NORMAL SEXUAL DIFFERENTIATION

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NORMAL SEXUALDIFFERENTIATION

• Suganda Tanuwidjaja

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IDENTITAS GENDER

1. Genotype
2. Gonadale Sex
3. Phenotype Sex
4. Social Gender

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GENOTYPE

• Chromosomal
• (Genetic) Sex

Ovary-Determining Genes
Testis-Determining Genes
XY
XX
Gonadale Sex
Gonadale Steroids And Peptidas (T.DHT.AMH)
(Gonadale Steroids)
?
?
Phenotypic Sex
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CHROMOSOMAL SEX

• Male 46 XY
• Female 46 XX
• Y Chromosome (SRY Gene)
• Diff. of The Bipotential Gonad
• Testis
• X Chromosome
• One Dose Active

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GONADAL SEX

• Gonadal Sex is determined by SRY
• Indiff. Gonad (?SRY) Ovary
• (SRY) Testis

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• 1 X Chromosome ?SRY
• Gonad Ovary (Fetal Periode)
• Ova Atrophy
• (Only 1 Chr)

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STEROID METABOLISM OF GONAD
Androgen

• Cholesterol

Enzim
Estrogen
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PHENOTYPE SEX

• Internal Ducts
• External Genital Appearance
• Peran Androgen

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INTERNAL SEX DUCTS BIPOTENTIAL

• Masculine
• Wolffian Ducts

Feminine Mullerian Ducts
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TESTICULAR PEPTIDE PRDCT(SERTOLI CELL)

• Mullerian Duct Inhibitory Factor (MIF)

Mullerian Duct Atrophy
Wolffian Duct Developed
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WITHOUT...

• MIF

• Developed
• Uterus
• Oviduct
• Upper 2/3 of Vagina

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• LEYDIG CELL

Testosteron
Wolffian Ducts

• Epididymis
• Vas Deferens
• Seminal Vesicle

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EXTERNAL GENITALIA

• Bipotential 8 Weeks
• Genital Tubercle Clitoris
• Urogenital Fold Labia Minora
• Labioscrotal Swelling Labia Majora

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Dihydrotestosterone (DHT)

• Testosterone

5a Reductase Enzyme
Androgen Receptor (ARs)
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• Genital Tubercle

Penis
DHT ARs
Urogenital Slit
Penile Urethra
Labioscrotal Fold
Scrotum
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1st TRIMESTER

• Maternal Human Chorionic Gonadotropin
• (hCG)

Fetal Testes
Testosterone
Male Development
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2nd TRIMESTER

• Fetal Pituitary Gonadotropin

Testicular Activity
Further Normal Growth of The Penis
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SOCIAL GENDER

• Gender Development
• 1. Gender Identity
• 2. Gender Role
• 3. Sexual Orientation
• 4. Desire Capacity for Parenting

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DETERMINED FACTORS

• Surrounding
• Physical Differentiation
• Interaction
• Prenatal Androgen

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Thank You