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Title: Integrated Treatment for Trauma and Addiction: Seeking Safety


1
Integrated Treatment for Trauma and Addiction
Seeking Safety
  • Denise Hien, PhD, LI Node, Columbia University
  • Tracy Simpson, PhD, VAPSHCS, University of
    Washington
  • NIDA CTN Blending Conference
  • Seattle, WA
  • October 16, 2006

PLEASE DO NOT CITE CONTENTS OF PRESENTATION
WITHOUT PERMISSION OF THE AUTHOR
2
Scope of the Problem
  • 1 in 2 women in the U.S. experience some type of
    traumatic event (Kessler, 1995)
  • Approximately 33 of females under age 18
    experience sexual abuse (Finkelhor, 1994 Wyatt,
    1999)
  • Prevalence rates of PTSD in community samples
    have ranged from 13 to 36 (Breslau, 1991
    Kilpatrick, 1987 Norris, 1992 Resnick, 1993)
  • Studies have documented PTSD rates among
    substance using populations to be between 14-60
    (Brady, 2001 Donovan, 2001 Najavits, 1997
    Triffleman, 2003)

3
  • The past isnt dead, it isnt even past.
  • -William Faulkner

4
DSM-IV Criteria for Posttraumatic Stress
Disorder (PTSD)
  • A. Exposure to a traumatic event
  • Involved actual or threatened death or serious
    injury, or a threat to the physical integrity of
    self or others
  • Response involved intense fear, helplessness, or
    horror
  • B. Event is persistently re-experienced
  • C. Avoidance of stimuli associated with the
    event, numbing of general responsiveness
  • D. Persistent symptoms of increased arousal
  • Difficulty falling or staying asleep,
    irritability or outbursts of anger, difficulty
    concentrating, hypervigilance, exaggerated
    startle response

(American Psychiatric Association, 1994)
5
Neurobiological Changes in Response to Traumatic
Stress
  • Limbic System -- Hippocampus and Amygdala (Affect
    and Memory, e.g, Ledoux, 2000 van der Kolk,
    1996)
  • Neurotransmitters and Peptides (Numbing and
    Depression, e.g., Pitman, 1991, Southwick, 1999)
  • Changes in Hormonal System (HPA axis) (Arousal,
    e.g., Yehuda, 2000)

6
Pathways Between Trauma-related Disorders and
Substance Use
PTSD
SUD
TRAUMA
7
Pandora
  • The first woman, created by Hephaestus (God of
    Fire), endowed by the gods with all the graces
    and treacherously presented with a box in which
    were confined all the evils that could trouble
    mankind.
  • As the gods had anticipated, Pandora opened the
    box, allowing the evils to escape.

8
Clinical Challenges in the Treatment of Traumatic
Stress and Addiction
  • Abstinence may not resolve comorbid
    trauma-related disorders for some PTSD may
    worsen
  • Women with PTSD abuse the most severe substances
    and are vulnerable to relapse, as well as
    re-traumatization
  • Confrontational approaches typical in addictions
    settings frequently exacerbate mood and anxiety
    disorders
  • 12-Step Models often do not acknowledge the need
    for pharmacologic interventions
  • Treatment programs do not often offer integrated
    treatments for Substance Use and PTSD
  • Treatments for only one disordersuch as
    Exposure-Based Approaches are often marked by
    complications
  • treatments developed for PTSD alone may not be
    advisable to treat women with addictions

9
PTSD Treatment Approaches
  • Cognitive Behavioral
  • Prolonged Exposure in vivo imaginal
    conditioning theory (Foa Kozak, 1986 Cooper
    Klum, 1989 Keane, 1991 Foa, 1991)
  • SIT Stress Inoculation Training (Foa, 1991)
  • TREM Trauma Recovery and Empowerment (Harris,
    1998)
  • STAIR Skills Training in Affective and
    Interpersonal Regulation (Cloitre, 2002)
  • EMDR Eye Movement Desensitization and
    Reprocessing (Shapiro, 1995)

