Grant Writing

1
Grant Writing ApproachWhat if you dont get
anticipated results?LimitationsTimeline

• Emelia J. Benjamin, MD, ScM
• The NHLBIs Framingham Heart Study
• Boston University School of Medicine

• No industry relationships to disclose
• 2R01HL092577
• 1P50 HL120163
• N01-HC 25195

2
ApproachOrder Elements

• Rationale
• Hypothesis
• Preliminary results
• Methods
• Sample
• Design
• Statistical analysis
• Power
• Anticipated results
• Possible problems and potential solutions
• Read grant from paragraph headings

3
ApproachExpected Outcomes

• Outline for each aim
• Purpose
• Synthesizes each of the aims outcomes
• Reinforces how aim advances field ROI
• Provides reviewer reassurance that you have back
  up plan if outcome not met

4
ApproachPotential Problems Alternative Strategies

• Purpose
• Demonstrates awareness of limitations
• Resilience
• Types of problems

• Generalizability
• Multiple testing
• Misclassification
• Confounding
• Over-adjusting
• Changing technology

• Temporality
• Bias
• Causality
• Specific assay
• Correct model
• Enrollment problems

5
ApproachTimeline

• Purpose
• Gives reviewers perspective/flow of work
• Pitfalls
• Illogical sequence
• Not grounded in Specific Aims
• Over-ambitious
• Under-ambitious
• Absent timeline