Antihypertensive drugs

1
?21?
????? Antihypertensive drugs
???? ??? Tel [phone]
2
??????????? (WHO,1999)
? ? ??? (SBP) ??? (DBP) ?????
(mmHg)
(mmHg) ??
1 ???? 140159 9099
??????
(??)
2 ???? 160179 100109 ??????


(??)
???????
3 ???? ?180 ?110
???????
(??)
????
?????????(?????,1999?10?)
3
????????????
????????-?????-?????
?????????????
4
?? ???
???? hydrochlorothiazide
5
??? (????, hydrochlorothiazide )
?????? 1. ?????? 2. ??????,??, 3 .???????????
1)???????---??????,????-- ????--???
2)??? 3)???,??? 4)??????
6
?.??????????????
(?)??????????? ( angiotensin
converting enzyme inhibitors, ACEI)
???? captopril (?????,???)
7
???? captopril
3. ???????????????A2?????? ????
PGE2,PGF2????????? 4. ??????NO??? 5.
????????????????? 6. ????????????????,????
??????,?????????? 7. ??????????TG?TC,??HDL
8

• ???? captopril
• ????
• 1 . ?????
• 2 . ???????
• ??????
• ???
• ??
• ???
• ??????
• ??,????,???,????,
• ???????,??????????

9
(?) ???????????
AT1?? ?????,??,?,???????????
??????????????????? AT2?? ?????,????????????
?????????
10

• 1. ???
• ?????AT1?????Ang???????????????????????????
• ??????

?????? 1???? ????1)?????,?????
24h????,36???????
11
??? losartan ?????? 1???? 2)?????ACEI?
. ?????????????? . ????????????????????
2??????????????? 3??????????? 4??????? ???
12
???????
(?)??????? ??? Hydralazine (????) ????????
(?A) 1. ???, ????-????? 2. ?????
1)????????? ???????? ????????????? ?????
?????????????? 2)?????3)??????
4)????(?200mg/?)??????????
13
??? sidium nitroprusside ???A(????)?????-???,????
? ??V(????)-????????,?????
????????????? (NO??) -??????????-??NO-???????????
??? ?cGMP??????-???
?????? 1. ???,????? 2. ?????,?????
14
??? sidium nitroprusside ???? 1.????? 2.????????

• ??????
• ????
• ?????????????,???
• ?????

15
?????? 1???????,??? 2?????,???????? 3????????????
???????
16
???? Amlodipine (???, ????????)

• ??????
• ???????????
• 2. ?????????????(gt 90)
• ????,????,?????
• 3. ???????????????????? ?????????????????
• 4. ?????????????????

17
(?)?????? potassium channel
openers ???????A

1. ??ATP???K??K??????????????Ca2???Ca2???--???
   ?--BP ?
2. Na-Ca2???????Ca2??????????Ca2?????--BP ?
3. ???????IP3????????Ca2????

18
???? minoxidil (???) ?????? 1.
?????,???,????????? 2. ????????????
(????????????) 3. ????(??,10mg/?) ????? 4.
??????????????
19
??? diazoxide ?????? 1. ?????????????? 2.
???????????? 3. ?????????????,??? 4. ????????
20
???????????
?????? ???? Propranolol
???????? 1. ??????,?????? 2. ????????? 3.
????????????
21
???? Propranolol
????????

1. ?? ?????1?????--?????II???
2. ?? ?1??? -?????
3. ?? ????-?????????-?????????-?????
4. ?????????????? ?2??? -?????

22

• ???? Propranolol
• ????
• 1.?????????-(????????)
• 2.????,???????????????,
• ???????????
• ????,?????,??,??,??
• ?????????,??,??,???
• ??(40-60mg/?)??,??????
• ????????????

23
?1????? ??? Prazosin

• ??????
• ??????????1??
• ????????
• ???????

24
?1,?????? ???? Labetalol
?????? 1.???1,?1,?2?? ??2??-????????
2. ??????, ?????, ??????? 3. ???????????
25
????????? (?)????????
??? Clonidine (???????)
26

• ??? Clonidine
• ??????
• 1. ??????
• ???,??????,????????
• ?????????????????
• ????????,??????
• 2. ????

27
??? Clonidine ???????? ????
1. ????????????????(???) ? ???????2?????????????
???? 2. ?????????????????????? ???????
28
??? Clonidine ????1. ??????? 2.
????????? 3. ??????????? ????????? 1.??
???????? 2.????????????? 3.?????(????)????????-
-????
29
?-????(?-methyldopa) ????????
1. ???????????????? 2. ???????????????

3. ??????????
30
?-????(?-methyldopa) ?????? 1 .
???????????????? 2. ??(gt6??)???(1.0/?) ????????
3.?????? ?????? ?????????, ????????,???.
31
???? Moxonidine (?????????) ?????????
???????????1-????? --??????????
1. ??????,??? 2. ???????,??????? 3. ?????? 4.
??????????
32
(?)??????? ??? Mecamylamine ????????? 1.
????????? 2. ????????? 1). ?????? 2).
?????????? 3). ???????????? 3.
?????????????????????????????????????
33
(?) ?????????????
??? Reserpine ????????? 1.???? ??????,??,??
2. ??????????????
34
??? Reserpine ?????? 1. ???????(????0?) 2.
?????? ?????? 1.????????? 2.??????? 3.??????,?
?,??????
35
??? guanethidine (?????) ??????
1.????????,?????? 2.??????? 3.?????????????
4.?????????? ?????? ??NA??????????? ?????,????
? ?????????,??????????????
36
??????????
1. ?????? 2. ??????? 3. ??????????? 4. ?????