????????????????????,????????????????????????,?????Nephrolepis multiflora (Roxb.) Jarrett ex

1
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• ????????????????????,????????????????????????,????
  ?Nephrolepis multiflora (Roxb.) Jarrett ex
  Morton??????,???????????????????????,????????????
  ?????,????????????????????????????????????????????
  ???,??????????????????n-BuOH?????????,???5-hydroxy
  methyl-2-furaldehyde (1)?2-hydroxy-5-hydroxymethyl
  furan (2)?5-(a-D-Galactopyranosyloxy)methyl-2-fu
  rancarboxaldehyde (3)?loganin (4)?paeoniflorin
  (5)?oxypaeoniflorin (6)????n-BuOH?????????,???cat
  alpol (7)?dihydrocatalpol (8)?ajugol
  (9)?scutelloside (10)?uridine (11)?sucrose
  (12)?raffinose (13)?stachyose (14),??scutelloside?
  ??????????????,?????????????,?????????????????arct
  igenin (15)?arctiin (16)?palmitic acid
  (17)???????????ethyl-ß-D-fructopyranoside
  (18)?shikimic acid (19)?ethyl shikimate
  (20)?matairesinoside (21)?astragalin
  (22),?compound 1516 ?1921????????????????????,??
  C2C12 cell glucose uptake???,?????????compound
  1?4,?????compound 7?8?13,??????compound
  19?20??????????loganin (4) ? catalpol (7)
  ????????,compound 1?8?13?19?20????????glucose
  uptake???????????,??catalpol (7)
  ?rdihydrocatalpol (8) ??????????,?????????????????
  ?

2
Studies on the Hypoglycemic Constituents of
Liuwei Dihuang Pills and Nephrolepis multiflora

• In this study, bioactive constituents of Liuwei
  Dihuang Pills and Nephrolepis multiflora (Roxb.)
  Jarrett ex Morton were investigated. n-BuOH
  extracts of Liuwei Dihuang Pills and CH2Cl2
  extracts of Nephrolepis multiflora (Roxb.)
  Jarrett ex Morton are obviously hypoglycemic
  activity. Rehmannia glutinosa Libosch. is the
  principal herbs (jun yao) of Liuwei Dihuang
  Pills. When Rehmannia glutinosa Libosch. (di
  huang) has been just prepared by drying and
  steaming. They are called sheng di huang (means
  raw) and shu di huang (means cooked),
  respectively. Investigating the changes in
  chemical components of Rehmannia glutinosa
  Libosch. during processing. Through all kinds of
  different solvents and chromatography system, a
  total of 22 compounds isolated. The known
  compounds which have isolated from the n-BuOH
  layer of Liuwei Dihuang Pills are
  5-hydroxymethyl-2-furaldehyde (1),
  2-hydroxy-5-hydroxymethylfuran (2),
  5-(a-D-Galactopyranosyloxy)methyl-2-
  furancarboxaldehyde (3), loganin (4),
  paeoniflorin (5), oxypaeoniflorin (6). The known
  compounds which have isolated from the n-BuOH
  layer of Rehmannia glutinosa Libosch. (sheng di
  huang) are catalpol (7), dihydrocatalpol (8),
  ajugol (9), scutelloside (10), uridine (11),
  sucrose (12), raffinose (13) and stachyose (14).
  Scutelloside (10) is the first report of
  Rehmannia glutinosa Libosch. As for the compounds
  which have isolated from the CH2Cl2 layer of
  Nephrolepis multiflora ( Roxb. ) Jarrett ex
  Morton are arctigenin (15), arctiin (16) and
  palmitic acid (17). In addition, the compounds
  which have isolated from the CH2Cl2 layer of
  Nephrolepis multiflora ( Roxb. ) Jarrett ex
  Morton are ethyl-ß-D-fructopyranoside (18),
  shikimic acid (19), ethyl shikimate (20),
  matairesinoside (21) and astragalin (22).
  Compound 1516 and 1921 are the first report of
  Nephrolepis multiflora ( Roxb. ) Jarrett ex
  Morton. Among them, 5-hydroxymethyl-2-furaldehyde
  (1), loganin (4), catalpol (7), dihydrocatalpol
  (8), raffinose (13), shikimic acid (19) and ethyl
  shikimate (20) can enhance glucose uptake in
  C2C12 experiment. Catalpol (7) is the indicator
  compound in sheng di huang. The content of
  dihydrocatalpol (8) in sheng di huang is more
  than the shu di huang. Therefore, the
  hypoglycemic activity of sheng di huang is better
  than the shu di huang.