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1 ??????Qa?

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Title: 1 ??????Qa?


1
???????????
  • ??????????

2
???? ????
  • 1 ??????Qa?
  • 1.1 ????????
  • ?????????
  • ????????????????????????,??12?????

3
1.1 ????????
  • 1.1.1 ???????
  • ?????????(????)
  • 1.1.2 ?????
  • ??????(????)
  • 1.1.3 ????
  • ?????????(????)
  • 1.1.4 ????
  • ????????????(????)

4
1.1 ????????
  • 1.1.5 ????
  • ????
  • ????
  • ????
  • ?????(Prescribing Information)
  • ????(Monography)
  • ?????
  • ????
  • ??????(MSDS)(????)

5
1.1 ????????
  • 1.1.6 ????
  • ??????????????(????)
  • 1.1.7 ????
  • ?????????(????)
  • 1.1.8 ????
  • ???????????(????)
  • 1.1.9 ??
  • ???????????(????)

6
1.1 ????????
  • 1.1.10 ??
  • ???????????(????)
  • 1.1.11 ??
  • ????????????????(????)
  • 1.1.12 ????????
  • ???? ? ???? ? ????
  • ???????????????????????12?????????,???
    ?????????

7
1.2 ???????????
  • 1.2.1 ??????
  • 1.2.2 ??????
  • ?????????????????????,????????????????

8
1.3 ???????????
???????????????,????,?????
9
2 ????????
  • ????(Ghemical Name)
  • ????(Trade Name)
  • ????(Generic Name)
  • ???????(International Nonproprietary Name, INN)
  • ????????
  • ????
  • CAS???

10
2.1 ????(Chemical Name)
  • Common Name
  • p-isobutyl-hydratropic acid
  • ?-????????
  • Systemic Name(IUPAC)
  • ()-2-(4-isobutylphenyl)propionic acid
  • ??-2-(4-????)??
  • CAS Name
  • Benzeneacetic acid, a-methyl-4-(2-methylpropyl)
    -
  • a-??-4-(2-????)???

11
2.2 ????(Trade Name)
  • Advil brufen Ibufen Motrin Nuprin
    Nurofen Paduden Proflex Rufin Unipron

12
2.3 ????(Generic Name)
  • USAN(United States Adopted Names)
  • BAN(British Approved Names)
  • JAN(Japanese Accepted Names)
  • NFN(Names Approved by the Nordic Pharmacopoeia
    Council)
  • Ibuprofen

13
2.4 ???????
  • WHO?????????,????????,?????????,???????
    ???
  • (International Nonproprietary Names for
    Pharmaceutical Substances,??INN)?
  • 1953?????????????,??????,????????????,??
    ???????????????????????INN?????INN??????,????,????
    ????

14
2.4 ???????
  • ?WHO??,???????,???????INN???????????,??
    ?????????????,WHO????INN(Proposde
    INN)????,??????,??????????,?????INN
  • (Recommedded INN)????,?????????,??????????????????
    ????????????,??????INN?

15
2.5 ????????
  • ????????(Chinese Approved Drug
    Names,??CADN)?CADN????????????????????????????
  • ???

16
2.6 ????
  • RD-13621
  • U-18573
  • ATC-3

17
2.7 CAS???
  • IUPAC?????
  • CAS??
  • 15687-27-1

18
3 ?????????
  • ????(??????)
  • ????(??????)
  • ????(????)
  • ????(????)
  • ????(???)
  • ????(???)

19
4 ?????????
  • INTERNET (???)
  • WWW(???)
  • HTTP(???????)
  • URL(???????)
  • HTML(???????)
  • WWW Browsers(WWW ???)
  • FTP(??????)
  • E-mail(????)
  • Proxy Cache(????????)

20
4.1 INTERNET (???)
  • INTERNET??????????????,???TCP/IP??????,???????????
    ???????????????????,?????????????????,????????
    ?????
  • ??????????????,??????????????
  • ???????????,???????????????????????????
  • ??????????????????/?????????

21
4.2 WWW(???)
  • WWW?World Wide Web??????World Wide
    Web,???Web????????,?????????,???????????????,W
    WW?????????
  • WWW??????????????????????????????????????????,????
    ????(????????????????????)??????????,?????????????
    ?WWW????????,??????????????
  • ?WWW????,?????????????????????????,?WWW???????????
    ???

22
4.3 HTTP(???????)
  • HTTP?HyperText Transport Protocol
    ????????????????????
  • HTTP????????(WWW)??????????
  • ?????WWW??????????,????????(????)??????????,??????
    ???????????HTTP???????????????,?????????????????
    ???????????