10
PTSD/SUD Integrative Treatments
  • Seeking Safety (Najavits, 1998)
  • ATRIUM Addictions and Trauma Recovery Integrated
    Model (Miller Guidry, 2001)
  • Not specifically designed for PTSD
  • TARGET - Trauma Affect Regulation Guidelines for
    Education and Therapy (Ford www.ptsdfreedom.org)

11
Comparison of Existing Trauma/ SUD- Focused
Treatment Research
12
Women, Co-occurring Disorders Violence Study
(SAMHSA)
  • Multi-site national trial (9 sites) examining
    implementation and effectiveness of treatment
    modalities for women with mental health,
    substance use and trauma histories
  • Core Treatment Components
  • Outreach and engagement
  • Screening and assessment
  • Treatment activities
  • Parenting skills
  • Resource coordination and advocacy
  • Trauma-specific services
  • Crisis intervention
  • Peer-run services

13
Spiral of Addiction and Recovery (Covington, 1999)
14
Do you think it is easy to change? Alas, it is
very hard to change and be different. It means
passing through the waters of oblivion.-D. H.
Lawrence, Change (1971)
15
Motivational Enhancement for Patients with
Comorbid PTSD Substance Use Disorders
16
Overview
  • What is it like to be ambivalent?
  • Why are motivation enhancement strategies
    promising ways to address these issues?
  • Basic philosophy and components of MI
  • MI example with a PTSD/SUD patient

17
aMbivAlenCe
18
Treatment Compliance
  • A general study of missed psychiatric
    appointments (Portland VA) found that those with
    PTSD and/or a SUD were most likely to miss
    appointments
  • Most studies of SUD treatment compliance have
    found that PTSD/SUD comorbidity is associated
    with poorer compliance

19
Why do we see these patterns?
20
Effects of Substance Use
  • Patients with PTSD/SUD report stronger substance
    use expectancies for tension reduction
  • Patients with PTSD/SUD report substance use helps
    to
  • facilitate social situations
  • get to sleep
  • deal with bad dreams and trauma memories
  • deal with negative emotions
  • enhance positive emotions

21
Other Challenges
  • Social isolation/alienation/lack of trust in
    others
  • Feelings of guilt or unworthiness
  • Shrinkage of world
  • Profound fear of own emotions and thoughts
  • Sleep disturbance/nightmares
  • Frightening re-experiencing symptoms
  • Foreshortened sense of the future (why bother)
  • Cognitive rigidity/poor attention capacities when
    stressed
  • Numb and unable to tap into reinforcers
  • Anger dyscontrol/irritability
  • Trauma anniversaries during first month of
    treatment
  • Disability/service connection issues (possibly)

22
How might a motivational enhancement approach
help those with PTSD/SUD comorbidity?
23
PTSD Treatment ModelStages of Recovery (Herman,
1992)
  • 1. SAFETY
  • 2. MOURNING
  • 3. RECONNECTION

24
PTSD Treatment Model MI
  • Solidifying motivation to engage in safety work
  • Safety and stabilization
  • Integration and mourning
  • Reclaiming or developing a meaningful life

25
MI Enhances TreatmentEngagement Among
OtherDually Diagnosed Individuals
  • Several studies have found that MI-oriented
    session(s) ranging from 1 to 9 contacts have
    helped improve
  • Aftercare initiation
  • Attending more treatment sessions

26
Basic MI Principles
  • Express empathy to convey understanding/acceptance
  • Develop discrepancy between current and desired
  • Avoid argument to limit resistance
  • Roll with resistance and use it for momentum
  • Support self-efficacy and belief that can change

27
Basic MI Tools OARS
  • Open-ended questions used to facilitate patient
    talking (yes/no ?s can bog down)
  • Affirmations used judiciously and sincerely to
    convey warmth and appreciation
  • Reflections simple, double-sided, amplified,
    unstated emotions used to facilitate further
    exploration
  • Summaries used to let patient hear their own
    words again and to convey understanding

