Heck Reaction

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Heck Reaction
Late 1960, Heck developed Heck reaction.
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For Aryl halide or vinyl Halide
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With Alkyl Halide, no Heck reaction is possible
because of following reason.
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Good with Iodide or bromide, but not with
chloride due to less reactivity Good with psuedo
halide ArCOCl, ArSO2-Cl, Ar-N2X-, R-OSO2CF3,
-OSO2-Rf (Rfperfluoroalkyl), R-OSO2CH3, Ar-ArI
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For Aryl chloride, dippb 1,4-bis(diisopropylphosp
hino)butane
Activated with Cr(CO)3, and demetallation with I2
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For conjugate diene
aromatization
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Difference between Terminal Alkene and Cyclic
Alkene
Ag2CO3 is for retarding isomerization of alkene
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Heck reaction of 2,3-dihydrofuran derivative and
2-iodonaphthalene
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Asymmetric Heck Reaction
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Intramolecular Heck Reaction
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Natural Alkaloid, Synthesis of Dehydrobifoline
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Synthesis of Prostaglandin Precusor