Pathology%20of%20Cardiovascular%20Disease%20(CVD)

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Pathology of Cardiovascular Disease (CVD)

• Higher Human Biology

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• CVD is responsible for a huge proportion of
  deaths annually

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Atherosclerosis

• Formation of plaques (atheromas) beneath the
  endothelium in an artery
• Start off as mainly fatty material (cholesterol)
• Become enlarged due to collecting fibrous
  material, calcium and more cholesterol

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• Larger atheromas can lead to
• Significant reduction in diameter of arteries
  lumen
• Restriction of blood flow to the capillary bed
  served by that artery
• An increase in blood pressure

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• Large plaques hardened by deposits of calcium
  cause arterial walls to become thicker and less
  elastic
• hardening of the arteries

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• Symptoms of atherosclerosis come on in later life
• Can lead to various cardiovascular diseases
• Coronary heart disease (inc. angina)
• Strokes
• Heart attacks (myocardial infarctions)

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• Atherosclerosis can also cause peripheral
  vascular disease

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• http//www.nhs.uk/video/Pages/coronary-arteries-an
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