????????? ??F???????? ???? ??? ???????????? ???OS

1
????????? ??F???????????? ??? ???????????? ???OS

• G. ???S???O??S

2
S?G????S? S??F?????O?

• ???????

3
?????? ?????S??

• ??????F?S??? ?????S ????????S
• ? ???????? ???S?S ????? ????? ???G??????
• ?O??
• ??F???????? ???G????S

4
??????S? ??????? ?????

• L-????????????????
• ?????????????S
• L-????G???????? ???

5

• ??? ?????? ?? ???T???
• S?? ???????? (??S? ??T?S)
• ??? ?? ???T??? S?? ?????
• ????? ??S?S???? (???F?G? ???????G??S ???????)

6
??????????????S G?? ??? ?? ??F????????

• S?????????????????? ??? ?.?.
• ???S? ?????G??? S??S? ?? ?G?? ??????
• ???S? ????S???F? S??S? ?? ??????
• ???S? ????S???F? S??S? ?? ????????????
• ???S? ????S???F? S??S? ?? T????????

7

• T???????? ????????????S I.R. ?? MELTING DOWN
  F???????? ?S???? ????OS G?? ?? ?.?. (I.R.)
• ?S???? T?????S? (?? LASER ????????S
  ???????????)
• ??OS??? ?.?.
• ????G? ?F?S SF??????O? ?O? ???G???O? ????S?
  ?S????S ?????????S ???????S?S

8
L-????G???????? ???

• ?????????? S? ???SO?? ??
• ??G??? ?????????
• ???G?? ??????? ?G??? S? ??GO?????? GO???S G??T??

9
L-????G???????? ???

• ??T??? S?? ????????
• ??????????S S??????S??S ??????? ????????S
• ??? ???S? ????TOS? (11)
• (??????S STOP WHEN YOU THINK THAT YOU MAY NEED A
  LITTLE BIT MORE

10
L-????G???????? ???

• ???????S ?G??S??S
• ??? ????????TOS? F?S???
• ????????????????S S???????S
• ??T? ??SS?? (??????S ??? 5)

11
L-????G???????? ???

• ????OS? ?????????? 4 ml WATER FOR INJ ?O?? 8-10
  ml
• ??????? 1-2 O??S
• ???S? ????S 72 O?O?
• ???ST??? 2 ml ?????????S

12
?????????????S - RAPIESSE

• ?????SF??????? Ca Ha 25-40 µm
• F????S ??????? G??? ?????????T????????????S
• ????? ?S?????? ?F????GO? O?? G??T????????G???
  ??T??????? O??

13
RADIESSE

• ????????S
• ????????????S
• ??????S T????S (LIFT ??S GO???S)
• G???S?? ?????O?
• ??GO??????
• ??G????
• ???? ????S

• ???
• ?????S
• ?????FT??????
• ???????? ?????

14
RADIESSE

• ??????S??S ???S?S
• ???????S? ???????
• ?????T?S? ?????G???? S?? ?????SF???????
• ???????S? ?O? ?????SF??????O? ?? ??? ?S??
• S??????? (18-24 µ??e?) ???????S? F?G?????OS?
  ?O? CaHa

15
????????

• S??S ???????S ?? ????????????
  8-12 ????S
• S??S ??G????? ????????S
  12-14 ????S

16
RADIESSE

• ???????
• ?????? 27G / 12-14 mm
• ?? ?O ??T?? ????? (???? ?? ????????)
• GO??? ??????S ???S ?? ????O
• ??? ????? ???? ??? ???S??S?
• ?? ??????T?? ?S???? ??????

17
RADIESSE

• ?????T?????S ???S??S
• ??G?S ?????? ??????? (??? ??? ?T???S? ??????)
• ?????O????
• ?????OS??S
• ??? ??????? ????????S ???G?????? ?GOG? ??
  ???????S????????

18
???S??? ???

• ???????????
• ?S??????
• ?S?F
• ???????? ?
• GINGO BILOBA
• ???S????????
• ????????

19
???F????? ??? ?????OS??S

• Caps Arnica 200
• 1 ??? ????? ????
• 1 ??? ????? ?F????G?S
• 1 ?????S?OS ??? ??? ?????S ????
• ????? ??????
• ???????!!!

