Vancomycin - PowerPoint PPT Presentation

1 / 14
About This Presentation
Title:

Vancomycin

Description:

Vancomycin Glycopeptide antibiotic Cynthia Tallent Introduction Glycopeptide antibiotic Used to treat gram-positive bacteria Inhibits bacterial cell wall production ... – PowerPoint PPT presentation

Number of Views:471
Avg rating:3.0/5.0
Slides: 15
Provided by: Patr6168
Category:

less

Transcript and Presenter's Notes

Title: Vancomycin


1
Vancomycin
  • Glycopeptide antibiotic
  • Cynthia Tallent

2
Introduction
  • Glycopeptide antibiotic
  • Used to treat gram-positive bacteria
  • Inhibits bacterial cell wall production
  • Resistant strains have been identified

3
Outline
  • History
  • Properties
  • Inhibition of Cell Wall Biosynthesis
  • Resistance
  • Analog Research
  • Review

4
History
  • Discovered in 1956
  • Originally from Indonesian soil cultures
  • Structure was elucidated in 1983

5
Structure
6
Properties
  • Administered Intravenously
  • Administered Orally
  • pH 3-5 in aqueous solution
  • P 2.5

7
Bacterial Cell Walls
  • Composed of peptidoglycans
  • Help to prevent lysis
  • Gram positive bacteria have thick cell walls

8
Cell Wall Biosynthesis
9
Inhibition of Cell Wall Biosynthesis
10
(No Transcript)
11
Vancomycin Resistance
  • Enterococcus and Staphylococcus aureus
  • Changes D-Ala-D-Ala to D-Ala-D-Lactate
  • Bifunctional model
  • Add Hydrophobic substituents to vancosamine sugar

12
Christopher Walsh
  • Adding Hydrophobic substituents to vancosamine
    sugar
  • Loss of affinity did not lose anti-bacterial
    effect
  • Disaccharide fragments are effective

13
Analogs
  • DCB-PV is effective against Vancomycin Resistant
    Strains

14
Review
Write a Comment
User Comments (0)
About PowerShow.com