?????????? (Drugs acting on the respiratory system)

1
?????????? (Drugs acting on the respiratory
system)
2
?
?
?
3
???????????????
??
?????
??
4
ß?????
??
ATP
cAMP
5AMP
?????
?????
GTP
cGMP
?????
M?????
5
?.??? (antiasthmatic drugs)
1. ?????????
???? (adrenaline) 1.????????ß2 2.????????
6
3. ??a???????????,???? ??????? ????
???????? ???????
7
??? (ephedrine) ???????,??a?ß?? ???????? ??
????????? ????
8
??????(isoprenaline) ??ß1?ß2 ??????? ?????
???????? ???????
9
???? (salbutamol)
???? (terbutaline)
???? (clenbuterol)
?????ß2?? ??????? ????????
10
???????? ????????? ?????,??????????l/10???????
11

• 2 ?? (theophylline)
• ???????(PDE)
• ????????
• ??????
• ???????

12
?????????? ???????,?????????
13
??M?????(anticholinergics) ????(ipratopine)
??M??  ???? ?????????
14
???????(glucocorticoids) ????(beclmethasone)
???????? ???? ?????????? ????
15
???????????(inhibitors of mediators release)
???? (cromolyn sodium)
???????,???????? ?????? ??????????
16
??? (antitussives)
1 ??????
??????
2 ??????
???????????????????
17
??? ????????,????,?????????,?????????
????????,???????
18
????(???) ????????,??????? l/3????????????
??????????????????????
19
????????? ???? ??,???????????????????????????,???
?????????????????
20
?????? ????(???) ?????,?????????????? ????????????
????????
21
??? 1 ??? ??????????,?????,?????
???????????????
22
2 ?????? ??????,????????????,???????,??????????
??????????????
23
????????,???????????????????????,???????,?????????
?
24
3.??? ??????????,??????,??????????????????????,???
?????????????????
25
??? 1.???????????????????? 2.????????????????????
???????????????????
26
3.????????,?????????????????? 3.?????????,???????
27
??????? ??? (Drugs acting on the
gastrointestinal system)
28
????
????
gt
?????
??
??
HCO3??
????
29
???????(Drugs used for peptic ulceration)
30
?????(antacids) ??????????????,????????,????????
??
31
????????
????
????
????
????
???
????
???
???
???
???
???
????
- - -
32
????
????
????
????
???
???
- - - -
?? CO2
- - -
????
??
??
??
??
???
33
???????
Ach
????
MR
H
Ca2
??
H- K ATP?
????
H2R
cAMP
????
GR
Ca2
???
K
????
34
1.M?????(muscarinic antagonists) ????
(pirenzepine) ?????????M1??, ???? ?????????,??????
??
35
2.H2????? (H2 receptor antagonists)
???????????H2??,????? ,????????????????????????
??????
36
???? (cimetidine) (????,???)
????????,???????????? ?-???????????????????
37
??????

• ????????
• ?????????????????????
• ????? ??????,????,?????
• ??????? ?????????????????????

38
????(ranitidine) ??????????????????????,??????????
??,??????????
39
H2?????
H2????
????
T1/2(h)
?? ????????????
1
1.52.3

410
1.62.4

2050

2.54
40
3.H???? (proton pump inhibitors)
??????H???,???????
41
???? (omeprazole???) ??????Ach???????????????,???
??????? ???????? ??????????
42
???? ??????????? ?????? ?????
43
??????
???????????,????????????????????
?????????????,??????????
44
?????(mucosal strengtheners)
1 ??????? ?????(misoprostol) ???? (enprostil)
45
??????????????? ?????????????NSAIDs?????????
46
???????????????????,?????
47

• 2 ??? (sucralfate)
• ? pHlt4??????????????,??????
• ??PG??,????????????
• ??????

48
????????????????????? ??????(pHlt4)???,?????????
????????
49
3.?????(colloidal bismuth subcitrate) ???
pH???????????????????,????????,??????,?????????
50
??????? ???????????????,?????????????????23???
????
51
?.???????
???? ????????????????????????????,?????????????,?
??????????,?????
52
??? ????????????,?????????????????????????????????
??,???????
53
?????
????????????
54
??? ?????(???) ?? CTZ? D2??,????????????DA??,?????
????,??????????
55
????????????????????????, ????????????????????????
??
56
???? (???)
????????????????5HT3?? ?????????
57
????????????????????????????????????? ??????,?????
?????????
58
????(???) ????DA??,??????????
59
????? ??? ???????,????????????,????,????????????
60
???? ?? ????????????????????????? ?????????????
???????????
61
????? ??????,??????????,????? ???????
62
????? ?? ??? ???????? ????????? ???????
63
????? ???? ??????? ???????????????
64
?? ??????????,???????? ?????????
65
???????? 1.???? ?????????????,????????
66
2.?????????????????,???????????????????,??????????
??????????,?????????
67
3.???????????????????????????????????????????
68
??? ??????????????????? ???????????????,????
???????????????????
69
????????????,??????????,?????????????????????????
???????????????
70
????????????? ??????????????????,?????,????,????
????????
71
??? 1.?????????????????????????????????? 2.??????
???????? 3.????????????????????
72
??2
73
??1