28
Opening Constructively orBalancing Concerns
  • Ascertain patients understanding of session
  • Explain role
  • Orient to format and time
  • Elicit patients central concerns
  • Determine whether and how substance use is
    perceived to be a factor in concerns or problems,
    particularly with regard to PTSD symptoms

29
Using Feedback
  • Orient to feedback
  • Provide normative information for comparison
  • Use a neutral tone (nonjudgmental)
  • Gently reflect back surprise, disbelief, concern
  • Check whether information seems accurate
  • Avoid argument e.g., let disbelief go
  • Include range of relevant information (not just
    drug and alcohol)

30
Values Clarification or Developing Discrepancy
  • Goal is to help patient articulate what he/she
    holds dear and ascertain how current behaviors
    may or may not be barriers to achieving what
    he/she wants in life
  • Can use results of a values card sort to start
    conversation

31
Tipping the Balance TowardsChange
  • Pros and Cons of NOT changing alcohol or drug use
  • Pros and Cons of NOT changing PTSD-related
    behaviors (e.g., avoidance, anger behaviors)
  • Pros and Cons of changing alcohol or drug use
  • Pros and Cons of changing PTSD-related behaviors

32
Importance of making changes?
  • How important to client is addressing her PTSD?
  • How important is addressing her drinking?
  • How important is addressing her marijuana use?

1 2 3 4 5 6 7 8 9 10
Not at
Very all important
important
33
Confidence in ability to change?
  • How confident is client that she can change her
    PTSD?
  • How confident is she that she can change her
    drinking?
  • How confident can change her marijuana use?

1 2 3 4 5 6 7 8 9 10
Not at
Very all confident

confident
34
Menu of Options
  • Once patient has indicated that she/he is willing
    to consider making a change
  • Elicit options patient is familiar with
  • Ask permission to offer other options
  • Provide information regarding other options
  • Assist in sorting out viable option(s)
  • Elicit statement regarding follow through

35
Goals and how to get to them
  • Often useful to have written goal sheet that
    includes
  • Specific goal (or goals)
  • First few steps to achieve goal(s)
  • Reasons for making change
  • List of who can be helpful and how
  • Identify potential obstacles
  • Identify ways of dealing with obstacles

36
Important Feedback Mechanisms
  • Your clients in-session behavior is the central
    way to gauge whether you are dancing or wrestling
  • Your own emotional or gut reactions to what is
    happening in the session are also critical for
    staying on track
  • Listening to tapes of own sessions with or
    without rating
  • Supervision (group or individual) opportunities
    to provide outside feedback and ideas as well as
    to get support for taking this quieter, gentler
    path

37
How might Relapse Prevention help those with
PTSD/SUD comorbidity?
38
Seeking Safety (SS) vs. Relapse Prevention (RPT)
vs. TAU Outcomes PTSD Symptom Severity by
Treatment Group (N107)
Plt.01
Plt.01
Plt.01
All analyses adjusted for age and baseline PTSD
severity. End-of-Tx F4.71 (2,106), r2.42
3-month Post F4.94 (2,106), r2.28 6-month Post
F5.51 (2,106), r2.22. Findings reported in
Hien, DA, Cohen, LR, Litt, LC, Miele, GM
Capstick, C. (2004), Promising Empirically
Supported Treatments for Women with Comorbid PTSD
and SUD, American Journal of Psychiatry,
1611426-1432. Do not cite without permission of
the authors.
39
Seeking Safety (SS) vs. Relapse Prevention (RPT)
vs. TAU Outcomes Substance Use Severity by
Treatment Group (N107)
P.06
Plt.001
Plt.01
All analyses adjusted for age and baseline
substance use severity. End-of-Tx F6.01 (2,106),
r2.42 3-month Post F4.82(2,106), r2.36
6-month Post F2.87(2,106), r2.35. Findings
reported in Hien, DA, Cohen, LR, Litt, LC, Miele,
GM Capstick, C. (2004), Promising Empirically
Supported Treatments for Women with Comorbid PTSD
and SUD, American Journal of Psychiatry.
1611426-1432. Do not cite without permission of
the authors.
40
Relapse Prevention Treatment Why does it work
with PTSD?
  • Symptoms of SUD and PTSD that overlap
  • Emotion regulation problems that manifest in
    unstable temperament with expressions of anger,
    irritability, and depression

41
Maladaptive emotion focused coping
Affective lability
Biased information processing and problem solving
Emotion Regulation Deficits
Disruptions in attention, memory consciousness
Difficulties with intimacy and trust
Difficulty managing anger
Poor tolerance of negative emotional states
Behavioral Impulsivity
42
Complex Trauma and Addictions Underlying
Commonalities
  • Complex Trauma (DESNOS) is associated with
    repeated incidents (domestic violence or ongoing
    childhood abuse).
  • Broader range of symptoms self-harm, suicide,
    dissociation (losing time) problems with
    relationships, memory, sexuality, health, anger,
    shame, guilt, numbness, loss of faith and trust,
    feeling damaged.

43
Self-Perpetuating Cycle
Substance Use
Interpersonal difficulties, no anger management,
? isolation
Complicated Depression
? sleep disturbance irritability
44
Relapse Prevention Treatment
  • Assumptions of RPT
  • Substance abuse is a learned behavior
  • A habit that can be changed
  • Serves a function in their lives
  • Positive consequences
  • Negative consequences
  • Abstinence or harm reduction is possible
  • Difference motivation levels
  • A lapse is not relapse

G. A. Marlatt and J. R. Gordon (1985)
45
Characteristics of RPT
  • Active treatment for both clinician and client
  • Focus on current emotional and substance abuse
    issues and their connection
  • Identification of high risk situations
  • Coping skills
  • Triggers
  • Cravings
  • High risk situations
  • Practice skills through homework

46
Replace Addictive Behaviors
  • Learn new coping skills
  • Resisting social pressure
  • Increase assertiveness
  • Relaxation and stress management
  • Communication skills
  • Anger management
  • Social skills

47
Lifestyle Changes
  • Increase pleasant activities
  • Increase positive addictions and healthy habits
  • Short-circuit Seemingly Irrelevant Decisions

48
Seemingly Irrelevant Decisions
  • Skill Rationale
  • The most mundane choice can move you closer to
    using.
  • You are not just an innocent bystander in your
    life.
  • It just happened.I couldnt help it.
  • Promote accountability

49
Creating Safety
  • Although the world is full of suffering, it is
    full also of the overcoming of it.
  • Helen Keller

50
Seeking Safety
  • Developed as a group treatment for PTSD/SUD women
  • Based on CBT models of SUDs, PTSD treatment,
    womens treatment and educational research
  • Educates patients about PTSD and SUDs and their
    interaction
  • Goals include abstinence and decreased PTSD
    symptoms
  • Focuses on enhancing coping skills, safety and
    self-care
  • Active, structured treatment - therapist
    teaches, supports and encourages
  • Case management

Najavits, 2002 www.seekingsafety.org
51
NIDA Clinical Trials Network Women Trauma Sites
Washington Node Residence XII
Ohio Valley Node Maryhaven
New England Node LMG Programs
New York Node ARTC
Long Island Node Lead Node
South Carolina Node Charleston Center
Florida Node Gateway Community
Florida Node The Village
52
Treatment Groups
  • Seeking Safety (SS)
  • Short term, manualized treatment
  • Cognitive Behavioral
  • Focused on addiction and trauma
  • Womens Health Education (WHE)
  • Short term, manualized treatment
  • Focused on understanding womens health issues

53
Support
  • Participation in this study made possible by
  • NIDA CTN Long Island Regional Node
  • NIDA/NIH Grant U10 DA13035
  • We would like to acknowledge all of the staff and
    participants who made this study possible.

54
Participating Nodes and CTPs
Node Node PI(s) Protocol PI CTP Site PI Location
Florida Jose Szapocznik Daniel Santisteban Lourdes Suarez-Morales The Village Michael Miller Miami, FL
Florida Jose Szapocznik Daniel Santisteban Lourdes Suarez-Morales Gateway Community Candace Hodgkins Jacksonville, FL
New England Kathleen Carroll Melissa Gordon LMG Programs Samuel Ball Stamford, CT
New York John Rotrosen Marion Schwartz Addiction Research Treatment Corporation Robert Sage Brooklyn, NY
Ohio Valley Gene Somoza Greg Brigham Maryhaven Greg Brigham Columbus, OH
South Carolina Kathleen Brady Therese Killeen Charleston Center Mark Cowell Charleston, SC
Washington Dennis Donovan Betsy Wells Betsy Wells Residence XII Karen Canida Kirkland, WA
55
Project Directors/Protocol PIs
  • Frankie Kropp
  • Agatha Kulaga
  • Melissa Gordon
  • Chanda Brown
  • Silvia Mestre
  • Nadja Schreiber
  • Mary Hatch-Maillette
  • Chris Neuenfeldt
  • Cheri Hansen
  • Karen Esposito
  • Sharon Chambers

56
CTN-0015 Research Staff
  • Brianne OSullivan
  • Ileana Graf
  • Melissa Chu
  • Nishi Kanukollu
  • Treneane Salisbury
  • Rebecca Krebs
  • Ann Whetzel
  • Stella Resko
  • Carol Hutchinson
  • Chanda Brown
  • Janice Ayuda
  • Pamela Bernard
  • Jessica Ucha
  • Nicole Moodie
  • Allison Kristman-Valente
  • Lynette Wright
  • Melanie Spear
  • Lisa Johnson
  • Catherine Williams
  • Calonie Gray
  • Michele DiBono
  • Rachel Hayon
  • Barbara Bettini
  • Barbara Thomas
  • Lisa Markiewicz
  • Elizabeth Cowper
  • Rosaline King
  • Lara Reichert

57
CTN-0015 Clinicians
  • Lisa Cohen
  • Dawn Baird-Taylor
  • Lisa Litt
  • Martha Schmitz
  • Karen Tozzi
  • Darlene Franklin
  • Kathleen Estlund
  • Molly McHenry-Whalen
  • Erin Demirjian
  • Anslie Stark
  • Karen Bowes
  • Metris Batts
  • Felisha Lyons
  • Kathy McPherson
  • Victoria Johnson
  • Denese Lewis
  • Sharon Anderson-Goss
  • Merilee Perrine
  • Angela Waldrop
  • Leslie Lobel-Juba
  • Maria Mercedes Giol
  • Lourdes Barrios
  • Lisa Mandelman
  • Jeanette Suarez
  • Danielle Macri
  • Maria Hurtado
  • Tina Klem
  • Nancy Magnetti
  • Anne Marie Sales
  • Renee Sumpter
  • Michelle Melendez
  • Ida Landers
  • Regina Morrison
  • Clare Tyson
  • Mary Hodge-Moen
  • Sandra Free
  • Goldie Galloway
  • Karen Canida

58
CTN-0015 QA and Data Management
  • Jim Robinson
  • JP Noonan
  • Connie Klein
  • Karen Loncto
  • Chris Hutz
  • Lauren Fine
  • Michelle Cordner
  • Melissa Gordon
  • Maura Weber
  • Kristie Smith
  • Catherine Dillon
  • Donna Bargoil
  • Jurine Lewis
  • Girish Gurnani
  • Inna Logvinsky
  • Peggy Somoza
  • Sharon Pickrel
  • Katie Weaver
  • Molly Carney
  • Catherine Otto
  • Rebecca Defevers
  • Emily DeGarmo
  • Royce Sampson
  • Stephanie Gentilin
  • Clare Tyson
  • Anthony Floyd
  • Nathilee Francois

59
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