Curcumin%20Extreme

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Curcumin Extreme

• Julian Blumenfeld, MD
• Chief Medical Officer
• Market America nutraMetrix

Curcumin Extreme Code 13145 and 13145NM
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Curcumin Extreme

• Curcumin (BCM-95) 400 mg
• Broccoli Seed Extract (6 Glucosinolates) 167 mg
• Selenium (Selenomethionine) 100 mcg

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Curcumin

• Turmeric root extract
• 3 major curcuminoids
• Curcumin
• Demethoxycurcumin
• Bis-demethoxycurcumin

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Curcumin Biological Activities

• Powerful antioxidant
• Promotes normal activity of NF-kappaB
• Promotes normal cell cycle activity, normal
  cellular regeneration
• Promotes neurological health, helps to maintain
  neurological health as we age

• Reduces superoxide anions
• Reduces peroxides
• Inhibits LDL oxidation and lipid peroxidation

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Curcumin Biological Activities

• Powerful antioxidant
• Promotes normal activity of NF-kappaB
• Promotes normal cell cycle activity, normal
  cellular regeneration
• Promotes neurological health, helps to maintain
  neurological health as we age

In unhealthy cells, curcumin has been shown to
interfere with multiple cell signaling pathways,
including cell cycle (cyclin D1 and cyclin E) and
apoptosis.
-Anand, P., et al. Curcumin and cancer an
old-age disease with an age-old solution.
Cancer Letters. 267 133-164, 2008.
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Curcumin Biological Activities
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Curcumin Biological Activities

• Powerful antioxidant
• Promotes normal activity of NF-kappaB
• Promotes normal cell cycle activity, normal
  cellular regeneration
• Promotes neurological health, helps to maintain
  neurological health as we age

Curcumin can cross the blood-brain barrier and
bind directly to amyloid plaques and increase the
uptake of amyloid-ß protein by macrophages.
-Zhang, L., et al. Curcuminoids enhance
amyloid-beta uptake by macrophages of Alzheimers
disease patients. Journal of Alzheimers Disease.
10 1-7, 2006.
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Curcumin The BCM-95 Difference
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Broccoli Seed Extract (6 Glucosinolates)

• Promotes the normal production of detoxification
  enzymes
• Helps maintain healthy glutathione levels
• Promotes apoptosis in unhealthy cells
• Promotes a strong immune system

Cytosol
H S
H S
Nucleus
keap1m
keap1c
nrf2
keap1m
keap1c
ARE
S H
S H
GSTs, GR, GPx, HO-1
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Broccoli Seed Extract (6 Glucosinolates)

• Promotes the normal production of detoxification
  enzymes
• Helps maintain healthy glutathione levels
• Promotes apoptosis in unhealthy cells
• Promotes a strong immune system
• Enhance total white blood cell count
• Enhance phagocytic activity
• Reduced elevated TNFa from LPS stimulated
  macrophages

-Thejass, P. and Kuttan, G. Immunomodulatory
activity of sulforaphane, a naturally occuring
isothiocyanate from broccoli (Brassica oleracea).
Phytomedicine. 14 538-545, 2006.
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Selenium (Selenomethionine)

• Required cofactor for selenoproteins
• Glutathione peroxidase enzymes
• Iodothyronine deiodinase enzymes

Glutathione
H
H
O
O
H
H
Glutathione
H
H
Thyroxine (T4)
Thyroid Hormone (T3)
-Brown, K. and Arthur, J. Selenium,
selenoproteins and human health a review. Public
Health Nutrition. 4 593-599, 2001.
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Curcumin Extreme

• Directions Take one capsule per day, with or
  without a meal.
• Warning If you are currently taking warfarin
  (Coumadin) or other anti-platelet/anti-coagulant
  medications, you should not take this product.
  If you are taking any other prescription drugs or
  have an ongoing medical condition, you should
  consult your physician before using this product.
  Women who are pregnant or nursing should not
  take this product.

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Summary

• Curcumin Extreme
• Curcumin (BCM-95) 400 mg
• Broccoli Seed Extract (6 Glucosinolates) 167 mg
• Selenium (Selenomethionine) 100 mcg
• Why curcumin? Why now?
• Who would benefit?

Curcumin Extreme Code 13145 and 13145NM DC
28.50 SR 39.95 BV 23
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