Interactive Web-Based Probiotics Database for Healthcare Professionals

1
Interactive Web-Based Probiotics Database for
Healthcare Professionals Colleen Conlon BS, BA,
MS, Nicole Andreini BS, Ariel Mooney RDH, BS,
Rishi Ramraj BS, John G. Thomas MS, Ph.D.
Oral - 75 Articles - Candida albicans - Dental
plaque - Gingivitis - Perio pathogens - Strep.
mutans - Halitosis
Neurological- 1 Article - Brain activity
Results (cont.)
Introduction
Endocrine 12 Articles - Diabetes -
Gestational diabetes
The World Health Organization reported that 30
of the global population consumes 87.5 billion
worth of pre/probiotics a year3,4. Recent
advances in metagenomics have fostered greater
clarity of human microbiota and the use of
probiotics into two interactive/complimentary
pathways bioburden reduction and immune
up-regulation/modulation3,4. Problem
Considerable confusion and misunderstanding
exists about the value of probiotic therapy,
fostered by a plethora of commercial products
availability without prescriptions. This has
caused a lack of uniformity in the use,
regulation, and study of probiotics1,2. Hypothes
is Studies indicate that probiotics are
successful in managing a large range of diseases
including infections of the gastrointestinal,
urinary, integumentary, endocrine, and immune
systems.
Greatest dental clinical focus included caries,
periodontal disease, halitosis, and Candida
infection, with a growing application in
nurseries and daycare centers. A computer
database was constructed providing educational
materials for both consumer and health providers.
The algorithm-based integrated analysis matched
clinical disease, conditions, strength of
evidence, microbes, and probiotics highlighted by
literature and survey reviews. Probiotic
summaries were constructed based on observations
in the literature search.
Immune 35 Articles - Immune regulation -
Allergies - Allergic Rhinitis - Wound Therapy
Cardiovascular- 25 Articles - Obesity -
Cholesterol
Breast 2 Article - Infectious Mastitis
Respiratory 3 Articles - Cystic Fibrosis  -
Ventilator Pneumonia  - Common Cold 
Figure 1. Treatment of periodontal inflammation
with probiotic gum.
Conclusion
In view of CDCs recent proclamation of the Post
Antibiotic Era, probiotics and reconstructive
microbiology are emerging from adjunctive therapy
to real time intervention3. The emergence of
oral metagenomics has catalyzed awareness of
disease management via recreating a balanced
eco-system for restorative microbiology,
particularly in the fields of gastroenterology
and dentistry3,4. Our interactive database,
remaining current with reviews, comments, and
federal guidelines, was constructed to meet the
obvious void in both the consumer and
professional knowledge emphasized by multiple,
international probiotic surveys.
Probiotics/symbiotic and prebiotics are a
growing focus of molecular research with the
development of designer probiotics and
bacterioreplacement therapy, focusing more
recently on immune up regulation and
modulation3,4. We anticipate expansion of
probiotic oral health to include endodontics and
chronic wounds, given the shared pathogenicity
via MMPs, recognizing that toothless
periodontal pockets are now considered
wounds3,4. We are actively searching for grant
support to build the Bac2Health site that is
integrated with industrial, Biotech, state,
international, and federal opportunities.
Methods
A survey was given to dental patients and oral
health care providers over the course of 3 years
to construct a baseline of probiotic knowledge
and use in the oral health field. The most
recent survey is on our website Bac2Health
survey. Over 300 articles were selected and
rated based on the type and validity of the
research. Each paper was ranked on a Strength of
Article grading scale based on the type of study
performed, indicating if there was statistical
significance or lack of benefit found. Each paper
was then coded to correlate conditions with
microbes and probiotic product. A grading system
of A-F was assigned to each probiotic and
bacterium based on the strength of supporting
research found for each condition. A website was
constructed by Rishi Ramraj, using the Remind
platform. The Bac2Health website was created
utilizing the compiled research to allow users to
search for information in several fields such as
probiotic, microbe, disease, and strength of
evidence.
Gastrointestinal 110 Articles - Antibiotic
Associated Diarrhea - Acute Gastritis  -
Blastocytis hominis - Candida Colonization -
Colon Cancer   - Celiac  - Clostridium
difficle  - Crohns Disease  - Constipation  -
Diarrhea  - Helicobacter pylori - IBS - Liver
Disease  - Neonatal Enterocolitis  -
Pouchitis  - Regulation of microflora 
Skin 15 Articles - Eczema - Atopic dermatitis
Results
Surveys confirmed confusion and limited knowledge
of use, benefits, and availability of probiotics
both by consumer and professional health care
providers. There was a significant reservoir of
peer reviewed published literature, mostly
international, that described the use, mechanism
of action, and application of probiotics with
lack of uniformity.
References
Female reproduction 20 Articles - Bacterial
Vaginosis - Vaginal Health - Yeast infection
1. Danielle Wolvers, Jean-Michel Antoine,
Eveliina Myllyluoma, Juergen Schrezenmeir, Hania
Szajewska, and Ger T Rijkers. Guidance for
Substantiating the Evidence for Beneficial
Effects of Probiotics Prevention and Management
of Infections by Probiotics. The Journal of
Nutrition 140, No. 3 (March 2010) 698S 712S.
doi10.3945/jn.109.113753 2. M.F. Zarco, T.J.
Vess, G.S. Ginsburg. The oral microbiome in
health and disease and the potential impact on
personalized dental medicine. Oral Diseases
(2012) 18, 109 120. doi10.1111/j.1601-0825.2011.
01851.x 3. Harpreet Singh Grover, Shailly
Luthra. 'Probiotics the nano soldiers of oral
health. JIACM 2011 13(1) 48-54. 4. John G
Thomas, Khaled Seifelnasr, Maximizing Clinical
Benefits of Probiotics Matching Metagenomics,
Patient Age and Microbial Composition. Oral
Health Journal, December 2013.
Joint Health 2 Article - Arthritis