Christine Ortiz, Associate Professor

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Christine Ortiz, Associate Professor Department
of Materials Science and Engineering Massachusetts
Institute of Technology MIT-DMSE, Assistant
Professor (1999-2004) MIT-DMSE, Associate
Professor without Tenure (2004-2006) MIT-DMSE,
Associate Professor with Tenure
(2006-present) CAREER DEVELOPMENT COMMITTEE
Prof. Yet-Ming Chiang Prof. Michael Cima Prof.
Bernie Wuensch May, 2009
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RESEARCH PROGRAM OF CHRISTINE ORTIZ
NANOMECHANICS OF STRUCTURAL BIOLOGICAL MATERIALS
-nanoscale forces and displacements (F, d),
constitutive laws (s/e) -local,
spatially-specific material properties (E, sY, H,
energy dissipation, etc.) -molecular-level
structure-property relationships -novel
mechanical phenomena (e.g. nanogranular friction,
fracture localization, etc.)
Musculoskeletal (internal to the body) (e.g.
cartilage, bone, etc.)
Exoskeletal (external to the body) (e.g.
gastropod molluscs, armored fish, etc.)
Medical motivation -to facilitate the
development of improved clinical treatments for
disease injury through tissue repair and/or
replacement? regenerative medicine / tissue
engineering
Engineering motivation -Bio-inspiration and
guidance for improved materials for protective
and structural applications
Multiscale Approach single molecules ?biomimetic
assemblies ? matrix of single cells ? in-tact
tissue
Objective A Fundamental, Mechanistic-Based
Understanding of Tissue Function, Quality, and
Pathology
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RESEARCH PROGRAM OF CHRISTINE ORTIZ
NANOMECHANICS OF STRUCTURAL BIOLOGICAL MATERIALS
matrix
(Buschmann)
SELECTED RECENT ACCOMPLISHMENTS
(MUSCULOSKELETAL) ? Prior to tenure established
the use of nanomechanics in near-physiological
conditions applied to healthy musculoskeletal
tissues ? Post-tenure application of
nanomechanics to the field of tissue engineering
temporal evolution of the quasistatic mechanical
properties (Ng J. Biomech. 2007) and dynamic
visco(poro)elasticity (Lee Trans. ORS 2008) of
the tissue engineered cartilage matrix associated
with individual cells ? ? Assessment of
engineered tissue quality and heterogeneity
locally at unprecedented resolutions as a
function of cell type, scaffold, growth factors,
etc. ? Relevance to mechanotransduction COLLABORA
TORS ? A.J. Grodzinsky (MIT-BE), S. Chubinskaya
(Rush U.), Anna Plaas (Rush U.), John Sandy (Rush
U.), Peter Roughley (Shriners Hospital for
Children, Montreal, Canada )
AFM colloidal tip
chondrocyte, stem cell
viscoelasticity poroelasticity
10 µm
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RESEARCH PROGRAM OF CHRISTINE ORTIZ
NANOMECHANICS OF STRUCTURAL BIOLOGICAL MATERIALS
SELECTED RECENT ACCOMPLISHMENTS
(MUSCULOSKELETAL) ? Prior to tenure established
the experimental and theoretical methods for high
resolution imaging and nanomechanics of bone ?
Post-tenure Postulated a new theory for the
strength on bone involving "nanogranular
friction" (Tai Nano Lett., 2006, featured in
Nat. Nanotech. News and Views, 2006, commentary
J. Am. Acad. Ortho. Surg. 2007) discovered a new
energy dissipation mechanism in mineralized
biological tissues nanoscale heterogeneity (Tai
Nat. Mater. 2007)?assessed nanoscale properties
of stem cell-based tissue engineered bone (Tai
J. Biomech., Pelled Tiss. Eng. 2008). ? ?
Understanding the mechanisms that prevent our
bones from fracturing under physiological loading
will aid in the treatment of problems that result
from old age, disease, and injury. COLLABORATORS
? F. Ulm (MIT-CEE), S. Suresh (MIT-DMSE), D.
Gazit (Hebrew U.)
FEA f15º, c 100 MPa
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RESEARCH PROGRAM OF CHRISTINE ORTIZ
NANOMECHANICS OF STRUCTURAL BIOLOGICAL MATERIALS
cross section of fish scale
SELECTED RECENT ACCOMPLISHMENTS (EXOSKELETAL) ?