23
4.4 URL(???????)
  • URL? Uniform Resource Locator ???????????????????
    ?
  • URL??Internet??????,??????Internet????????????????
    ?????????????,????Internet????????????
  • URL?????,?????????????????????,????????????(?IP??
    )?????????????
  • ?

24
4.4 URL(???????)
  • ????
  • ../home.htm
  • ???????????????
  • ???? http//lib.hebust.edu.cn/zxtg/001.htm ?
    http//202.206.73.60/zxtg/001.htm
  • URL??????www?????,??????FTP?Gopher?WAIS?Uesnet
    News?Telnet??????????

25
4.5 HTML(???????)
  • HTML ? HyperText Markup Language
    ????????????????????
  • HTML???????????WWW?????????,???????(SGML)???,?????
    ?????????????????????
  • HTML????????????,???WWW??????,????????????,???????
    ?????,?????????????(?Internet Explorer)????

26
4.6 WWW Browsers
  • WWW ???? WWW ??????,???? WWW ?????????????????
  • ????????????? (NCSA) ?1993???? Mosaic ????? WWW
    ???,??? WWW ???????????,??????????????
  • ???????????????????(Netscape Navigator)????????
    ?(Internet Explorer,??IE)?
  • ????? IE ? WINDOWS ???????????? WINDOWS
    ?????,?????? IE?

27
4.7 FTP(??????)
  • FTP ? File Transfer Protocol ???????????????????
  • ????????FTP,?????FTP????????????????Internet?????F
    TP????????????ASCII????????????
  • Anonymous FTP ?????? FTP ????,? Anonymous
    ?????,?????????????,???????????FTP??????

28
4.8 E-mail(????)
  • E-mail ? electronic mail ?????????????????
  • ??????????????????????????????????????????????,???
    ???????FTP??? E-mail Alerts ??????????????????????
    ??????

29
4.9 Proxy Cache
  • ?????????
  • ??????????Proxy Server, ????Proxy ?
  • ??????????
  • ?????????,?????
  • b) ??IP??
  • ???????

30
4.9 Proxy Cache
  • ??????????
  • ?????????????,CERNET????????,??????????????????
  • ??????????IP????????? ?

31
4.9 Proxy Cache
  • ??????????
  • ????????????????
  • ???????BBS????
  • ??????????????
  • ????????????????????????

32
4.9 Proxy Cache
  • ProxyHunter????????????
  • ??????????,???????????????IP????????,????????????
    ??,?????????????????????????????(PROXYHUNTER)????
  • a) ??b) ??c) ??d) ??e) ??f) ??g) ????????

33
5 ???????????
  • ???? (URL's List)
  • ???? (Gate Sites)
  • ???? (Search Engine)
  • ????? (Online Databases)
  • ???? (Online Glossary)
  • ????????

34
5.1 ???? (URL's List)
  • ??/??? (Links)
  • HTML??????????lta href"URL"gt????lt/agt,??,?HTML?????
    ????
  • lta href"http//202.206.73.60/"gt?????????lt/agt
  • ??,?WWW??????,?????????
  • ?????????
  • ?????????????,??????URLs List?
  • ???????????,???????????????URL's
    List,??????????????????????URL's
    List,???????????

35
5.1 ???? (URL's List)
  • ??/????? (Navigation)
  • ???URLs List,?????????????,???????
    ???????,???????,??????????
  • ?????????,??????????,?????????????

36
5.1 ???? (URL's List)
  • ????? (Virtual Libraries)
  • ??????????????????,??????????????????,?
    ?????????????????URL's List,???????????????
  • ????????,?????????????300??????????????
    ????????URL?http//vlib.org/ ????????????????????,
    ?????????

37
5.1 ???? (URL's List)
  • ????? (Virtual Libraries)
  • ????????????????URL???
  • 1)???? http//www.cato.com/biotech/
  • 2)???? http//www.che.ufl.edu/www-che/
  • 3)? ? http//www.liv.ac.uk/Chemistry/Links/
  • 4)? ? http//www.pharmacy.org/

38
5.2 ???? (Gate Sites)
  • ????,?????????????(ISP)???????,?
  • ?? http//www.yahoo.com
  • ?? http//www.sohu.com
  • ?? http//www.sina.com.cn ??
  • ????,??????????????????????,??????????,??????????,
    ???????????????

39
5.2 ???? (Gate Sites)
  • ?????????????????????,???????,????,?????????????,?
    ?????,?????????????????
  • ????????????????????IE???,?????,?????????????,????
    ?????IE??????
  • ??----Internet??----?????

