IMMUNIZATION: CONCEPTS

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www.vaccinationcouncil.org
This vaccine webinar series is provided as a
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Source www.homefirst.com
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A Medical School Professor of Immunologys Lesson
for All PhysiciansNEUROIMMUNOLOGY PATTERNS OF
INTERFERENCEStephen C. Marini, M.S., D.C., Ph.D

• Stephen C. Marini, M.S., D.C., Ph.D
• Family
• Chiropractic Center
• 3301 Ryan Avenue
• Philadelphia, PA 19136
• Tel [phone]
• Fax [phone]

Ciccarone Chiropractic Rehab Centers 144 East
DeKalb Pike, Suite 202 King of Prussia, PA
19406 Tel [phone] Fax (610)
337-8235 E-Mail MOTOMARINI_at_MSN.COM
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CHANGING PARADIGMS
Mechanistic
CHEMISTRY STRUCTURE
FUNCTION
Vitalistic
ENERGY FIELD CHEMISTRY
STRUCTURE
UNIFIED
FIELDS FUNCTION
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The Current Consensus Model of the Immune System
and Its Relationship to the Neuroendocrine System
Immune System
Cell-Mediated Immunity Cellular Cytotoxicity DTH
Humoral Immunity Antibodies
T Helpers Cytokines
Neuro-endocrine System
Antigen-presenting Cells
Stem cells, Cytokines
Reticuloendothelial System
Haemopoietic System
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Regulation of Immune Responses and the
Involvement of Other Systems
Immune System
Haemopoietic System
Positive Regulators T Helpers
Cell-Mediated Immunity Cellular Cytotoxicity DTH
Humoral Immunity Antibodies
Reticulo-endothelial System
Negative Regulators T Suppressors
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OPTIMUM IMMUNITY
THE HUMAN IMMUNE SYSTEM YOUR MOST RESPONSIVE
ALLY PNI (Psychoneuroimmunology) PSYCHO
Experience, Interpretation, Translation,
Transformation, Mind, Thoughts, Feelings,
Notions, Memory, Opinions, Spirit, Soul,
Energy-information, Unified Fields NEURO Brain
(right and left), Spinal cord, Cranial nerves,
Spinal nerves, Autonomic nervous system, Memory,
Neurotransmitters, Neuropeptides, Neurohormones,
Interference by the VSC (Vertebral Subluxation
Complex) IMMUNO Central and peripheral
lymphoid organs, T cells, B cells, Antigen
processors, Lymphokines, Cytokines,
Neurochemicals, Memory GASTROENTERO Gut
associated lymphoid tissues, Lymphokines,
Neurotransmitters, Breast feeding, Oral
tolerance, Memory, Gut reactions MUSCULOSKELETAL
Receptors, Biomechanics, Posture, Memory,
Spinal Learning, Interference from VSC, Exercise
Neurochemistry
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Rationale For Immunization
Immunoprophylaxis/Primary Prevention Herd
Immunity Pre Post Exposure Immunization
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TYPES OF IMMUNITY IMMUNIZATION
Active Passive Natural Artificial
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T HELPER CELL SUBSETS
Th 1 Cells (CD4) These cells mediate
functions connected with cytotoxicity and local
inflammatory reactions. Th 1 cells promote
development of Tc Cells, the expression of the
delayed hypersensitivity, and the production of
1gG2a. This subset secretes gamma interferon,
interleukin 2,3 tumor necrosis factor,
lympotoxin, and antibody mediated cell
cytotoxicity. Regulation of the Th 2 reactions.

• Th 2 Cells (CD4)
• This subset directs immune responses toward
  production of IgE (atopic diseases), IgA, IgG1.
• Eosinophil proliferation via interleukin 5, and
  mast cells via Il-3 and 4. Th 2 cells secrete
  Interleukin 3,4,5,6,10. Interleukin 4,5,6
  stimulate antibody production.
• The Th subsets down-regulate one another
• Gamma interferon secreted from Th 1 cells
  suppresses the maturation of Th 2 cells and
  suppresses the enhancing effect of IL-4 produced
  by the Th 2 cells on IgE and IgG1 synthesis
• IL-10 secreted the Th 2 cells suppresses
  production of Th 1 cells
• Il-10 possesses cross-regulatory role of
  inhibiting cytokine synthesis by Th 1 cells

