Motic Digital Pathology Solution ???????????

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MOTIC VM600 Virtual Microscope Development of
Motics New ModelFeatures Improvements, Model
Strategy, and Model Competition Motic
International Dealer MeetingMarch 2009
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Topics Covered

• Motic VM Introduction Hardware Softwares
• Application solutions
• Clinical Diagnosis/
• Consultation, Research
• Education
• VM System Operation software
• Competitive Analysis

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Motic Products Solution
www.moticpathology.com
1?DPCC( Digital Pathology Consultation
Communication Platform )
VM600-4Digital Slide Scanner
www.motic.com/dssweb
2?DSS( Digital Slide Server System )
VMDigital Slide View software
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Motic VM Components (Hardware Scanning
software))
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Scanning Process Demo
Scanning
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Digital Slide View Demo
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Motic Pro 285 CCD
1. Motic 285A 2/3 " , 1360 x 1024, 6.45?m x
6.45?m
MCAM285 Technical Data MCAM285 Technical Data
Item MCAM285
Sensor Size 2/3"CCD
Resolution 1.4 mega pixels, 1360 X 1024 pixels
Pixel Size 6.45?m x 6.45?m
Frame Rate 15 fps / second
Shutter Electronic
Dynamic Range gt44db S/N
Scanning System Progressive
Minimum Illumination 3Lux
USB Interface USB2.0(480Mbit/sec
Voltage DC 5V 5
Operating Current 260mA
Power Consumption 1.3W
Operating Temperature 0?-50?
Storage Temperature 0?-60?
Relative Humidity 40-80
OS recommended WINDOWS2000 / WINXP / VISTA
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Scanning Speed
Objective 20x Specimen10mmx10mm Scanning
Method Standard SpeedAbout 4 min
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VM600 Stage Configuration

• X - 272mmY - 196mmZ - 93mm
• Travel range of 80mm by 24mm
• Stage Accuracy
• 1.5625um for x/y axis,
• 0.015um for z-axis
• Relocation Accuracy lt1um

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Motic VM600 Recommended PC Specifications

• Workstation System
• Windows XP Professional
• Intel Core(TM) 2 processors
• 4GB RAM
• 300GB disk storage
• 22 Monitor(or larger Optional)

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Motic VM Scanning Methodology
1. High Precision Auto Focus every Image
, high quality 2. Standard Build
Scanning model , good quality with faster
scanning speeds 3. ROI(Region of Interest)
Scan whole slide with low magnification(2x or
4x) first, then scan ROI with higher
magnification . Small Digital slide Size(lt10M),
useful and convenient for pathology or
educational applications (Motic only
feature) 4.Multilayer Focus Multilayer
focus and amalgamation each tiled image . Very
high quality ,especially for thick glass slide
(but may be too slow for most applications)
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Multilayer Focus Scanning
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Multi-Layer Amalgamation
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Traditional Pathology Workflow
Surgery Center
Pathology Center
Fix, Dehydrate, Embedding.
Histo-processing
Slide
Staining
Tissue specimen
Pathology Education
Pathology Diagnosis
Slides
Pathologist Center
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Digital Pathology Solution Adjusting Standard
Workflows
Surgery Center
Pathology Center
Living specimen
Fix, Dehydrate, Embedding.
Histo-processing
Slide
Staining
Slide
Freezes Tissue
Tissue specimen
Education
Image Analysis
Pathology Diagnosis Analysis
Workflow Management
Pathologist Center
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Future Digital Pathology Directions

• Information Workflow, including Digital Slides
• Integrated Patient records (HIS/PACS)
• Education Clinical
• Remote-Consultation
• Image analysis

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MOTICs Digital Development Makes the VM600 The
Next Logical Progression
Microscope
Digital Pathology
MicroCamera
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VM Application Solutions
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VM600 Digital Slide Applications

• Educational (Cell Morphology, Histology,
  Pathology, etc.)
• Digital Slides Classroom Teaching
• Remote Teaching and Learning
• Virtual (Web) Teaching Lab for Images view and
  conference
• Clinical Diagnosis(Pathology)
• Digital Images Data and workflow Management
• Remote Consultation
• Digital Slides Conference
• Aided Diagnosis
• Research
• Digital Slides Data
• TMA
• Image analysis
• Pharmaceuticals

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VM Educational Applications
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Digital slides Education System for Pathology
and Histology Teaching

• Classroom Teaching
• 1. Digital Slides reduce concerns about
  slide making, loss, breakage or fading
• 2. Archive and share critical slides
• 3. Built-in Digital Slide information
  management to reduce teacher prep time for
  course development and dedicate more time to
  viewing
• Digital slides Testing
• 1. Manage digital slides to create a test
  library as an effective means for distributing
  testing materials
• 2. Auto testing
• Digital Slides gallery( Web view)
• 1. Anywhere , anytime access via internet
  on web, Pre- learning and Review
• 2. Improving the teaching level and
  learning effectively

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Motic Digital Slides Server Software System(DSS)

