Short-term outcomes, methotrexate vs placebo in chronic HF

1
Short-term outcomes, methotrexate vs placebo in
chronic HF
Outcome Baseline 12 weeks p
NYHA class      
Methotrexate 2.9 2.4 lt0.01
Placebo 2.8 2.6 lt0.05
6-minute walk (min)      
Methotrexate 296.5 361.4 lt0.01
Placebo 288.4 321.8 lt0.05
Quality-of-life scores      
Methotrexate 82.4 92.0 lt0.01
Placebo 76.7 80.1
Physical-health scores      
Methotrexate 43.1 52.8 lt0.01
Placebo 39.2 43.6
Methotrexate, n30 placebo, n32 plt0.05 vs
placebo plt0.01 vs placebo
Gong K et al. Am Heart J 2006 151162-68.
New role for an old drug? Methotrexate shows
modest HF benefit in small study Rheumawire gt
News Jan 30, 2006