????????????,????????(NSAIDs)

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Antipyretic, analgesic, and anti-inflammatory
drugs

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• ????????????,????????(NSAIDs)

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  1.??
• 2.??
• 3.??
• ?? ?????(cyclo-oxygenase,COX), ?????????

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????
???
PLA2
?????
NSAIDs
COX
TXA2???
PGG2 PGH2
5-HPETE
PGI2???
(???)
(??)
LT3
TXA2
PGF2a
PGE2
PGI2
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???? ???(???-1) AH/POA COX
PG??
????
???? ???? AH anterior hypothalamus
POA preoptic area COXcyclo-oxygenase
NSAIDs
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• ???, ????????
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Bradykinin ???

• doner receiver

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????
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PGs
???????
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• PGs??????????
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• ??? NSAIDs?????
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????

• COX??????
• COX1 ??????, ?????
• COX2 ???????, ????
• NSAIDs???????,??????????????????

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???? Salicylates ???? aspirin (??????
acetylsalicylic acid)
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???? t1/2 15?? ??? t1/2 2-3??
????,???? ????, ?????, t1/2??
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• ???????(MTD)
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• ?????(75100mg/d)
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???? 1.????? 2.???? 3.???? 4.?????
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????

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• ???PGs?????????
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• AD????
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??NSAIDs??

• ??????(????)
• Acetaminophen (paracetamol) ???? Phenacetin

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????????? ???? ????COX3??????
??????(????? ??????) ???? ???????,????
????????????
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???? Pyrazolones ??? Phenylbutazone
???????,?????. ????? ???Analgin,Novalgine
??????.
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???? Indomethacin ??PG????
???????,?????. ????? 1.????? 2. ????
3.?????? 4.????
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??? ??? Ibuprofen ?????????? ??????,??????.
???? ?????? ???????????
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???COX-2??? ???? meloxicam ??PG?????????
?????,???? t1/2 20 ?? ???( 7.5-15mg/?)
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??? ???????? ???
??? ?????? ??PG??? ????? ????? ????
?????? ??????? ???? ???????
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