Prior to tenure established an experimental and
theoretical framework for studies of mineralized
biological materials at the nanoscale, using
nacre as a model system ? Post-tenure Determined
multilayered design (i.e. thickness, sequence,
and material properties of individual layers) of
a natural armor which facilitate circumferential
fracture and prevent interfacial delamination
under a penetrating load (bite from predator) in
order to localize impact and prevent catastrophic
failure (Bruet Nat. Mater. Cover 2008) ? ?
Bio-inspiration and guidance for improved
materials for protective and structural
applications (Ortiz Science 2008) COLLABORATORS
? M.C. Boyce (MIT MechE)
Ganoine Dentin Isopedine Bone
penetration on top of fish scale
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RESEARCH PROGRAM OF CHRISTINE ORTIZ
NANOMECHANICS OF STRUCTURAL BIOLOGICAL MATERIALS
SELECTED RECENT ACCOMPLISHMENTS (EXOSKELETAL) ?
Defense Science Study Group (DSSG) 2008-2009 ?
Department of Defense National Security Science
and Engineering Faculty Fellows (468 white papers
resulted in 17 semifinalists being invited to
submit full proposals and in person interviews ?
10 awardees selected)? 4.6M total ? MIT
Institute for Soldier Nanotechnologies (Member,
2002-present) ? Raytheon, Inc.
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THESIS SUPERVISED BY CHRISTINE ORTIZ
Supervised a Total of 60 Students
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SELECTED ORTIZ GROUP ALUMNI
RD ? Monica Rixman (Provex Technologies, Dexcom
Technology for Diabetes) ? Laurel Ng (Titan
Corporation) ? Jae Choi (MIT Center for Cancer
Research) ? Jennifer Vandiver (Alkermes) ? Dong
Zhang (Heraeus, Inc.) ? Miao Ye ( Proctor
Gamble) Intellectual Property ? Kuangshin Tai
(Wolf, Greenfield, and Sacks Intellectual
Property Law Firm) Financial ? Lin Han (Aristeia
Capital) Tenure-Track Faculty ? Joonil Seog
(University of Maryland College Park, Materials
Science and Bioengineering) ? Delphine Dean
(Bioengineering Dept.,Clemson University, NC) ?
Kristin Domike (College of Wooster, OH) ? Hang
Qi (University of Colorado) ? Mariselma Ferreira
(Universidade Federal do ABC, Sao Paulo,
Brazil) Graduate School (UROPs, B.S. Thesis) ?
Rafael Bras (Northwestern), Lauren Frick
(MIT-BE), Shikha Gupta (Berkeley), Patty
Chen (Whitaker College Health Sciences and
Technology), George Gluck (NYU Medical
School), Elissa Robbins (Yale), Krista Niece
(Northwestern), etc.
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PUBLICATIONS IN REFEREED JOURNALS OF CHRISTINE
ORTIZSINCE TENURE (16)
1. Dean, D., Han, L., Grodzinsky, A. J. and C.
Ortiz, Compressive Nanomechanics of Opposing
Aggrecan Macromolecules, Journal of Biomechanics
39(14), 2555-2565, 2006. 2. Vandiver, J.,
Dean, D., Patel, N., Botelho, C., Best, S.,
Santos, J. D., Lopes, M. A., Bonfield, W. and C.
Ortiz, Silicon Addition to Hydroxyapatite
Increases Nanoscale Electrostatic, Van der Waals,
and Adhesive Interactions, Journal of Biomedical
Research Research A 78A(2), 352-363, 2006. 3.
Qi, J.H., Ortiz, C. and M. C. Boyce, Mechanics
of Biomacromolecular Networks Containing Folded
Domains, Journal of Engineering Materials and
Technology 128(4), 509-518, 2006. 4. Oyen,
M.L., Bushby, A.J., Mann, A. and C. Ortiz,
Mechanics of Biological and Biomimetic Materials
at Small Length Scales, Journal of Material
Research 21(8), 1869-1870, 2006.
OUTGROWTH OF STUDENT SUPERVISED RESEARCH
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PUBLICATIONS IN REFEREED JOURNALS OF CHRISTINE
ORTIZSINCE TENURE (16)
5. Tai, K. Ulm, F.J. and C. Ortiz, Nanogranular
Origins of the Strength of Bone, Nano Letters
6(11), 2520-2525, 2006 (Featured in J. Thomas,
Biomaterials Close to the Bone, Nature
Nanotechnology News and Views 1(2), 99, 2006.