40
5.3 ???? (Search Engine)
  • ??????? ?
  • ?????????
  • ???????
  • ?????????????????
  • ???????
  • ????????????

41
5.3 ???? (Search Engine)
  • ??????? ?
  • ????(Search Engine)????????????????????
    ??????????
  • ????????
  • ?? http//www.sohu.com ?? http//www.sina.com.c
    n
  • ?? http//www.yeah.net ?? http//e.pku.edu.cn
  • Yahoo! http//www.yahoo.com/ Google
    http//www.google.com

42
5.3 ???? (Search Engine)
  • ???????
  • 1)????????????
  • 2)????????????????
  • 3)????????????
  • 4)??????????,???????????
  • 5)??,??????????????????????

43
5.4 ????? (Online Databases)
  • ???????????????????????????????
  • ????????,??????????????????????
  • ???????,???????????????????????
  • ?????????,???????????????????
  • ??????????,?????????????????????

44
5.4 ????? (Online Databases)
  • ??????????????,?????????,??????????
  • ?????????? http//www.nstl.gov.cn/
  • ??????? http//www.sdb.ac.cn
  • ??????????????? http//202.127.145.134

45
5.5 ???? (Online Glossary)
  • ??? 21
    http//www.chemicalland21.com/
  • ??????? http//www.hclrss.de
    mon.co.uk/

46
5.6 ????????
  • ???????? http//www.cnki.net
  • ???????????? http//61.186.190.10380
    80/
  • (????test ??test)

47
6 ??????
  • Internet Explorer (IE)
  • WinRAR
  • Netants
  • Foxmail
  • Acrobat Reader
  • Alterna TIFF
  • ???????
  • Chemoffice

48
6.1 Internet Explorer (IE)
  • Internet Explorer,?????IE,?Microsoft??????? WWW
    ???????????? Internet Explorer,??????? Web
    ???????
  • ????????????Internet Explorer 6.0(?????)??????????
    ??????IE?????,???????windowsupdate.microsoft.com??
    ?????
  • Internet Explorer??????????,???,????????????????
    ??????

49
6.2 WinRAR
  • WinRAR ????
  • WinRAR?32? Windows ??? RAR ????????
  • WinRAR ??
  • 1)???? RAR ? ZIP ????
  • 2)??????? (??????)
  • ????http//www.winrar.com.cn/

50
6.3 Netants
  • NetAnts???????,????,??????????????????,??????
    ??????? ?
  • ????????????NetAnts 1.25(?????)????????????????Net
    Ants?????,???
  • http//www.netants.com???????
  • ?????????,???????????

51
6.4 Foxmail
  • Foxmail ???????????????,????? Internet ???????
  • ?????????????WebMail??(??????)????????????????????
    ?,?????????????,????????????????????????????????,
    ?????????????????????????????????????,????????????
    ??????????????
  • ???? http//www.foxmail.
    com.cn

52
6.5 Acrobat Reader
  • Acrobat Reader ?Adobe????????????,??????PDF?????
  • ?????????,??????????????????,????????,???PDF??????
    ??,??????????????? Acrobat Reader
    ??,?????PDF???????????????
  • ?Acrobat PDFWriter??????????????PDF????????PDF???
    ?????

53
6.6 Alterna TIFF
  • ????????????????????????????????,????????TIFF?????
    ??,????????????? Alterna TIFF ??,?????TIFF????????
    ???????
  • TIFF????????
  • http//www.alternatiff.com/install/

54
6.7 ???????
  • ????????????,??????????,????????????????,???????
    ?,????????????,???????????
  • ??,????????????????,?????????CAJ???,????????????
    ??,?????????NLC???......?

55
6.8 Chemoffice
  • ChemOffice Ultra 2004???
  • ChemDraw Ultra 8.0??????
  • Chem3D Ultra 8.0???????
  • ChemFinder Pro 8.0??????????
  • ???????????Chemoffice Ultra 8.03
  • Serial 7654321
  • key VLPG-CG5O-5K22-VKVK-RF

56
???? ????
  • 7 ?????????
  • 7.1 ?????????????
  • 7.2 ???? (Online Glossary)???

