Synthetic Biology

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Synthetic Biology
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Synthetic Biology
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What is Synthetic Biology?
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Discover Magazine Scientists of the Year
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Undergraduates in Synthetic Bio.
international Genetically Engineered Machines
http//parts.mit.edu/registry/index.php/Main_Page
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37 Teams in 2006 57 in 2007
http//parts.mit.edu/r/parts/igem/team_list.cgi
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Registry of Parts - iGEM Resource
http//parts.mit.edu/registry/index.php/Part_Types
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Lego Assembly for DNA Parts
http//parts.mit.edu/registry/index.php/AssemblyS
tandard_assembly
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What can you make in SB?
Self-organized Pattern Formation
Arsenic Detector
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Davidson and MWSU Join Forces
2006 iGEM Teams
http//parts2.mit.edu/wiki/index.php/Davidson_2006
http//parts2.mit.edu/wiki/index.php/Missouri_West
ern_State_University_2006
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Burnt Pancake Problem 2006
Sorting stacks of burnt pancakes
DNA Pancakes order and orientation
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Davidson Missouri Western 2006
http//www.bio.davidson.edu/people/kahaynes/FAMU_t
alk/Living_computer.swf
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Modeling Pancake Flipping
-2 1
-2 -1
A3 1 2 -1 2 -1 -2 1 -2 -2 -1 -2 1 2 1 2 -1
1 2 0 7 0 7 7 0 6 0
-1 2 7 0 7 0 0 7 0 6
-1 -2 0 7 0 7 6 0 7 0
1 -2 7 0 7 0 0 6 0 7
-2 -1 7 0 6 0 0 7 0 7
-2 1 0 7 0 6 7 0 7 0
2 1 6 0 7 0 0 7 0 7
2 -1 0 6 0 7 7 0 7 0
2 1
2 -1
R2 2 Burnt Pancakes 8 vertices, each with degree
3 Each path taken with probability 1/27
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Pancake Graph Theory
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Five Prizes in 10 Categories!
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Five Prizes in 10 Categories!
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MO Governor Meets MWSU iGEMmers
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Hamiltonian Path Problem 2007
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Davidson Missouri Western 2007
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Split GFP Works!
http//www.bio.davidson.edu/Courses/Immunology/Stu
dents/spring2006/Acker/GFP_halfframe.html
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Traveling Salesman Problem 2007
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SB Blends Math and Biology
HHMI Proposals Due Fall, 2007
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Is SB hard or expensive?

• Hire rising sophomores
• Less than 5,000 in lab expenses
• NSF Undergraduate Biology and Math Program
• Protocols student-proof and online
• Creativity and fun encouraged
• Existing lab equipment and methods
• Math modeling improves design
• Fun iGEM competition stimulates students

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How can SB fit into a curriculum?

• Seminar course to prepare
• Research or Independent Study to build
• Summer research programs
• Existing Courses Molecular Biology, Genetics,
  Cell Biology, Development, Microbiology,
  Biochemistry, Engineering, Modeling, Lab
  Methods...

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How can we learn more?

• Attend iGEM 2007 in Boston
• Read synthetic biology paperswww.bio.davidson.edu
  /Courses/Synthetic/read.html
• Familiarize yourself with iGEM wiki
• Form an iGEM team on your campus
• Put Synthetic Biology in your HHMI proposal

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Is GCAT participating in iGEM?

• Encouraging PUIs to join the fun
• Including iGEM in HHMI request
• Sharing protocols
• Making List-serve available

• Synthetic biology workshops possible
• Develop curriculum and resources to share

http//parts.mit.edu/igem07/index.php/Davidson_Mis
souri_W