Commentary in D. Fyhrie, Rocks in a Bag,
Journal of the American Academy of Orthopaedic
Surgeons 14(4), 257, 2007).
OUTGROWTH OF STUDENT SUPERVISED RESEARCH
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PUBLICATIONS IN REFEREED JOURNALS OF CHRISTINE
ORTIZSINCE TENURE (16)
6. Pelled, G., Tai, K., Sheyn, D., Zilberman, Y.,
Kumbar, S., Nair, L. S., Laurencin, C. T., Gazit,
D. and C. Ortiz, Structural and Nanoindentation
Studies of Stem Cell-Based Tissue-Engineered
Bone, Journal of Biomechanics 40(2), 399-411,
2007. 7. Han, L., Dean, D., Ortiz, C. and A.
J. Grodzinsky, Lateral Nanomechanics of
Cartilage Aggrecan Macromolecules, Biophysical
Journal 92(4), 1384-1398, 2007. 8. Ng, L.,
Hung, H, Sprunt, A., Chubinskaya, S., Ortiz, C.
and A. J. Grodzinsky, Nanomechanical Properties
of Individual Chondrocytes and Their Developing
Growth Factor-Stimulated Pericellular Matrix,
Journal of Biomechanics 40(5), 1011-1023, 2007.
9. Tai, K., Dao, M., Palazoglu, A., Suresh,
S. and C. Ortiz. Nanoscale Heterogeneity
Promotes Energy Dissipation in Bone, Nature
Materials 6(6), 454-462, 2007. 10. Han, L.,
Dean, D., Mao, P., Ortiz, C. and A. J.
Grodzinsky, Nanoscale Shear Deformation
Mechanisms of Opposing Cartilage Aggrecan
Macromolecules, Biophysical Journal 93(5),
L23-L25, 2007. 11. Ulm, F.-J., Vandamme, M.,
Bobko, C., Ortega, J. A., Tai, K. and C. Ortiz,
Statistical Indentation Techniques for Hydrated
Nanocomposites Concrete, Bone and Shale,
Invited review article, Journal of the American
Ceramic Society 90(9), 2677-2692, 2007.
OUTGROWTH OF STUDENT SUPERVISED RESEARCH
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PUBLICATIONS IN REFEREED JOURNALS OF CHRISTINE
ORTIZSINCE TENURE (16)
12. Arslan, M., Boyce, M.C, Qi, H. J. and C.
Ortiz, Constitutive Modeling of the
Stress-Stretch Behavior of Two-Dimensional
Triangulated Macromolecular Networks Containing
Folded Domains, Journal of Applied Mechanics
75(1), 011020, 2008. 13. Ortiz, C. and M. C.
Boyce, Bioinspired Structural Materials,
Science 319(5866), 1053-1054, 2008. 14. Tai, K.,
Pelled, G., Sheyn, D., Bershteyn, A., Han, L.,
Kallai, I., Zilberman, Y., Ortiz, C. and D.
Gazit, Nanobiomechanics of Repair Bone
Regenerated by Genetically Modified Mesenchymal
Stem Cells, Tissue Engineering Part A 14(10),
1709-1720, 2008. 15. Han, L., Dean, D.,
Daher, L. A., Grodzinsky, A. J. and C. Ortiz,
Cartilage Aggrecan Can Undergo Self-Adhesion,
Biophysical Journal 95(10), 4862-4870, 2008.
OUTGROWTH OF STUDENT SUPERVISED RESEARCH
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PUBLICATIONS IN REFEREED JOURNALS OF CHRISTINE
ORTIZSINCE TENURE (16)
16. Bruet, B. J. F. Song, J. Boyce, M. C.
Ortiz, C., Materials design principles of
ancient fish armor, Nature Materials, 7(9),
748-756, 2008 (Cover of Issue) (Featured in
Fishing for Compliance, commentary by K.D.
Jandt, Nature Materials, 7(9), 692-693, 2008).
OUTGROWTH OF STUDENT SUPERVISED RESEARCH
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PUBLICATIONS OF CHRISTINE ORTIZ
Total number of peer-reviewed publications while
at MIT (70) Post Tenure (29)
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PUBLICATIONS OF CHRISTINE ORTIZ BREAKDOWN BY
JOURNAL (20 Different Journals)
? Biomaterials (1) ? Biophysical Journal (3) ?
