A

1
abcd
A
B
abcd
1.6
4
ab
ab
1.2
a
3
Apoptosis
Proliferation
bcd
ab
ab
ab
abcd
ab
a
0.8
abcd
2
a
ab
ab
a
0.4
1
0
0
Supplementary Figure 5. Effect of Doxorubicin
(DR) treatment and concomitant inhibition of the
ERK cascade by the MEK/MAPK inhibitor U0126 (U0
20µM) and/or the JNK inhibitor SP600125 (SP
10µM) in the HuH6 cell line on proliferation (OD
450 nm) and apoptosis (OD 405 nm). Data are means
SD of 9 experiments. Equivalent data were
obtained in HepG2, HuH7, and HLE cell lines (not
shown). Data from non-transfected cells and from
cells transfected with empty vector did not show
any significant difference and were, thus,
merged. Abbreviations C, not transfected/empty
vector U0, U0126 SP, SP600125. Statistical
analysis a, different from C, Plt 0.001 b,
different from DR, P lt 0.001 c, different from
DR U0, Plt 0.001 d, different from DR SP, P lt
0.001.