57
7.1 ??????????
  • CRC ???????http//www.hbcpnetbase.com/ (?????7?)
  • Kirk-Othmer ??????http//www.mrw.interscience.wil
    ey.com/kirk/ (???????)
  • HPLC??????http//hplc.chem.shu.edu/NEW/HPLC_Book/
    index.html
  • NMR??????http//www.cis.rit.edu/htbooks/nmr/
  • National Academy Press,Read Books Online Free
    http//www.nap.edu/about/availpdf.phtml
  • 500????????????http//fb4d.com/
  • ????????????http//www.amedeo.com/

58
7.2 ???? (Online Glossary)
  • ??? 21 http//www.chemicalland21.com/
  • ?????????,????????,?????????????????,??
    ??????PRODUCT IDENTIFICATION?PHYSICAL AND
    CHEMICAL PROPERTIES?GENERAL DESCRIPTION
    APPLICATIONS?SALES SPECIFICATION?TRANSPORTATION?OT
    HER INFORMATION?,?????????????????????????????????
    ?

59
7.2 ???? (Online Glossary)
  • ??????? http//www.hclrss.demon.co.uk/
  • ???????,?????????URL? http//www.alanwood
    .net/pesticides/
  • ??32????1400?????????????????????ISO????
    ??????ISO??????????,2-3???????????

60
7.3 ?????????
  • ???????????
  • ??http//www.cnki.net???????
  • ????????????
  • ????????
  • ?http//www.google.com ????????????????
  • Keywords pyruvate, comprehensive, review

61
8 ??????
  • 8.1 ????????
  • 8.2 ????????
  • 8.3 ?????EPO?????????
  • 8.4 ????????WIPO?????????
  • 8.5 ?????JPO?????????(???)

62
8.1 ????????
  • ?????????????? http//www.sipo.gov.cn/sipo
    /zljs/default.htm
  • ????TIF????,????????????,????????
    ??????????????(http//www.alternatiff.com/install/
    )
  • ?????????
  • ?????????TIF????????

63
???????16?????,????
64
8.2 ????????????
  • ???????USPTO????????? http//www.uspto.gov/patf
    t/index.html
  • Issued Patents (PatFT) 1790??????????????????????
    ,??,1976????????????????
  • Published Applications (AppFT) 2001?3?15???????(?
    ??)??????????????,??????????(??)???

65
8.2 ????????????
  • Quick Search??????????????????
  • Advanced Search?????????????????????
  • Patent Number Search???????,????????????

66
8.2 ????????????
  • ????????????????????????????????Search
  • 1976 to present full text
  • 1790 to present entiredatabase
  • 1790 to 1975 PN and CCL only
  • Patents from 1790 through 1975 are searchable
    only by Patent Number and Current US
    Classification!

67
8.2 ????????????
  • ?Query ??????????????????????Search
  • ?????????
  • TTL/(glyoxylic AND (production OR preparation OR
    manufacture) ANDNOT (derivatives OR ester OR
    esters))

68
8.2 ????????????
  • ?????????

69
8.2 ????????????
  • ???????(??)

??? ??? ??? ???
PN ??? CCL ???????
ISD ??? ICL ???????
TTL ???? APN ?????
ABST ?? APD ???
ACLM ???? IN ???
SPEC ???? AN ???
70
8.2 ?????????????
  • ?Query??????,???
  • 1)???????????
  • 2)????????
  • 3)????????
  • ?????2?????
  • 1)1975????????
  • 2)1976?????????

71
8.2 ?????????????
  • ?????(Full text)?????????????????,??????????,????
    HTML??????????????????????????,?????????????????
    ?????????
  • ???????????????,???????????Images???????full
    text?Images????????????????TIF?????(??????????????
    ??)?

72
8.3 ????????????
  • ?????URLhttp//ep.espacenet.com/
  • ??19????????????????,?????????????(???)??,????????
    ????????
  • ?????????????,URL???????????????,?
  • ?? gb?? fr??? es???? cy?? ch
    ????????????????????,???????
  • ?Acrobat Reader???????????

73
8.3 ????????????
  • ??4???????????
  • Quick Search ??????????????
  • Advanced Search???????????????,????????????
  • Number Search???????????????????????????
  • Classification Search????????????

74
8.4 WIPO?????????
  • ?????URLhttp//www.wipo.int/
  • ??1997?1????????PCT???????????
  • 1997?1?????????????????????????worldwide?????
  • ??????,????,???????????
  • ????????(??)?????????????,???????14????????

75
8.5 JPO???????(???)
  • ?????URLhttp//www.ipdl.jpo.go.jp/homepg_e.ipdl
  • ??1976?10???????????????(?????????)?????
  • ??1993???????????????????

76
9 ????????????
  • 9.1 ?????????????
  • 9.2 ???????????
  • 9.3 ???????????

77
9.1 ?????????????
  • ?? http//www.nstl.gov.cn
  • ???????17,824,313?,??
  • ?????????? (503135?)??????? (592084?)?????
    (6238189?)??????? (21187?)???????? (1708?)
  • ?????????? (2355829?) ????? (6879242?)???????
    (784184?)??????? (74335?)????? (109216?)
  • ??????????? (183136?)????? (82068?)