20
L-???????????????? (PCL) (ELLANSE)

• F????S ?????????T??????????? (70)
• ????G? ????? SO??????? PCL (30)
• ? F????S ????? ????F??? ???????? ?????
• FDA GRAS (Safety) approved
• ??? ?OS 30-40 ?????S

21
ELLANSÉ

• ?? ????? ?? PCL
• ????????S ???????????????O? ????O? PCL (???S???)
• ?? n ??T?????? ?? ????S ??S ???S???S ??? ??? ??
  ?????? ??????? ????S ??? ?????????S

22
Polymer Applications

• Wound management
• Sutures
• Staples
• Clips
• Adhesives
• Surgical meshes
• Orthopedic devices
• Pins
• Rods
• Screws
• Tacks
• Ligaments

• Dental applications
• Guided tissue regeneration Membrane
• Void filler following tooth extraction
• Cardiovascular applications
• Stents
• Intestinal applications
• Anastomosis rings
• Drug delivery system
• Tissue engineering

PCL Well-known bioresorbable medical polymer,
used in numerous CE and US FDA approved medical
devices for over 20 years. Extensive studies on
safe use as biomaterial
PCL has been used in many medical applications
including in medical devices such as in
orthopedy, maxillary surgery. PCL has also been
widely used in sutures. On the other hand, it has
been used as a drug delivery system releasing
various drugs especially cancer drugs,
contraceptives.
23
PCL ?????SF??????? (ELLANCE)

• ????? 25-50 µm, ?????G??OS ????????????
• ?????? ?????????S???? ?? ????S ??S ???S???S
• ?????????????? ????????S ??? ???????S????S

24
PCL ?????SF??????? (ELLANCE)

• ?????????? ?????G?S ????????S ???????S????S
• CE FDA ?G???S??S

25
PCL ?????SF??????? (ELLANCE)

• ?????????S????
• ???S? ????TOS? (CMC gel)
• ???G??S? ?????G????
• ?????????????? ????????S

26
(No Transcript)
27
??????S??S ???S?S

• ??????F?S? ??? CMC
• ?? PCL ?????SF??????? ?????? ?????????? ???S
  ??????S??S G?? ????GOG? ???? ?????G????
• ??????? ???????????? ??????F?????? (???? CO2)

28
??????????? ????????
Nicolau PJ et al. Eur J Aesth Med Dermatol 2013

• S? ??????????O? (RABBIT TISSUE)
• 9 ????S ???? (?)
• ?? ?????? ?T???? ?????SF???????
• ???S ???S ?????G???? (???T??)
• ???O???? FOS ?? PSR (PICRO SIRIUS RED)
• ???T?? ???? ?????G??? ????? ?
• ???S??? ????? ???
• (?????G???G???S?)
• 21 ????S ???? ????????T?? ?? ????????? ??
  ?????G??? ?

29
??????????? ????????
Kim et al. Neocollagenesis in human tissue
injected with a polycaprolactone based dermal
filler. J. Cosmet Laser Ther 2014

• 13 ????S ???? ?? ? G??O ??? ?? SF???????
• ???????? ????GOG? ?????T?S? ?????G????
• ???? ?S???????????? ??????S???? ???T?S? (??
  Martins 3C)

30
S???????? ????S??S? ???S?S ?????????F?S?S
31
? ??????S? S?? ?.?.
32
?SF????? OS ???S ??? ?S???? ???????S?

• ?S? ??? ????? ??? SF????????S ????? ? ???F?????
  ??? ????? SO????S ??S? ???O?????? ??????F?????
  ?? ??T???????S ?????T?????S ?S????S ???????S?S

33
????????S

• ????????S ?? ??? ?????????????
• ?????
• ?????FT??????

34
???S???S ???G??S G?? ???F?G? ?????O?

• ??G? ?G??S?
• ?????? ???F??
• ??? ????????TOS?
• BOLUS ??? ??G??????? ??? 0.2 ml

35
(No Transcript)
36
(No Transcript)
37
???????S ??????S

• Moers Capri Dermatol Surg 2013 (457-63)
• Galaradi H J Cosmet Dermatol 2015 (Split Face µe
  HA)
• Figueiredo J cosmet Dermatol 2013

38
(No Transcript)
39
(No Transcript)
40
Sa? e??a??st?