Botanical Research Centers: NIEHS Interests - PowerPoint PPT Presentation

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Botanical Research Centers: NIEHS Interests

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Botanical Research Centers: NIEHS Interests Elizabeth A. Maull, Ph.D. Program Administrator, NIEHS – PowerPoint PPT presentation

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Title: Botanical Research Centers: NIEHS Interests


1
Botanical Research CentersNIEHS Interests
  • Elizabeth A. Maull, Ph.D.
  • Program Administrator, NIEHS

2
Historical
  • 1998 National Toxicology Program held a
    Workshop on Herbal Medicines
  • Recommendations
  • More research on herbals
  • A call for industry to identify and standardize
    product ingredients
  • Increase consumer education

3
National Toxicology Program Efforts
  • Herbs and active or toxic ingredients of herbs
    nominated and selected for study by NTP
  • Criteria widespread human exposure
  • Assessments preformed by NTP
  • Acute high dose effects
  • Chronic low dose effects
  • Reproductive toxicity
  • Neurotoxicity
  • Immunotoxicity

4
National Toxicology Program Efforts (cont.)
  • Of special interest to the NTP
  • Potential for herb/herb or herb/drug interactions
  • Responses of sensitive subpopulations
  • Pregnant women
  • Developing fetus
  • Young
  • Elderly

5
NIEHS Focus for BRC Recompetition
  • Centers structured around a central scientific
    theme
  • Research projects that complement ongoing
    National Toxicology Program efforts

6
NIEHS Focus for BRC Recompetition
  • Agriculturally related issues
  • Biologically related issues

7
Agriculturally Related Issues
  • Identification of environmental factors
    influencing the concentration of bioactive
    constituents
  • Localization of bioactive ingredients within the
    plant
  • Development of fingerprinting technologies
  • Identify the plant source of a botanical
  • Detection of adulterations of botanicals

8
Biologically Related Issues
  • Mechanisms of action of bioactive ingredients
  • Identification of targets for botanicals
    (molecular, cellular, organ)
  • Identification of interactions (antagonistic or
    synergistic) with other botanical components
  • Potential botanical/botanical or botanical/drug
    interactions

9
Biologically Related Issues (cont.)
  • Pharmacokinetic / pharmacodynamic analyses of
    botanicals
  • Study the role of botanicals as regulators of
    genetic pathways or epigenetic events
  • Identify and validate biomarkers of botanical
    intake or biological effects

10
Botanicals of Interest (NTP)http//ntp-server.nie
hs.nih.gov/htdocs/liason/factsheets/HerbMedFacts.p
df
  • Aloe vera gel
  • Black cohosh
  • Bladderwrack
  • Blue green algae extract
  • Comfrey
  • Echinacea purpurea Ephedra
  • Ginkgo biloba extract
  • Ginseng and ginsenosides
  • Goldenseal
  • Green tea extract
  • Kava kava extract
  • Milk thistle extract
  • Pulegone
  • Senna
  • Thujone

11
Elizabeth A. Maull, Ph.D. Program
Administrator Susceptibility and Population
Health Branch National Institute of Environmental
Health Sciences T (919) 316-4668 F (919)
316-4606 E maull_at_niehs.nih.gov
 
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