Shingles / herpes zoster

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Shingles / herpes zoster
Vaccination Vs Natural Immune System Function

• You can fool some of the people all of the time
  and all of the people some of the time, but you
  cant fool all the people all of the time. Abe
  Lincoln

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FDA approved Zostavax in the spring of 2006, the
vaccine halved the risk of getting shingles. Even
more impressive, it cut by two-thirds the risk of
developing post herpetic neuralgia,
Dr Ben Goldacre
Bad Science has sold over 400,000 copies, is
published in 18 countries, exposing bad
behaviour in the pharmaceutical industry will be
published in 2012 by 4th Estate.
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Cause Shingles is caused by the varicella zoster
virus, the same virus that causes chickenpox.
After a person recovers from chickenpox, the
virus stays in the body in a dormant (inactive)
state. For reasons that are not fully known, the
virus can reactivate years later, causing
shingles. Herpes zoster is not caused by the same
virus that causes genital herpes, a sexually
transmitted disease.
There are two ways to be fooled. One is to
believe what isn't true the other is to refuse
to believe what is true. ? Søren Kierkegaard
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Herpes zoster and shingles

• United States each year approximately 1,000,000
  individuals develop herpes zoster
• 20, or 200,000 individuals, develop
  postherpetic neuralgia
• Less than 10 percent of people younger than 60
  develop postherpetic neuralgia
• after a bout of HZ, while about 40 percent of
  people older than 60 do
• Disease incidence 20-30 over 60yo
• Vaccine works 55 of the time
• 99 of shingles patients have only 1 episode

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• Recap
• 300,000,000 Americans
• 1,000,000 will get herpes zoster 1 in 300
• 200,000 will get post herpetic neuralgia
• 110,000 may be helped by the shot 0.003
• Of those 99 will have 1 occurrence
• Shot is 150 - 300 per shot

But Is It Covered By Insurance ???
But Is It Covered By Insurance ???
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Mechanism of activation Unless the immune system
is compromised, it suppresses reactivation of the
virus and prevents herpes zoster. Why this
suppression sometimes fails is poorly understood,
but herpes zoster is more likely to occur in
people whose immune system is impaired due to
aging, immunosuppressive therapy, psychological
stress, or other factors. Upon reactivation,
the virus replicates in the nerve cells, and
virions are shed from the cells and carried down
the axons to the area of skin served by that
ganglion. In the skin, the virus causes local
inflammation and blisters. The short- and
long-term pain caused by herpes zoster comes from
the widespread growth of the virus in the
infected nerves, which causes inflammation.
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• deliberately induced immunosuppression
• body from rejecting an organ transplant
• bone marrow transplant
• rheumatoid arthritis
• Crohn's disease
• splenectomy
• radiation
• chemotherapy
• Lupus

Cortisone

• Non-deliberate immunosuppression
• malnutrition
• aging
• many types of cancer
• leukemia
• lymphoma
• multiple myeloma
• chronic infections

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One study example Shingles Prevention Study
(SPS) in Subjects 60 Years of Age and Older (What
is the Placebo Ingredients) Efficacy of ZOSTAVAX
was evaluated ZOSTAVAX (n19,270) or placebo
(n19,276). Subjects were followed for the
development of zoster for a median of 3.1 years
(range 31 days to 4.90 years). The study
excluded people who were immunocompromised or
using corticosteroids on a regular basis, anyone
with a previous history of HZ, and those with
conditions that might interfere with study
evaluations, including people with cognitive
impairment, severe hearing loss, etc
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Whats in Placebos Who Knows? Analysis of
Randomized, Controlled Trials the Annals of
Internal Medicine 2008

• Dr. Beatrice Golomb
• there isnt anything actually known to be
  physiologically inert. On top of that, there are
  no regulations about what goes into placebos, and
  what is in them is often determined by the makers
  of the drug being studied, who have a vested
  interest in the outcome. And there has been no
  expectation that placebos composition be
  disclosed.
• example type 2 diabetes drug
• placebo A (composed of Peanut oil, high in B3)
• placebo B (composed of Corn Oil, low in B3).
• The results
• significant improvement compared to placebo A
• no improvement against placebo B.
• B3 aggravated diabetes
• placebo A ,making the drug appear more effective
  than it really is.

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• Deaths in the approved Study (What is in the
  Placebo???)
• The incidence of death was similar in the groups
  receiving ZOSTAVAX or placebo during the Days
  0-42 postvaccination period
• 14 deaths occurred who received ZOSTAVAX
• 16 deaths occurred who received placebo.
• most common death was cardiovascular disease (10
  in the group of subjects who received ZOSTAVAX, 8
  in the group of subjects who received placebo).

In the ZEST study, serious adverse events
occurred at a similar rate in subjects vaccinated
with ZOSTAVAX (0.6) or placebo (0.5) from Days
1 to 42 postvaccination.
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Shot ingredients and Storage
Storage ZOSTAVAX must be stored frozen between
-58F and 5F (-50C and -15C). Use of dry ice
may subject ZOSTAVAX to temperatures colder than
-58F (-50C). Before reconstitution, ZOSTAVAX
SHOULD BE STORED FROZEN at a temperature between
-58F and 5F (-50C and -15C) until it is
reconstituted for injection. Any freezer,
including frostfree, that has a separate sealed
freezer door and reliably maintains a temperature
between -58F and 5F (-50C and -15C) is
acceptable for storing ZOSTAVAX.
ZOSTAVAX is a lyophilized preparation of the
Oka/Merck strain of live, attenuated
varicella-zoster virus Each 0.65-mL dose
contains a minimum of 19,400 PFU (plaque-forming
units) of Oka/Merck strain of VZV when
reconstituted and stored at room temperature for
up to 30 minutes. Each dose contains 31.16 mg
of sucrose, 15.58 mg of hydrolyzed porcine
gelatin, 3.99 mg of sodium chloride, 0.62 mg
of monosodium L-glutamate, 0.57 mg of sodium
phosphate dibasic, 0.10 mg of potassium
phosphate monobasic 0.10 mg of potassium
chloride residual components of MRC-5 cells
including DNA and protein and trace quantities
of neomycin and bovine calf serum. The product
contains no preservatives.
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• Natural Protection
• The peculiar age distribution of zoster may in
  part reflect the frequency with which the
  different age groups encounter cases of varicella
  and because of the ensuing boost to their
  antibody protection have their attacks of zoster
  postponed.
• contact with children with chickenpox boosts
  adult cell-mediated immunity to help postpone or
  suppress shingles,
• adults in households with children had lower
  rates of shingles than households without
  children
• indicated that pediatricians reflected incidence
  rates from 1/2 to 1/8 that of the general
  population their age

