Figure 1

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Supplemental Figure S1
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Supplemental Figure S2
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Supplemental Figure S3
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Supplementary Figure S4
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Supplemental Figure S5
A. Colon26
B. Tubo.A5
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Supplemental Figure S6
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Serum drug levels (ug/ml) /- SEM Serum drug levels (ug/ml) /- SEM Serum drug levels (ug/ml) /- SEM
Dose (mg/kg) Cmax Steady state Cmin 2 weeks post final dose
50 1114.37 54.88 1621.36 310.35 1292.29 67.82
10 219.21 33.66 273.67 17.35 188.35 5.48
3 25.03 8.46 3.45 0.82 ltLLQ
1 5.72 4.98 ltLLQ ltLLQ
0.3 ltLLQ ltLLQ ltLLQ
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Supplementary Figure S7
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Supplementary Figure S8

• T cells
• Tumor Associated Macrophage
• Tumor Cells

Proteolytic cleavage by MT1-MMP
SEMA4D
1
2
ErbB2 MET
PLXNB1
Transactivation
P
PDZ-RhoGEF/ or RhoGAP
APC Tumor Cells Endothelial Cells
RhoA
Cytoskeletal reorganization and migration Tumor
growth and metastasis