• Lan/Internet

IE View
DSS Server
Web-Based
IE View
workstation
Motic VM
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Motic Digital Slides Server System(DSS)
Web-Based
View by annotation , convenient for teaching and
learning
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Incorporating VM600 with Motic Net as an
effective teaching tool..
Education (VM600 with Motic Net)
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For Pathology Diagnosis (Secondary) Consultation
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Motic VM Feature Observe slide by Motic
VM whiling or after scanning the slide ,it is the
best way for beginning of diagnosing training
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Digital Pathology Consultation digital slide
Communication Platform
Remote Experts
DPCC Platform
LAN or Internet (ADSL)
Remote Consultation Center
LAN or Internet (ADSL)
Motic VM
Consultation station
On business or at home
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Motic DPCC Platform Web Address
http//www.moticpathology.com
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Digital Pathology Information Workflow
Motic VM
HIS
Info Management
Patient Information
PIS
Digital Slides
Workflow
Remote Consultation
Report
Conference
Internet)
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Competitive Analysis
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Market Sector Competitors

• Zeiss Mirax
• Olympus Bliss HD or .slide
• Aperio
• Hamamatsu NDP
• Nikon Coolscope
• 6. Claro
• 7. DMetrix

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Zeiss
Mirax DESK(1-slide)
Mirax MIDI(12-slide)
Mirax SCAN(300-slide)
Objective Plan-Apochromat 20x/0.8 Scan camera
SONY DFW-X710 or others
(1/3inch, 1024 x 768 pixels, cell size 4.65 x
4.65 µm ) 
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Zeiss (3DHISTECH,Hungarian company)
MIRAX Viewer - the virtual microscopeMIRAX MFM
- fluorescent slide viewerMIRAX TMA - a powerful
tool for high throughput tissue microarray
evaluationIH-Lab - software for fast evaluation
of immunohistochemistry stained
samplesHistoQuant - quantitative and qualitative
analysis applicationMIRAX E-School - teaching
material authoring tool with exam moduleMIRAX 3D
- an application for 3-dimensional reconstruction
of serial slidesE-Consult teleconsultation
softwareMIRAX DB - database program for
efficient data managementToxicoPath-LIS -
application for the management and administration
of toxicopathology research
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Olympus
Dot slide(1-slide/50-slide)
Objectives 2x PLAPON, 10x, 20x, 40x UPLSAPO,
optional, e.g. 100x oil Illumination brightfield
with 100 W halogen lamp house, optional
fluorescence, polarisation Digital CCD camera
2/3 CCD camera, 6.45 µm x 6.45 µm pixel
size Software functions and modules .View images
locally, zoom, crop and rotate images .Net Image
Server software for remote access to virtual
slides with dotSlide software .Conferencing
module for simultaneous and synchronised viewing
of virtual slides, conference access control and
user management, minute taking tool, chat
function .TMA module to acquire individual images
of TMA cores
Bacus Bacus Laboratories,inc., a wholly-owned
subsidiary of Olympus America . Founded in 1994,
is a leader and innovator in the field of VM.
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Hamamastu
NDP 210-slide
Objective lens 20X, NA 0.7 CCD TDI
sensor,4096 x 64 pixel , Line scanning Software
Developed by other company
Distributed now in the USA through the Olympus
network, approx cost 120K
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Aperio
Objective lens PLAN-APO 20x / 0.75 CCD
Line 3-CCD, 1040 x 1 pixel
120-slide
5-slide
1 -slide
1-slide(Oil)
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NikonCoolScope
CCD2/3-inch. (total number of pixels 5.24-mega
pixels effective 5.07-mega pixels)
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Dmetrix
.Objective Array Micro lens (80) .The fastest
scanning system
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Claro(Japan)
Toco 1-slide
VS0201AS1 20-slide
VS0801AS1 80-slide
Objective Carl Zeiss Aplan 20x, 40x Camera
1/2 CMOS (1280 x 1024) or 1/2 IT CCD' (1280 x
960)
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Clarient/Trestle/Dako
Clarient formed in 1996 to develop and market
the ACIS(R) Automated Cellular Imaging System, in
cancer diagnostics Sells Its ACIS
Instrument Business to Carl Zeiss for 12.5
Million
Following the acquisition of Trestle and of
Clarient's equipment business, Carl Zeiss has
become the leading provider of solutions for
telepathology, digital slides and computer-
supported diagnostics with more than 500
installed systems.
In marketing a clinical version of the system,
Carl Zeiss MicroImaging said it is collaborating
with the Danish diagnostics company Dako, a
manufacturer of reagents for tissue-based cancer
diagnosis.
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Motics Strategic Positioning

• Natural Digital progression for Motic into
  Virtual slide making market
• Offer single-source complete and easy
  integrated with VM hardware and software
• Package Applications by combining VM Digital
  slide with Motic Net
• Highest Resolution Sony CCD
• Different scanning methods ROI slide for remote
  consultation
• Value-Alternative to customer

Motic Value-Based alternative to easy and
efficient digital slide creation and integration!