SURVEY OF BIOCHEMISTRY Course Review

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SURVEY OF BIOCHEMISTRYCourse Review
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PRS-1

• Catalytic efficiency is given by what expression?
• kcat
• kcat/KM
• Vmax/KM
• ET x kcat

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PRS-1

• Catalytic efficiency is given by what expression?
• kcat
• kcat/KM
• Vmax/KM
• ET x kcat

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PRS-2

• Which amino acid is an alpha-helix breaker?
• Y
• W
• V
• P

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PRS-2

• Which amino acid is an alpha-helix breaker?
• Y
• W
• V
• P

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PRS-3

• Amino acids are linked by what types of bonds in
  proteins?
• Disulfide bonds
• Peptide bonds
• Both 1 and 2
• None of the above

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PRS-3

• Amino acids are linked by what types of bonds in
  proteins?
• Disulfide bonds
• Peptide bonds
• Both 1 and 2
• None of the above

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PRS-4

• Which cofactors are required for the aldolase
  reaction?
• NAD
• CoA
• FAD
• None

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PRS-4

• Which cofactors are required for the aldolase
  reaction?
• NAD
• CoA
• FAD
• None

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PRS-5

• Which of the following is NOT an example of a
  cofactor?
• Glucose
• Thiamine Pyrophosphate
• Pyridoxal Phosphate
• Coenzyme A

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PRS-5

• Which of the following is NOT an example of a
  cofactor?
• Glucose
• Thiamine Pyrophosphate
• Pyridoxal Phosphate
• Coenzyme A

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PRS-6

• What function does glucagon exhibit?
• Increasing glycogen breakdown
• Binding to receptors on liver cells
• Triggering increased levels of cAMP production
• All of the above

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PRS-6

• What function does glucagon exhibit?
• Increasing glycogen breakdown
• Binding to receptors on liver cells
• Triggering increased levels of cAMP production
• All of the above

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PRS-7

• Pyruvate carboxylase converts ___ to _____.
• Acetyl CoA to pyruvate
• Pyruvate to acetyl Coa
• Pyruvate to Oxaloacetate
• Pyruvate to Phosphoenolpyruate

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PRS-7

• Pyruvate carboxylase converts ___ to _____.
• Acetyl CoA to pyruvate
• Pyruvate to acetyl Coa
• Pyruvate to Oxaloacetate
• Pyruvate to Phosphoenolpyruate

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PRS-8

• A point mutation in which a purine is replaced by
  a pyrimidine is called
• Transversion
• Transition
• Insertion
• Deletion

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PRS-8

• A point mutation in which a purine is replaced by
  a pyrimidine is called
• Transversion
• Transition
• Insertion
• Deletion

See Section 25-4 From Reading - not mentioned in
lecture
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PRS-9

• Which statement is true?
• Hemoglobin binding of CO2 stabilizes the T form
• The sickle cell form of hemoglobin contains a
  point mutation (E-gtV)
• 2,3-Bisphosphoglycerate decreases hemoglobins
  affinity for O2
• All of the above

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PRS-9

• Which statement is true?
• Hemoglobin binding of CO2 stabilizes the T form
• The sickle cell form of hemoglobin contains a
  point mutation (E-gtV)
• 2,3-Bisphosphoglycerate decreases hemoglobins
  affinity for O2
• All of the above

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PRS-10

• Which of the following is a unit of O2 pressure?
• mm Hg
• mol/L
• nm

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PRS-10

• Which of the following is a unit of O2 pressure?
• mm Hg
• mol/L
• nm

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PRS-11

• See Figure 1. The shift from blue to red
  indicates
• An increase in pH
• A decrease in pH
• An increase in hemoglobin concentration
• A decrease in hemoglobin concentration

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PRS-11

• See Figure 1. The shift from blue to red
  indicates
• An increase in pH
• A decrease in pH
• An increase in hemoglobin concentration
• A decrease in hemoglobin concentration

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PRS-12

• Which are 5-C monosaccharides?
• Glucose and ribose
• Ribose and fructose
• Ribose and mannose
• None of the combinations above

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PRS-12

• Which are 5-C monosaccharides?
• Glucose and ribose
• Ribose and fructose
• Ribose and mannose
• None of the combinations above

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PRS-13

• Which reaction is an example of an acid-base
  catalyzed reaction?
• Hexokinase
• Pyruvate kinase
• Phosphoglucose isomerase
• Pyruvate dehydrogenase

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PRS-13

• Which reaction is an example of an acid-base
  catalyzed reaction?
• Hexokinase Nucleophilic attack
• Pyruvate kinase Nucleophilic attack
• Phosphoglucose isomerase
• Pyruvate dehydrogenase5-step Reaction

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PRS-14

• Which of the following is not a step in the
  pyruvate dehydrogenase mechanism?
• Decarboxylation
• Reduction of FAD to FADH2
• Oxidation of NADH to NAD
• Production of acetyl-CoA

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PRS-14

• Which of the following is not a step in the
  pyruvate dehydrogenase mechanism?
• Decarboxylation
• Reduction of FAD to FADH2
• Oxidation of NADH to NAD
• Production of acetyl-CoA

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Pyruvate Dehydrogenase Rxn
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PRS-15

• Which of the following is not a disulfide
  reducing agent?
• Cysteine
• Beta-mercaptoethanol
• Lipoic acid
• Linoleic acid

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PRS-15
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PRS-16

• cDNA _____.
• Is DNA found in the cytosol of a cell.
• Comes from reverse transcription of mRNA.
• Stands for capped DNA.
• Contains the DNA sequence from the entire genome.

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PRS-16

• cDNA _____.
• Is DNA found in the cytosol of a cell.
• Comes from reverse transcription of mRNA.
• Stands for capped DNA.
• Contains the DNA sequence from the entire genome.

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PRS-17

• Which are nonpolar amino acids?
• Gly, Val, Lys
• Arg, Leu, Met
• Ile, Pro, Phe
• Ala, Met, Ser

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PRS-17

• Which are nonpolar amino acids?
• Gly, Val, Lys
• Arg, Leu, Met
• Ile, Pro, Phe
• Ala, Met, Ser

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PRS-18

• Beta sheets can contain _____.
• Antiparallel strands
• Parallel strands
• Interstrand H-bonds
• All of the above.

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PRS-18

• Beta sheets can contain _____.
• Antiparallel strands
• Parallel strands
• Interstrand H-bonds
• All of the above.

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PRS-19

• The hydrophobic effect is driven by ______.
• Enthalpy
• Entropy
• The concentration of water
• Temperature

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PRS-19

• The hydrophobic effect is driven by ______.
• Enthalpy
• Entropy
• The concentration of water
• Temperature

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PRS-20

• Which is a major component of brain lipids?
• Fatty acids
• Triglycerides
• Gangliosides
• Phospholipids

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PRS-20

• Which is a major component of brain lipids?
• Fatty acids
• Triglycerides
• Gangliosides
• Phospholipids

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Reminders

• Final exam is closed-book.
• Bring a calculator.
• Study by
• Reading the text
• Reviewing suggested HW problems
• Reviewing What You Should Know summaries (no more
  added)
• Reviewing past exams
• Studying lecture notes

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CETL Course Survey(s)

• Course-Instructor Opinion Survey (CIOS)
• http//www.coursesurvey.gatech.edu
• Also on T-Square Home Page
• Pilot Survey
• Go to T-Square Announcements for link to survey
• Focus groups to learn more about student opinions
  
• Deadline August 3, 2008
• IRB Approval requested minimal risk