A meta-analyzed estimate of an effect is: - PowerPoint PPT Presentation

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A meta-analyzed estimate of an effect is:

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Title: Introduction to meta-analysis Author: Will Hopkins Last modified by: Reviewer Created Date: 10/24/2000 7:26:03 PM Document presentation format – PowerPoint PPT presentation

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Title: A meta-analyzed estimate of an effect is:


1
  • A meta-analyzed estimate of an effect is
  • an average of qualifying study-estimates of the
    effect
  • getting the same best units or metric for the
    estimates
  • with an inference about its true (large
    study-sample) value
  • showing confidence limits and interpreting their
    magnitude
  • derived using more weight for study-estimates
    with better precision
  • weighting factor is 1/(error variance), when you
    can extract it
  • with adjustment for/estimation of effects of
    study characteristics
  • effects of design, measurement protocol, mean
    type of subject
  • taking into account any clustering of
    study-estimates
  • several treatment doses or assay times on same
    subjects
  • and taking into account residual differences in
    study-estimates
  • the random-effect meta-analysis.
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