Title: Botanical Research Centers: NIEHS Interests
1Botanical Research CentersNIEHS Interests
- Elizabeth A. Maull, Ph.D.
- Program Administrator, NIEHS
2Historical
- 1998 National Toxicology Program held a
Workshop on Herbal Medicines - Recommendations
- More research on herbals
- A call for industry to identify and standardize
product ingredients - Increase consumer education
3National Toxicology Program Efforts
- Herbs and active or toxic ingredients of herbs
nominated and selected for study by NTP - Criteria widespread human exposure
- Assessments preformed by NTP
- Acute high dose effects
- Chronic low dose effects
- Reproductive toxicity
- Neurotoxicity
- Immunotoxicity
4National Toxicology Program Efforts (cont.)
- Of special interest to the NTP
- Potential for herb/herb or herb/drug interactions
- Responses of sensitive subpopulations
- Pregnant women
- Developing fetus
- Young
- Elderly
5NIEHS Focus for BRC Recompetition
- Centers structured around a central scientific
theme - Research projects that complement ongoing
National Toxicology Program efforts
6NIEHS Focus for BRC Recompetition
- Agriculturally related issues
- Biologically related issues
7Agriculturally Related Issues
- Identification of environmental factors
influencing the concentration of bioactive
constituents - Localization of bioactive ingredients within the
plant - Development of fingerprinting technologies
- Identify the plant source of a botanical
- Detection of adulterations of botanicals
8Biologically Related Issues
- Mechanisms of action of bioactive ingredients
- Identification of targets for botanicals
(molecular, cellular, organ) - Identification of interactions (antagonistic or
synergistic) with other botanical components - Potential botanical/botanical or botanical/drug
interactions
9Biologically Related Issues (cont.)
- Pharmacokinetic / pharmacodynamic analyses of
botanicals - Study the role of botanicals as regulators of
genetic pathways or epigenetic events - Identify and validate biomarkers of botanical
intake or biological effects
10Botanicals of Interest (NTP)http//ntp-server.nie
hs.nih.gov/htdocs/liason/factsheets/HerbMedFacts.p
df
- Aloe vera gel
- Black cohosh
- Bladderwrack
- Blue green algae extract
- Comfrey
- Echinacea purpurea Ephedra
- Ginkgo biloba extract
- Ginseng and ginsenosides
- Goldenseal
- Green tea extract
- Kava kava extract
- Milk thistle extract
- Pulegone
- Senna
- Thujone
11Elizabeth A. Maull, Ph.D. Program
Administrator Susceptibility and Population
Health Branch National Institute of Environmental
Health Sciences T (919) 316-4668 F (919)
316-4606 E maull_at_niehs.nih.gov