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????,RN.,%20PHN

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Title: ????,RN.,%20PHN


1
?????(????????)??????????????
  • ??????????
  • ?????????????????????
  • ????,RN., PHN

2
?????????(????????)
  • ????????(CML)????
  • CML??
  • ????
  • ????????????????????????????????
  • 50????????????????????
  • 10???12????

http//www.medic.mie-u.ac.jp/pathol_matrix/RESOURS
E/photos/aplastic_anemia/2.html
??(?)???? ???? ??? ????
3
?????(????????) 1
  • ???????(????????????????????????????)?????????????
    ??????????
  • ??????????????5????????????????
  • ??????????????????????????????????????????????????
    ?????????50???????

50
Nature Medicine 15, 1149 - 1152 (2009)
4
?????(????????) 2
  • Brian Druker??????
  • 2009? ??????????????????
  • ????2009???????????????????????????
  • -????????????-
  • Ph???????????????CML???????????bcr/abl???????????
    ?????????1990??????bcr/abl???????????????????????
    ????
  • ??????
  • 1998? ????????
  • 2001?12?????(????????)

Nature Medicine 15, 1149 - 1152 (2009)
5
?????(??????)??????
  • ????????????
  • ??????! ???! ?????!!1)??????????
    ????????????????????? ??????????????????
  • 2)??? ???????????? ?????????????????????? ??????
    ?

6
?????????????!!????????????????????? 1
  • ?????? ????
  • ????????????ZERO?????
  • ???????????????
  • ??????????????????????????????????
  • ?????????????????????????????????

7
?????????????!!????????????????????? 2
  • ????? ???????????????
  • ???????????????
  • ????????
  • 1? 3128.5?(2010?3???)
  • 1?4??????????? ?1? 12,514?1??
    3128.5(/1?)4?30?375,420
  • (????????? ?11??)
  • ??????? 12120??
  • ??????????????????????????

8
????? ????????
????????????Pt Support
  • ????8?????????????566?(??? 1200)
  • ???????????????????485?????????????144??(?????46?
    ???)?????????????????
  • ??????
  • ? 367 ? 197(????2?)
  • ????? 61?(15-94)
  • CML??????? 54?(2-88)

9
  • ????????????????
  • 412?/566(73)
  • ???????????????????
  • ????????????????????? ????????????????...
  • 211?/566(37 )
  • ???????????????????????????
  • 17?(3)(??????2?)

10
CML???????????
??12? 17? 20?
??(???) 533(?) 400.5(?) 389(?)
??? 100(?) 129(?) 122(?)
???
?????????
??20?????????????? http//www.mhlw.go.jp/toukei/s
aikin/hw/k-tyosa/k-tyosa08/index.html
11
?????????????????
??????????????? ??????10
????????????????????????????????? ????????????????
????????????????????? ?????????????????
???? 53
??? 44
????? 44
?? 41
?? 38
???? 35
?? 31
??? 25
????? 24
??? 15
???? 12
?? 8
??? 24
CML???? ????????????
?????? 30(95????) 5? (80????)
???? 5?(70????) 2(???????)
???????? 15 15
??????????? 50 ?30
12
??????????!
????????????????????????
  • ???????????
  • ??????????????????????
  • ?????????????????

????????????????? ??????????????????
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