Journal of Applied Mechanics (1) ? Journal of the
American Ceramic Society (1) ? Journal of
Biomechanics (5) ? Journal of Biomedical Research
A (1) ? Journal of Engineering Materials and
Technology (1) ? Journal of Materials Research
(2) ? Journal of Materials Science Materials in
Medicine (1) ? Journal of Structural Biology
(Cover) (1) ? Key Engineering Materials (1) ?
Langmuir (4) ? Macromolecular Symposia (1) ?
Macromolecules (6) ? Nano Letters (1) ? Nature
Materials (2) ? Physical Review Letters (1) ?
Soft Matter (1) ? Science (1) ? Tissue
Engineering (1)
Post-Tenure In Blue Text
? Conference Proceedings ORS Transactions, MRS
Proceedings, ACS Polymer Preprints (25)
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SELECTED RECENT RESEARCH INVITED TALKS OF
CHRISTINE ORTIZ (SINCE TENURE) ? August 2006,
Gordon Research Conference on Biomineralization,
New London, NH. ? December 2006, , August 2007,
January 2008, Weapons and Materials Research
Directorate of the Army Research Lab, Aberdeen
Proving Ground, MD. ? March 2007, The American
Physical Society March Meeting, Denver, CO. ?
December 2007, Dow Distinguished Lecture, UCSB ?
January 2008, Yale University, New Haven, CT ?
January 2008, 2008 Annual International symposium
"Frontiers of Nanotechnology and Biotechnology
Integration and Invention," Hunter College of
City University of New York, New York, NY. ?
February 2008, The Technion, Israel Institute of
Technology, The Shraga Dirnfeld Lecture,
Department of Materials Science and Engineering,
Haifa, Israel. ? March 2008, Weizmann Institute
of Science, Rehovot, Israel. ? March 2008, Hebrew
University of Jerusalem, Hadassah Medical Center,
Jerusalem, Israel. ? November 2008, Materials
Research Society Fall Meeting, Boston, MA. ?
January 2009, Society for Integrative and
Comparative Biology, Boston, MA. ? March 2009,
Institute for Defense Analysis, Washington,
DC. 100 invited lectures, gt20 international in
12 countries, 8 different Gordon Research
Conferences since coming to MIT
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RECENT HONORS (SINCE TENURE) OF CHRISTINE ORTIZ
The Dow Distinguished Lecturer,
2007 University of California, Santa
Barbara Lady Davis Fellow, Hebrew University of
Jerusalem (Israel) 2008 Hebrew University
Hadassah Appreciation Medal 2008 (Jerusalem,
Israel) The Shraga Dirnfeld Lecture, Technion -
Israel Institute of 2008 Technology (Haifa,
Israel) Defense Science Study
Group 2008-2009 Study Group (DSSG) National
Security Science and Engineering Faculty
2008-2013 Fellow (NSSEFF) Martin Luther King,
Jr. Leadership Award, MIT 2009
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RESEARCH CONTRACTS GRANTS FOR CHRISTINE ORTIZ
only for C. Ortiz (excluding other PIs/co-PIs)
TOTAL GUARANTEED PROJECTED FUNDING 7.62M (5.3M after tenure) MISTI Israel (1.72M)
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TEACHING EVALUATION DATA FOR CHRISTINE ORTIZ
(SINCE TENURE)
Instructors Evaluation
Course Evaluation
ST06 3.052 5 5 CEG 7.0 6.3
FT06 (co- taught) 3.032 35 26 CEG 6.3 5.6
FT06 (co- taught) 3.034 37 28 CEG 6.2 5.3
ST07 3.052 34 29 CEG 6.4 5.7
AVERAGE (SINCE TENURE) 6.4 5.7
Sabbatical 2008
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CURRENT MIT SERVICE OF CHRISTINE ORTIZ
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SELECTED PROFESSIONAL SERVICE (SINCE TENURE) OF
CHRISTINE ORTIZ
? Advisory Board Panelist, NSF-CAREER Committee
of Visitors Review (Oct. 2006) ? Proposal
Reviewer and Panelist, NSF-CAREER Biomaterials
(Oct. 2006) ? Session Chair, 2007 American
Physical Society Annual Meeting, Session U4
Interfaces with Synthetic and Biological
Polymers, Division of Polymer Physics at the
(Denver, CO, March 2007) ? Organizer, Short
Course at the 2007 American Physical Society
Annual Meeting on "Advances in the Use of Atomic
Force Microscopy for Studies of the Physics of
