????? ?????? ??????
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• ?? ?? ??????
• ????- ????, ????, CO2 , ??? ???, ???? ????? ?????
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• ????? ???? ??????- ????? ???? ??? ??????

8
?????? ?????? ?????? ??????? ????? ????????

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• ?????? ???? ????? Leaky Gut Syndrome ?????
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9
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• ?????? ?????? ??? ?? ???? 50 ???
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  ????? ???? ??????.

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?????? ???? ????? ?? ?? ???????, ?? ??? ??????,
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10
??????? ????? ???? ??????? ???????? 1992
"???? ??"

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???? ??? ????? 6
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???????- ???? ??????? (?)
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??? 2
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0
37.5
75
112.5
150
0
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????
16
The vicious cycle
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"??".
19
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26
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30
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  ???? ????? ?????? ???????? Molecular Distillation
  ??? ?????? ???????? ???? ????? (??? ??? ???
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31
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• ??? ???? Safflower
• ??? ???????? (?????...)
• ???? ????? ?????? Trans Fatty ??????? ???????
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32
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• ??????

33
?????? ???? ??????- ???? ?????????

?????? ???? ??????? PUFA
????? ????? 6
????? ????? 3

????? ???????? LNA ????? ???? ????, ???, ?????,
????,?????, ???? ????, ????? ??? ??????, ???
?????? ????
????? ???????? LA ?????, ??????, ????? ??????,
??? ?????? ??????

Enzymes



Delta 6

Desaturase
D6D

D6D D5D

Elongase

????? ????????????? Eicosapentanoic Acid
EPA ???????, ???? ??? ??, ??? ??? ??
????? ??? ???????? GLA ??? ????' ???, ?? ?????,
Rape seed oil
Delta 5

Desaturase


Enzymes

Lipoxygenase
(LOX)

Elongase

Elongase

Cycloxygenase
????? ?? ???? ??? ???????? DGLA
????? ????????????? Docosahexaenoic Acid
DHA ???? ??? ??, ??? ??? ?? ???? ?? (??? ???)
(COX)



D5D

COX LOX

COX

????? ????????? AA ???????????? 6 ?
???????????? ?????? ?3
????????? A3 ???? ????? ?? ????
??????????? PGE1 ???? ???? ????


????????? A2 ???? ????? ?? ???????

????????? LTB5 ???? ????? ????
????????? LTB4 ???? ????? ???????

??????????? PGE3 ???? ???? ????
??????????? PGE2 ???? ???? ???????
34
"???????? ???" HDL
"???????? ??" LDL