IMMUNOGENS ELICITING A STRONG CELL MEDIATED
RESPONSE WILL INHIBIT HUMORAL ACTIVITY STRONG
HUMORAL RESPONSES INHIBIT CELL MEDIATED RESPONSES
TO THE SAME ANTIGEN
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• Prenatal Skewing toward Th2
• Natural
• Artificial/Environmental

• Neonatal/Infantile Th1 Stimuli
• Birth Canal Flora
• Colostrum
• Breast Milk
• Prebiotics
• Probiotics
• Environmental exposure
• Viruses
• Gram negative bacteria
• Fungi

• Neonatal/Infantile Inhibitors to the Th1/Th2
  Balance
• C Sections
• Vaccinations
• Antibiotics
• Formula Feeding
• Dysbiosis

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JOURNAL ARTICLE ISSN 0367-6102 Country of
Publication JAPAN Database med93-95 Record 2
of 4 selected. Title Vaccine strategies
targeting helper T cell responses. Author Golding
B Scott DE Address Laboratory of Plasma
Derivatives, United States Food and Drug
Administration, Bethesda, Maryland 20892,
USA Source Ann N Y Acad Sci, 754(-VI-)126-37
1995 May 31 Abstract Vaccine strategies need to
take into account the balance of T helper subsets
they induce. TH1 cells, which secrete IFN gamma
and IL-2, are associated with CMI, rather than
humoral responses, and afford protection against
intracellular infections including parasites. In
contrast, TH2 cells secrete IL-4, IL-5, and
IL-10 elicit high-titer antibody responses and
poor CMI and are associated with susceptibility
to infection with intracellular pathogens.
Depending on the type of TH cell bias required,
it is possible to manipulate the immune response
to a protein or peptide by employing (1)
different adjuvants, (2) conjugating the protein
to various carriers, (3) immunizing in the
presence of cytokines, (4) using alternative
routes of administration, or (5) using different
forms or doses of antigen. To apply these
approaches to a particular vaccine, it is
necessary to identify which component of the
infection agent (e.g., envelope protein or
peptide) or allergen to target. Once the type of
TH cell response that is protective is
identified, it may be possible to combine a
protein with an adjuvant or link it to a carrier
that will promote responses towards the most
advantageous TH subset.
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PRIMARY SECONDARY IMMUNE RESPONSES
ANTIBODY FORMATION
A. Antibody Response following Immunization
1 Response
2 Response
Ab Concentration
75
IgG
IgM
195
5 10 15
20 25 30
35 40 45
1. A summary of the solvent features of the
primary secondary immune responses
DAYS
Characteristic Primary Response vs.
Secondary Response Dose of Immunogen Required
gt Induction Period lt Total Antibody
Produced lt Duration of Response
lt IgM antibody produced IgG antibody
produced lt
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VACCINE TYPES
Whole Organisms (Bacterial) Live
Attenuated Inactivated Tuberculosis
(BCG) Anthrax Typhoid Cholera Pertussis Pl
ague
Purified Macromolecules Toxoids (Inactivated
Exotoxin) Diphtheria Tetanus Capsular
Polysaccharides Haemophilus influenza, Type B
(HIB) Neisseria Meningitides Streptococcus
Pneumoniae Surface Antigens Hepatitis B
(Recombinant surface antigen) HbsAg
Viral Particles Live Attenuated
Inactivated Measles Hepatitis
A Mumps Influenza Rubella
Polio (IPV) Salk Polio (OPV) Sabin
Rabies Varicella Yellow
Fever Rotavirus
DNA Vaccines/Genetically Engineered Satellite DNA
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TYPICAL COURSE OF AN AUTISTIC PATIENT

