Pharmacy Group Birla Institute of Technology

1
Pharmacy GroupBirla Institute of Technology
SciencePilani
VISION 2008
Improvement of S T Infrastructure for Teaching
Research in Pharmaceutical
Sciences
Dr. R. Mahesh Group Leader (Head)
2
(No Transcript)
3
About the Group

• One of the earliest schools of Pharmacy Education
  and Research (1950)
• Mission Producing self-motivated and self
  reliant young pharmacists catering to the needs
  of Industry, Academia and Research
• Programmes Offered
• Bachelor of Pharmacy (Hons.)
• Duration 4 years
• Intake40
• Master of Pharmacy
• Duration 2 years ( 4 semesters )
• 12-15 every semester (37 on rolls)
• Doctor of Philosophy
• Duration Minimum 3 years (40 units)
• Full time research scholars- 12
• Faculty - 6

4
Special features of the Programmes

• Strong exposure to basic science, humanities,
  management and engineering related subjects
• Exhaustive exposure to various practical aspects
  of the research methodologies, instrumental
  techniques and industrial operations
• Option for doing projects (Study/ Laboratory/
  Computer oriented)from third year onwards along
  with regular courses, seminars, assignments etc.
• Unique option for choosing elective towards a
  specific career path
• Eight months Practice School (PS-I of 2 months
  and PS-II of 6 months)/ Thesis option under
  University Industry linkage programs
• Designed with the view of over all development
  rather than single area specialization
• Clinical, Industrial, Research, Regulatory
  Affairs, Management oriented syllabi

5
University-Industry Linkages

• Pioneers in Practice School concept (1973) PS-I
  and PS-II
• Functional at several National and International
  Industries and Research Organizations
• Industries
• Concept Pharmaceuticals Ltd, Aurangabad.
• Cadila Pharmaceuticals Ltd., Ahmedabad
• Torrent Research Centre, Ahmedabad
• Novartis Enterprises Pvt Ltd., Mumbai
• Dr. Reddys Lab., Hyderabad
• Dr. Morepan Labs, Chandigarh
• IPCA Labs, Mumbai
• Merind, Mumbai
• Srides Arcolabs, Bangalore
• Governmental and Other Agencies
• CDRI and ITRC, Lucknow
• Regional Research Laboratory, Jammu
• ICVD, Chennai
• B.V. Patel PERD Centre, Ahmedabad
• International Practice School Stations
• Ohm Laboratories, New Jersey, USA

6
Faculty

• Strength 19
• Professor- 02
• Associate Professor- 01
• Assistant Professor- 02
• Lecturer- 10
• Assistant Lecturer- 02
• Project Assistants- 02
• Faculty drawn from various disciplines across the
  Institute for basic courses
• Research Fellows Fulltime (12) Part time
  (06)
• Faculty Development Programmes
• Options for doing Higher degree or Doctoral
  degree for junior teachers
• Intensive teaching workshops
• Subject workshops and hands-on training
  programmes
• Faculty/Students Exchange and Training
  Collaborations
• USUHS, Bethesda, Maryland, USA
• CDRI and ITRC, Lucknow

7
Achievements

• Special Assistance Programme (SAP)
• Pharmacy group has got financial assistance under
  special assistance programme (SAP) of UGC at the
  level of Department Research Support (DRS)
• Financial assistance of Rs 32,60,000 for three
  years period
• National Awards
• Prof. M. L. Khorana Memorial Gold Medal for
  meritorious performance in
• B. Pharm. examination (1996, 1997, 1998, 1999,
  2000, 2002)
• G. P. Nair IDMA award for meritorious performance
  in
• B. Pharm. examination (1996-2002,2004)
• Prof. B. M. Mithal memorial Gold medal for
  meritorious performance in
• B. Pharm. examination (2001, 2002, 2003)

8
Extramural Research Grants ( