Epstein-Barr Virus

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Epstein-Barr Virus
Brittany Seyler
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What is it?

• Herpes virus that infects B Cells and Epithelial
  cells- linked to malignancies in both
• Responsible for Infectious Mononucleosis
• 2nd most common

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Background

• Named after M. Anthony Epstein and Yvonne Barr in
  1961
• Humans are the only known reservoir

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Transmission

• Saliva
• Blood transfusions
• Infects 95 of the worlds population
• 90 of US population infected by age 25

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Symptoms

• Fever
• Fatigue
• Sore throat
• Swollen lymph glands
• Weight Loss
• Vomiting
• Hemolysis

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Demographics

• Occurs worldwide
• No racial predilection
• Occurs earlier in females than males

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Structure

• Crystal structure
• Linear, double stranded DNA
• spikes
• Viral envelope easily damaged
• Toroidal shaped core

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• Each Line Plot represents different antigens to
  the EBV over the incubation period of the virus
  as a whole.
• This scaling can be used in the testing of
  carriers, and previous carriers of the EBV

Representation Of Immuno response vs viral
incubation.
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Viral Detail

• FamilyHerpesviridae
• SubfamilyGammaherpesvirinae
• GenusLymphocryptovirus
• SpeciesHuman herpesvirus 4 (HHV-4)
• Associated with several forms of cancer, lymphoma
  in HIV patients, and believed to be associated
  with higher risks of autoimmune conditions in
  those affected.

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Prevention
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Sources

• http//www.cdc.gov/ncidod/diseases/ebv.htm
• http//www.ncbi.nlm.nih.gov/pubmedhealth/PMH000161
  7/
• http//emedicine.medscape.com/article/963894-overv
  iew
• http//www.pnas.org/content
• http//www.nature.com/nsmb/journal
• http//virus.stanford.edu/herpes/transmission.html
  
• http//bioweb.uwlax.edu

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Thank You )