Thomas SL, Wheeler JG, Hall AJ (2002). "Contacts
with varicella or with children and protection
against herpes zoster in adults a case-control
study". Lancet 360 (9334) 678682
Terada K, Hiraga Y, Kawano S, Kataoka N (1995).
"Incidence of herpes zoster in pediatricians and
history of reexposure to varicella-zoster virus
in patients with herpes zoster". Kansenshogaku
Zasshi 69 (8) 908912.
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• A 2006 study found that fresh fruit is associated
  with a 300 reduced risk of developing shingles
• people who consumed less than one serving of
  fruit a day had a risk three times as great as
  those who consumed more than three servings
• For those aged 60 or more, vitamins and
  vegetable intake had a similar association.

Thomas SL, Wheeler JG, Hall AJ (2006).
"Micronutrient intake and the risk of herpes
zoster a case-control study". Int J Epidemiol 35
(2) 30714.
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Engerix-B Vaccine Study Adults 20 ugm 7
months 2,284 mIU/ml 20 ugm 13 months 9,163
mIU/ml Adolecents 10 ugm 8 months 1.989
mIU/ml 20 ugm 8 months 7,672
mIU/ml Infants 10 ugm 4 months 2,942
mIU/ml 10 ugm 7 months 713 mIU/ml
even though the data regarding the relation
between vaccination and autoimmune disease is
conflicting some autoimmune phenomena are clearly
related to immunization J.Autoimmun. 2000 feb
14(1) 1-10
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Vaccinations and Molecular Mimicry

• molecular mimicry is an important factor in
  autoimmune disease
• first published in 1985 and since that time
  substantial evidence has accumulated
• causing many autoimmune diseases including
  diabetes, lupus, scleroderma, rheumatoid
  arthritis, multiple sclerosis, chronic fatigue
  syndrome, autism
• even though the data regarding the relation
  between vaccination and autoimmune disease is
  conflicting some autoimmune phenomena are clearly
  related to immunization
• J.Autoimmun. 2000 feb 14(1) 1-10

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5 year old vaccinations stopped at 3 yo speech
and impulse control problems
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Flu Deaths under 5 and effective shots?
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Cdc website lies
Tetanus is a severe, often fatal disease. ..
Approximately 20 percent of reported cases end in
death. Tetanus in the U.S. is primarily a disease
of adults, but unvaccinated children and infants
of unvaccinated mothers are also at risk for
tetanus and neonatal tetanus, respectively. .
The National Health Interview Survey found that
in 1995, only 36 percent of adults 65 or older
had received a tetanus vaccination during the
preceding 10 years. Worldwide, tetanus in
newborn infants continues to be a huge problem.
Every year tetanus kills 300,000 newborns and
30,000 birth mothers who were not properly
vaccinated. Even though the number of reported
cases is low, an increased number of tetanus
cases in younger persons has been observed
recently in the U.S. among intravenous drug
users, particularly heroin users. Tetanus is
infectious, but not contagious, so unlike other
vaccine-preventable diseases, immunization by
members of the community will not protect others
from the disease. Because tetanus bacteria are
widespread in the environment, tetanus can only
be prevented by immunization. If vaccination
against tetanus were stopped, persons of all ages
in the U.S. would be susceptible to this serious
disease.
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History of tetanus During the mid-1800s, there
were 205 cases of tetanus per 100,000 wounds
among U.S. military personnel. By the early
1900s, this rate had declined to 16 cases per
100,000 wounds 92 percent reduction During the
mid-1940s, the incidence of tetanus dropped even
further to .44 cases per 100,000 wounds. 99
percent reduction Better wound hygiene
2002 there were 25 cases of tetanus and 3 deaths
reported in the U.S. Tetanus is a serious
problem in underdeveloped countries Newborn
babies born in unsanitary conditions whose
umbilical cords can become infected with tetanus
20
1994 the Institute of Medicine concluded that
there is compelling scientific evidence to
conclude that tetanus, DT and Td vaccines can
cause Guillain-Barre syndrome including death
brachial neuritis and death from anaphylaxis
(shock).
21
Institute Of Med 1994
Because either no studies or too few scientific
studies had ever been conducted to investigate
tetanus, DT or Td reactions, a determination
could not be made as to whether DT, Td or tetanus
vaccine can cause other serious health problems
which are reported following tetanus
vaccination residual seizure
disorders demyelinating diseases of the central
nervous system transverse myelitis optic
neuritis acute disseminated encephalomyelitis pe
ripheral mononeuropathy arthritis, and
erythema multiforme (lesions of the skin or
mucous membranes).
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78 years with immune system problems multiple
medications, low energy, poor health
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THE POWER OF Plants
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Keys to Restore maintain health
Proper nerve supply Get Checked for
Subluxation Regular Exercise Proper
Nutrition Sufficient Rest Prayer and Meditation
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