1. Hepatitis B immunization at 12 hours after birth.
   DPT immunization at 4 and 8 weeks, oral polio
   immunization also at 4 and 8 weeks, again at 3
   months. Schedule now being changed children will
   receive 2 doses of live attenuated oral polio and
   2 doses killed polio oral polio can cause
   disease only killed polio is used in Europe.
2. Because of great decrease in cell-mediated
   immunity (CMI) in infants, the vaccines lower CMI
   further one decreases CMI by 50 two together
   by 70. Longest safety trail of the triple
   vaccine (MMR, all live attenuated viruses) was
   three weeks.
3. Repeated immunizations with 3 vaccines
   simultaneously, e.g., Pneumococcus, Haemophilus,
   etc. from 4 weeks to 12 to 18 months. Repeat DPT
   is given at 12 months. All these triple vaccines
   markedly impair CMI.
4. Resultant decrease in CMI predisposes to
   recurrent viral infections, especially otitis
   media, since CMI controls response to viruses
   (also fungi e.g., Candida, parasites e.g.,
   leishmaniasis, mycobacterium e.g.,
   tuberculosis, even if drug resistant and
   leprosy).
5. When infections occur, bacterial cultures rarely
   performed, yet infants repeatedly given
   antibiotics. Antibiotics are of absolutely no
   help in viral infections in some countries,
   antibiotic administration without a prior culture
   is considered malpractice.
6. Antibiotics wipe out helpful bacteria in the gut
   (e.g., lactobacilli, bifidobacteria), which have
   important protective functions, including
   prevention of infection by yeast, pathogenic
   bacteria, and/or parasites. The protection is
   provided in part by the helpful bacteria clinging
   to the intestinal cell wall, thus preventing
   pathogenic microorganisms from getting to it.
   The pathogenic bacteria compete with the body for
   vitamin B-12 and perhaps other vitamins and
   minerals.

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Breast Feeding

• (PNIEG) -
• PSYCHO-
• NEURO-
• ENDOCRINO-
• IMMUNO-
• GASTROINTESTINO-
• NUTRITION
• BREAST MILK vs. FORMULA
• TOXICITY
• MOTHER FETUS
• MOTHER - BABY

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IMMUNIZATION QUESTIONS AND ISSUES

• Are vaccines effective?
• Temporary immunity/deferred susceptibility.
• 2. Are vaccines safe?
• Doctors, legislators, parents not informed.
• 3. Informed consent or conscription?
• 4. Avoid vaccine reactions by asking
• Is my child sick right now?
• Do I know if my child is at risk?
• History in family of vaccine reactions or health
  problems?
• Do I know the adverse reactions to the vaccines
  given to my child?
• Do I know the manufacturer and lot number of the
  vaccine?
• Do I know how to report an adverse reaction?
• 5. Do I know my rights under the state law to
  exempt my child from vaccines?
• 6. If I choose not to vaccinate my child, do I
  know how to recognize and appropriately manage
  illnesses that vaccines protect against?

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• CURRENT VACCINATION CONCERNS
• Emergency State Powers Act
• State Registry
• Exemptions Under the Law
• Thimerosal and Vaccines
• Autism and Vaccines
• Mercury Induced
• Autistic Enterocolitis
• Immune Complex Disorder

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Immunostasis
Th1/Th2 Balance
Th2 Up Regulators Vaccinations Antibiotics Emergen
cy Consciousness Sympathetic ActivityHPAC Purulen
t Parasitic Infection Trans Saturated Fats,
6EFA Oxidation Damage Mercury Toxicity Nicotine
and Caffeine Progesterone Sugar Environmental
Toxins, Hormones, Pesticides, Diesel Fumes Food
Deprivation
High Ratio FXN
Th1 Up Regulators Welfare Consciousness
Patterns Antioxidants Glucans Mushroom
Extracts Melatonin DHEA (Dehydroepinandrosterone)
Selenium, Zinc Probiotics Breast Feeding Fish
Oils Beta Sterols (Beta-sitosterol
sterolin) Viral and Bacterial Inf. Dirt, Dust,
Dander
Low Ratio FXN
CMI (Cell Mediated Immunity) Surveillance Toleranc
e Cytotoxicity Infection Externalization Intracell
ular Infection
Humoral Immune Atopic Dermatitis Allergies
Asthma Eczema/Psoraisis Infection
Internalization Toxin Neutralization Extracellular
Infection System Autoimmunity (Lupus, Graves,
Type II Diabetes, RA) Cancer AIDS
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MAP OF CONSCIOUSNESS God-view
Life-View Level Log Emotion
Process Self Is
Enlight- 700- Ineffable
Pure Con-
Enment 1000
sciousness All-Being
Perfect Peace 600
Bliss Illumination One
Complete Joy 540
Serenity Transfiguration Loving
Benign Love 500
Reference Revelation Wise
Meaningful Reason 400
Understanding Abstraction Merciful Harmonious
Acceptance 350 Forgiveness Trans-


