Chapter 12-1 DNA Part 1

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Chapter 12-1DNAPart 1
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I. Griffith and Transformation (1928)

• A. Griffith wanted to know how (which)
• bacteria caused pneumonia
• B. Isolated 2 strains of bacteria
• 1. Smooth bacteria- caused pneumonia
• 2. Rough bacteria- did not cause
• pneumonia

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• C. Experiment
• 1. Smooth bacteria- injected into mice?
• 2. Rough bacteria- injected into mice?

mice die
mice live
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• 3. Heat killed smooth bacteria- injected into
  mice
• 4. Mixed heat killed smooth bacteria with rough
  bacteria- injected into mice

mice live
mice die
X X
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• 5. Conclusion The rough (harmless) strain of
  bacteria had been transformed into the
  disease-causing strain.
• A transformation
• had occurred.
• 6. Griffith thought the transforming factor might
  be a gene.

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Experiment 3
Experiment 4
Experiment 1
Experiment 2
Inject mouse with _______________ bacteria
Inject mouse with ________________ And
____________ bacteria
Inject mouse with ________bacteria
Inject mouse with ________bacteria
Heat killed smooth
Heat killed smooth
rough
smooth
rough
Lives ?
Lives ?
Dies ?
Dies ?
Mouse _________
Mouse _________
Mouse _________
Mouse _________
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