Quantification of MR Spectra in Human Brain using LCModel

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Quantification of MR Spectra in Human Brain using
LCModel

• Shireen Farvin HM-Meeran
• Masters in Bio-Medical Engineering
• Wayne State University
• Thesis Committee Members
• Dr. Jiani Hu
• Dr. E. Mark Haacke

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Research Interest

• Automatic quantification of in vivo proton MR
  spectra using LCModel.
• To estimate metabolite concentrations
• Normal Human brain and Various Tumor cases at 4T
  field strength.

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Methods

• The metabolite concentrations were obtained using
  LCmodel quantification algorithm.
• LCmodel analyses the in vivo spectrum as a linear
  combination of individual in vitro metabolite
  spectra that constitute a basis set.
• The basis set used in this study consisted of
  spectra from the following metabolites NAA,
  choline, creatine, glutamate, glutamine and GABA.

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BASIS-SET
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BASIS-SET
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Test Phantom Results
The ultimate goal of this research is to apply
this basis-set on Traumatic Brain Injured
patients to estimate the metabolite
concentrations.
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Thank You!!!