cendence Inspiring Hopeful
Willingness 310 Optimism
Intention Enabling Satisfactory
Neutrality 250 Trust
Release Permitting Feasible
Courage 200 Affirmation Empowerment
Indifferent Demanding Pride
175 Scorn Inflation Vengeful
Antagonistic Anger 150
Hate Aggression Denying
Disappointing Desire 125 Craving
Enslavement Punitive Frightening
Fear 100 Anxiety
Withdrawal Disdainful Tragic
Grief 75 Regret
Despondency Condemning Hopeless
Apathy 50 Despair
Abdication Vindictive Evil
Guilt 30 Blame
Destruction Despising Miserable
Shame 20 Humiliation
Elimination POWER VS. FORCE David R. Hawkins,
M.D.,Ph.D.
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Health
Interference
Patterns of Interference
Symptoms
Symptom Constellations
Dis-ease
Disease
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HEALTH CARE ERAS
Era I Chemical, Mechanical, material or physical
medicine Described by being causal,
deterministic, hierarchical, bound to classical
concepts of space-time. Mind is not a factor
mind is purely the result of brain
mechanisms. Examples are any form of therapy
focusing solely on the effects of things
(chemical or physical) on the body. Almost all
forms of modern allopathic-drugs, surgery,
irradiation, etc.
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Era II Mind-Body medicine. The role of
energy/information on the physical-chemical body
is embraced. Described by the mind being a major
factor in healing WITHIN the single person mind
has causal powers. Healing not fully explainable
by classical concepts of science. Era 2 includes
but goes beyond Era 1. Examples are any therapy,
which has the patient as the focus, complementary
approaches are incorporated. Therapies
emphasizing the effect of consciousness solely
within the individual body psychoneuroimmunology,
chiropractic, hypnosis, homeopathy, acupuncture,
biofeedback, relaxation therapies, therapeutic
touch, and imagery based therapies.
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Era III Non-local therapy or Eternity
Medicine Described by the mind factoring into
healing both WITHIN and BETWEEN persons. Mind
not completely localized to points in space
(brains or bodies) or time (present moment or
single lifetimes). Mind is unbounded in space
and time and is ultimately unitary or one.
Distance healing possible. Not explainable by
classical concepts of space-time or
matter-energy. Examples are any therapy in which
effects of consciousness bridge between different
persons all forms of distant healing,
intercessory prayer, and transpersonal
imagery. DISEASES ARE SEEN AS IMBALANCES TO BE
CORRECTED. IMBALANCES AFFECT THE ENTIRE PERSON
(BOTH THE PHYSICAL BODY AND THE ENERGY BODY).
IMBALANCES HAVE THE CAPACITY OF AFFECTING THE
INDIVIDUAL AS WELL AS THOSE LINKED BY ENERGY.
PROPER HEALING NECESSITATES BALANCING ENERGY AS
WELL AS CHEMISTRY AND STRUCTURE OF THE BODY.
HEALTH AND HEALING CAN BE AFFECTED BY
ENERGY/INFORMATION FROM A DISTANCE. PRAYER HAS
BOTH A LOCAL AND NON-LOCAL EFFECT ON THE
MIND-BODY.
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HEALTH CARE ERAS
ERA I MEDICINE Allopathic Therapies Paradigm
CHEMISTRY ? STRUCTURE ? FUNCTION
ERA II MEDICINE Holistic/Holoenergetic
Therapies Paradigm ENERGY ? CHEMISTRY ?
STRUCTURE ? FUNCTION
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ERA III MEDICINE Intercessory Therapies Paradigm
UNIFIED ? ENERGY ? CHEMISTRY ? STRUCTURE ?
FUNCTION FIELDS