Macromolecular Materials" (Denver, CO, March
2007) ? Invited panelist Workshop on
Interdisciplinary, Globally Leading Polymer
Science and Engineering an NSF Workshop
co-sponsored by AFOSR, ARO, DOE/BES, NASA,
NIH/NIBIB, NIST, and ONR (Sept. 2007) ? Proposal
Reviewer and Panelist, NSF-CAREER Division of
Materials Research (Oct, 2007) ? Proposal Review
and Panelits, NSF-MDSE Materials Design and
Surface Engineering (Jan. 2008) ? Co-organizer,
Symposium on Functional Biointerfaces, European
Materials Research Society (E-MRS) (March
2009-May 2010) (Strasbourg, France) ? Board of
Directors, Technion-MIT Hibur Program (Haifa,
Israel, May 2009-present) ? Editorial Board,
for the journal International Journal of Surface
Science and Engineering, published by
Inderscience Publishers (Sept. 2005 Present)
? Coeditor for the journal Biointerphases,
published by the American Vacuum Society and the
American Institute of Physics (Nov. 2005
Present ) ? Editorial Board, for the journal
Advanced Biomaterials by WILEY-VCH GmbH Co KGaA
Oct. 2008-present
Editorial Service
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American Physical Society - Division of Polymer
Physics Short Course 2007 Saturday, March 3rd
and Sunday, March 4th, 2007 Denver,
Colorado Advances in the Use of Atomic Force
Microscopy for Studies of the Physics of
Macromolecular Materials (http//www.aps.org/meeti
ngs/march/special/dpoly.cfm)
Lateral force microscopy Piezoresponse force
microscopy Small scale nanoindentation Integration
with optical /chemical characterization
Combinatorial nanomechanics Stimulus responsive
polymer brushes
Instrumentation and New Methodologies Hansma
Kalinin Bonilla Attard Lewis
Whole Tissues Cells Hansma Van Vliet Han
(Ortiz) Stolz
Synthetic Polymers / Nanopatterning Van Vliet
Zauscher
Single Molecules Hansma Ortiz Zauscher
Engineered cells and tissues Stem cells Knock out
mice Diagnostics
Sacrificial bonds Single molecule imaging and
force spectroscopy
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SELECTED OUTREACH OF CHRISTINE ORTIZ (SINCE
TENURE) Guest Speaker, Museum of Science Current
Science and Oct. 2007 Technology Stage
Advisory board for development of
daily animated childrens Jan. 2008 PBS
Television series and multimedia project Wild
Kratts, involving the use of animals to explain
fundamental science concepts to children ages
6-10 years old (Montreal, CA)
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SELECTED DIVERSITY ACTIVITIES OF CHRISTINE ORTIZ
(SINCE TENURE)
? Invited Speaker, Minority Summer Research
Program (MSRP, Aug. 2006) Invited Speaker,
Minority Introduction to Engineering Science
(MITE2S) Program (MSRP) Aug. 2006 ? Faculty
Advisory Board to the Office of Minority
Education (Sept. 2006 Dec. 2007) ? Graduate
Student Recruitment, The Society for
Advancementof Chicanos and Native Americans in
Science (SACNAS), Tampa, FL (Dept. Institute,
Oct. 2006, Oct. 2007) ? Diversity Initiative
Committee (Reporting to the Provost, March 2007
Present)
? Admissions, Minority Introduction to
Engineering Science (MITE2S) Program (March 2007,
March 2008) ? Invited Participant, MIT9
Conference Attendee Focusing on Diversity
(Washington, DC, Institute) April 2007 ? Invited
Speaker, Campus Preview Weekend,
Underrepresented  Minority Parents   April 2007 ?
Invited Speaker (Research Presentation), Minority
Introduction to Engineering Science (MITE2S)
Program (MSRP) Aug. 2007 ? Invited Panelist,
Workshop on Achieving Racial Ethnic Equity in
Chemistry sponsored by National Science
Foundation (NSF) / Department of Energy (DOE) /
National Institutes of Health (NIH) (Arlington,
VA, Sept. 2007 ? Invited Banquet Speaker,
CONVERGE (graduate preview weekend for
underrepresented minority Invited Moderator,
Institute-wide Round Table Discussion,
Facilitating a Path to and Through Graduate
School for Underrepresented Minorities, UCSB
Nov. 2007