Cephalosporins

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Cephalosporins

• Treatment of a wide range of bacteria including
  those sensitive to penicillin.
• 4 Groupings
• First Generation to Fourth Generation
• Increase sensitivity to gram negative decrease
  gram positive.

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Cephalosporins

• Actions
• Affect cell wall
• Typically bactericidal
• Adverse reactions
• Gastrointestinal disturbances
• Hypersensitivity
• Headache, dizziness, nephrotoxicity, malaise,
  fever
• Bacteria or fungal superinfection

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Broad-Spectrum Antibiotics

• Tetracyclines, Macrolides, and Lincosamides
• Tetracyclines
• Anti-infectives natural and synthetic compounds
• Treatment of cholera, Rocky Mountain spotted
  fever.
• May cause permanent discoloration of teeth
  children under 9.
• Macrolides
• Effective against a wide variety of pathogenic
  organisms especially infections of respiratory
  and genital tracts.
• Treatment of gram-negative and positive organisms.

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Broad-Spectrum Antibiotics

• Tetracyclines, Macrolides, and Lincosamides
• Lincosamides
• Anti-infectives effective against gram-positive
  and gram-negative bacteria (streptococci and
  staphylococci).
• High potential for toxicity limits use.

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