78
9.1 ?????????????
  • ????
  • ?????????????????????????????????(??????
    ????)??????????????????
  • ????,????????
  • http//www.nstl.gov.cn

79
9.2 ????????
  • ?? http//www.cnki.net
  • ??
  • ???????????CNKI??????????152?,??????,??
    ??????????
  • ??
  • ?????????????????
  • ???????????????,????????,??????,?????
    ??????
  • ?????????????????????????????????
    ????????????) ?????????????????

80
9.3 ???????????
  • ChemWeb.com Quick Abstract Search
    http//www.chemweb.com/abstracts/
  • ??Elsevier?Kluwer?Marcel
    Dekker?????????????310?,?????,??????
  • National Library of Medicines Medline and
    Premedline Databases
  • http//www.medportal.com/

81
9.3 ???????????
  • 1400????????? http//www.freemedicaljournals.com
  • ???????? http//www.pubmedcentral.nih.gov/about/b
    mcjournals.html
  • ????,??????????????????????????????????
    ?????,???????????????,??????????????????????????,?
    ???????????

82
10 ??????????
  • ??????????????? http//202.127.145.134
  • ???????????,????????????

83
10.1 ????????
  • ????????http//202.127.145.134/ssdb/str/str_full_q
    uery.asp
  • ??????????????????????????????????
  • ?????????
  • http//202.127.145.134/ssdb/str/str_pro_query.
    asp
  • ????????????CA??????????????????????????
    ?

84
10.2 ?????????
  • ???????? http//202.127.145.134/ssdb/crc/str_full
    _query.asp
  • ???????????????????
  • ????????
  • http//202.127.145.134/ssdb/crc/crc_query.asp
  • ???????,????????

85
10.3 ?????????
  • 1) ???????
  • http//202.127.145.134/ssdb/irs/irs_p
    ro_query.asp
  • ?????????????CA???????????
  • 2) ????
  • http//202.127.145.134/ssdb/irs/ir_upl
    oad.asp
  • ???????????(prn,asc??)?????????????nyy
    ??,?????????????????????

86
10.4 ????XIV???????
  • ??-??????
  • http//jpdb.nihs.go.jp/jp14e/ultraviolet_spect
    ra.html
  • ??????
  • http//jpdb.nihs.go.jp/jp14e/infrared_spectra.
    html

87
11 ???????????
  • 11.1 ????
  • ???????? http//www.qualityinfo.com.cn/GN.asp
  • ??????(?????????????)?????(???????????
    ????ISO??)???????????????????
  • 11.2 ??????(MSDS)??
  • MSDS Databases http//www.msdssearch.com/DB
    LinksN.htm

88
12 ????
  • ????????????
  • http//ccn.mofcom.gov.cn/
  • ?????????? http//www.chemol.com.cn/linktoywlk/pc
    hinasearch.asp
  • ????????? http//www.chemsina.com8768/pecbusines
    s/defaultshow.asp
  • ????????? http//www.chemsina.com8768/dailynews/
    c/defaultshow.asp
  • ????????
  • http//www.wanfangdata.com.cn/

89
13 Merck Index ?????
  • 12.1 Merck Index 13th
  • http//themerckindex.cambridgesoft.com
    /
  • ???????,?????14??
  • 12.2 ?ChemFinder?Merck Index???????
  • http//chemfinder.cambridgesoft.com/

90
14 ??????
  • ?????google?????,
  • ? Pyruvate fy ? search, ????
  • pyruvate ????
  • ? pyruvate review comprehensive
    ????????,???????PYRUVATE A COMPREHENSIVE
    REVIEW(C)1997??13?????????????

91
14 ??????
  • ? pyruvate pdf MSDS ????????,??Sodium Pyruvate
    Solution ?PDF???MSDS???
  • ? biochemistry ppt ????????,??????????????????
  • ? Roche annual report????????,??????1999-2004?????
    ??

92
???google???????1?
  • ?vitamin b12 and HPLC and fermentation??????,??w
    ww.nstl.gov.cn/?????????,?????????????Determinati
    on of vitamin B12 in multivitamin tablets and
    fermentation medium by high-performance liquid
    chromatography with fluorescence detection.
    Journal of Chromatography.891(2),243-247(2000)

93
???google???????1?
  • ???????????,??www.google.com??????,??????????,????
    ??????????web.hku.hk/sfchen/????????56??????????
    ?E-mail??sfchen_at_hkusua.hku.hk

94
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