Medical Immunology

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?????
Medical Immunology
???
??????? ??????
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??? ???? (cytokine,CK)

• ??? ?????????
• ??? ???????
• ??? ?????????
• ??? ??????
• ??? ???????

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??????
???? ????(cytokine,CK)?????????????????
?(??????????),??????????????????????????????
CK???????,????????????????,????,??????????????????


???? ???????????? ??????????
?????????????????????
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??? ?????????
1. ?????(830kD)??
2. ????????????????, 10-12mol/L
3. ?????????????????????
4. ??????????????????
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??? ?????????
5. ?????????????????

• ??? ??CK???????????
• ????????????
• ??? ??????????????
• ??????????????
• ??? ??CK????CK???
• ??? ??CK????CK???

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??? ?????????
6.?????????

• ????????
• IL-1??IL-2,IL-2??TNF?
• ???????????????
• IL-1???IL-2?????
• ???????????????
• ???????

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??? ???????
???????,?????6?
????? interleukin,IL
??? interferon,IFN
?????? tumor necrosis factor,TNF
?????? colony- stimulating factor,CSF
???? chemokine
???? growth factor,GF
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??? ???????
??????? (interleukin,IL)
????????????????????CK,???????????????,??????
??????CK ?
??????? IL-1
TH1?? IL-2 TH2?? IL-4?5?6
????IL?IL1 ------- IL-35?
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??? ???????
??????? (interleukin,IL)
? ? ???? ? ?
????????(LAF) IL-1 ??????,?????????????? T?B???????,??????,??????
T?????? IL-2 ???T?? T?B????,??NK??,????????
???????(multi-CSF)IL-3 ???T?? ?????????,?????,??,???????????
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??? ???????
??????? (interferon, IFN)
------??????????????????????????????????
?? ?? ?????? ??
IFN-a ????? ???????? ?,????,? ?-???? ???,????,??MHC ??????????
IFN-ß ????? ????? ???,???,????,??MHC?????????
IFN-? ????? ??T??? NK?? ??????,???,??MHC?????????,??Th2????,??Th1????
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??? ???????
????????(tumor necrosis factor,TNF)
?????????,???TNF-a? TNF-ß (?)TNF-a
?????????????(??)
T???NK????????
(?)TNF-ß ??????(lymphotoxin,LT)?TNF-a???????
28???,????????? ???????T???
TNF??????????????????????????
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??? ???????
???????? (colony- stimulating
factor,CSF) 1. ?????????????????????????????????
?????????? 2. ??SCF?GM-CSF?G-CSF?
M-CSF?EPO?TPO?IL-3(multi-CSF)??
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??? ???????
??????(chemokines) (?)??????????????,????????????
???? (?)????????????????
1.CC???MCP-1,??????T???DC?????
???? 2.CXC???IL-8,?????????,??????? 3.C??
? Lymphotactin,?T???NK???DC???
???? 4.CX3C???Fanctalkine,??????T??????
???
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??? ???????
??????(chemokines)
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??? ???????
????????
(?)?? 1. TGF-ß(transforming growth
factor-ß,
??????-ß) 2. EGF(epithelial growth
factor,
??????) 3. FGF(fibroblast growth
factor,
?????????) 4. NGF(nerve growth factor,

??????) 5. PDGF(platelet-derived growth
factor,
?????????) 6. VEGF(vascular endothelial
cell growth factor,
??????????)??
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??? ???????
????????
(?)TGF-?(TGF-?1? TGF-?2?TGF-?3)
1.????T?B?????????????? 2.?????(???????)
(1)??T??????????? (2)??B?????T?????????????
(3)??NK?????IL-2?LAK?????? (4)??Mf????????????
(5)????????(????????????????),?????????,??????
(6)????????TGF-?,????????
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??? ??????????
??????????
????????????DC,??-????,?????,NK??,NKT??,?dT??
,B-1??,??????????????,???????????????????
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??? ??????????
???????????
??????B???aßT?????????????????
1??????? IL-2?15?T????
IL-12?T?Th1??? IFN-???M-Mf?CTL?
IL-2??CTL??????
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??? ??????????
???????????
2??????? IL-4?6?13??B??
IL-4??Th2??? ??Ig????IL-4?IgE
TGF-ß?IgA 3???????
TGF-???CTL?Mf IL-10??Mf
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??? ??????????
??????
1.???????????????????IL-3,SCF?
2.????????????????????
GM-CSF,G-CSF,M-CSF?
3.????????????????IL-7?
4.????????????EPO,TPO,IL-11,IL-15?
??????,??????? IL-2?????T??????
TNF?????????
?????????
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??? ??????
????????????????????????
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??? ??????
(?)???????? ??????????5?
1.????????(IgSF) (1) ??????????????????? (2)
????IL-1?IL-6?M-CSF?SCF????
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??? ??????
2.??????????(????????) (1)???????????????????
??????(C),??????
Trp-Ser-X-Trp-Ser(WSXWS,X??
?????)????? (2)???? IL-2?IL-3?IL-4?IL-5? IL-6
?IL-7?IL-9? IL-11?IL-13?IL-15?GM-CSF?G-CSF????
?
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??? ??????
3.??????????(???????) (1)????????????????????
??????? (2)????I ??II?IFN??? ?
4.?????????? (1)????????????????
(2)????TNF???NGF???Fas??? CD40???
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??? ??????
5.????????(G????????) (1)??????7??????? (
?-??? ?),????G??(??GTP???)??,?
?????????? (2)???? CXCR ---
??CXC?????(?IL- 8) CCR ----
??CC?????(?MCP-1)?
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??? ??????
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??? ??????
(?)???CKR?CKR??? 1.???CKR (1)??????????? (2)??
?? A.????????????,?????????? B.???????,
?????????,?????? ?????,?????????
2.CKR???(????) ?????????????????????????????IL-1
?????(IL-1Ra)??IL-1R???IL-1?????????TNF?IL-1?????
????TNF?IL-1???????
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??? ???????

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??? ???????

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??? ???????
5.??????(cytokine storm) ?????????????????????
???TNF-a?IL-1?IL-6?IL-12? IFN-a?IFN-ß?IFN-??MCP-1?
IL-8??????????? ???????????????????(ARDS)??????
??????

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??? ???????
(?)????????????

• ?????????????,???????????(biological response
  modifier,BRM),?????????
• ???????????????????EPO, IFN, G-CSF, GM-CSF,
  IL-2, IL-11??

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????

• 1. ??????????????
• ??????????????,???????
• ?????
• ??????????????,???????
• ???

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Thank You!