Poster Title

1
SUN-262
THE EFFECTS OF INTERMITTENT VITAMIN D3
SUPPLEMENTATION ON MUSCLE STRENGHT AND METABOLIC
PARAMETERS IN POSTMENOPAUSAL WOMEN WITH TYPE 2
BIABETES A RANDOMIZED CONTROLLED STUDY
www.ued-ham.org.br
Roseane Silva, Luiz Griz, Juliana Maia, Manoel
Soares Filho, Maria Paula Bandeira, Francisco
Bandeira
Division of Endocrinology, Diabetes and Bone
Disease, Agamenon Magalhães Hospital, University
of Pernambuco Medical School, Recife, Brazil
INTRODUCTION
Figure 1. Handgrip strenght in the right arm
before and after vitamin D suplementation
8.67 2.41 , p0.1), serum triglycerides
(175.68 86.5 to 169.63 62.17 mg/dl, p0.9),
SBP (136.3 12.7 to 139.42 4.2 mmHg, p0,4)
and DBP (81.3 7.4 to 83.0 10.0 mmHg, p0.4)
with vitamin D supplementation. SBP increased
significantly in the control group from 136.6
18.6 to 141.4 17.6 mmHg (p0.04).
The association between vitamin D deficiency and
the development of metabolic syndrome and type 2
diabetes as well as decreased skeletal muscle
mass has been reported but the effects of vitamin
D supplementation on these parameters is still
controversial.
CONCLUSION
OBJECTIVE
Vitamin D3 supplementation in doses equivalent to
942 IU/day improved isometric handgrip strength
but had no effect on glycemic control in
postmenopausal women with longstanding type 2
diabetes.
To evaluate the effect of weekly vitamin D3
supplementation on metabolic parameters and
muscle strength of postmenopausal women with type
2 diabetes.
Table 1. Caracteristics of study patients
p 0.101
p 0.002
METHODS
Figure 2. Handgrip strenght in the left arm
before and after vitamin D suplementation
38 patients with serum 25OHD lt 30 ng/ml were
randomly assigned to oral vitamin D3 (6600IU/week
in 2 cc oil preparation) or 2cc olive oil weekly
for 3 months with the study medication being
administered under supervision in all subjects.
RESULTS
Baseline characteristics in the intervention and
control groups were age 62.16 7.62 vs 62.32
8.00 years (p 0.9), diabetes duration 11.1 7.4
vs 8.95 7.4 years (p0.36), BMI 27.6 5.3 vs
28.2 5.9 Kg/m2 (p0.6), HbA1c 8.18 2.13 vs
9.13 2.12 (p 0.15), serum 25OHD 22.24 3.98
vs 22.91 4.21 ng/ml (p0.6), with differences
in sun index, BP, FPG, and serum lipids. At the
end of treatment period 26 of the intervention
and 48 of the control groups had 25OHD lt 20
ng/ml. Handgrip strength improved significantly
in the intervention group (right arm 17.4 2.68
to 19.9 3.53 Kg, p 0.002 left arm 16.31 2.6
to 18.46 3.2 Kg, plt 0.001) but not in the
control group (right arm 16.87 3.99 to 17.93
 4.91 Kg, p 0.101 left arm 16.13 4.29 to
16.86   4.79 Kg, p 0.229). There were no
significant differences in the distribution of
BMI at baseline but more patients in the control
group became obese at the end of the study period
(p0.014). There were no significant changes in
mean FPG (155.5 67.4 to 163.4 87.9 mg/dl,
p0.7), PPG 213.5 87.7 to 210.7 68.8 mg/dl,
p0.8), HbA1c (8.18 2.13 to
p lt 0.001
p 0.229
REFERENCES
1- Suzuki A, Kotake M, Ono Y, et al.
Hypovitaminosis D in type 2 diabetes mellitus
Association with microvascular complications and
type of treatment. Endocrine Journal. 200653(4)
503-10. 2- Palomer X, González-Clemente JM,
Blanco-Vaca F, et al. Role of vitamin D in the
pathogenesis of type 2 diabetes mellitus.
Diabetes, Obesity and metabolism.
200810185-97. 3- Bandeira F, Griz L, Dreyer P,
et al. Vitamin D deficiency a global
perspective. Arq Bras Endocrinol Metab.
200650(4)640-46.
DATA EXPRESSED AS MEAN ( SD) FOR CONTINUOUS
VARIABLES