HUMAN CARCINOGENESIS :BREAST CANCER MODEL

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DRUGS AFFECTING AUTONOMIC NERVE TERMINALS
??.??. ????? ????????????? Noppamars
Wongwitdecha, Ph.D. Associate Professor Center of
Neuro-Psychopharmacology School of Medicine,
Walailak University
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Objectives

• List the major neurotransmitters of the autonomic
• nerve terminals
• 2. Describe the localization, synthesis,
  storage, release and removal of 1 with diagram
• 3. Explain the steps of enzymatic synthesis and
  inactivation of 1
• 4. Discuss the physiological functions and
  pharmacological actions of 1
• 5. Name the drugs and indicate the sites of drug
  actions on the cholinergic adrenergic nerve
  terminals
• 6. Discuss the pharmacological actions, clinical
  uses and major adverse effects of 5

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Outline
1. The major neurotransmitters of the autonomic
nerve terminals Acetylcholine (ACh),
norepinephrine (NE) 2. Localization, synthesis,
storage, release and removal of 1 with diagram
3. The steps of enzymatic synthesis and
inactivation of ACh, NE, epinephrine, dopamine
4. Physiological functions and pharmacological
actions of ACh, NE, epinephrine, dopamine 5.
Drugs and the sites of drug actions on the
cholinergic adrenergic nerve terminals 6.
Pharmacological actions, clinical uses and major
adverse effects of 5
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Neurotransmitters

1. Acetylcholine (ACh)
2. Norepinephrine (NE)
3. Epinephrine (E)
4. Dopamine (DA)

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Introduction
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Chemical Structure
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Chemical Properties
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Pathways in the PNS (with diagram)
Localization
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Synthesis, storage, release, removal (with
diagram)
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Steps of enzyme synthesis inactivation
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Physiological functions
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Pharmacological Actions
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Tissue organ system effects
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Receptor subtypes

• Classification
• Localization
• - PNS
• Physiological Functions
• Agonists
• Antagonists

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• Drugs affecting ANS nerve terminals
• SNS Drugs Amphetamine, cocain, reserpine,
  bretylium, guanethidine, tyramine, methylrosine,
• PSNS Drugs Hemicholinium, vesamicol, botulinum
  toxin, edrophonium, physostigmine, neostigmine

1. Chemical property2. Pharmacological
actions -Mechanism site of action
(with diagram)3. Clinical uses4.
Adverse effects
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References
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??????

• ???? ?????? ?????????????
• ????
• ????
• ???????????????? ???????????????? ACh, NE, E, DA
• ????????????? ??????? ????????
  ??????????????????? (??????
• nerve terminals ??? ACh, NE, DA ??? Adrenal
  medulla)
• ??????????????? ?????????????????????
• ?????????????????????????
• ????????????????????????
• SNS Drugs Amphetamine, cocain, reserpine,
  bretylium, guanethidine, tyramine, methylrosine,
• PSNS Drugs Hemicholinium, vesamicol, botulinum
  toxin, edrophonium, physostigmine, neostigmine
• - ????????????????????????? (?????? nerve
  terminals)
• - ????????????????????????
• ????
• ??????????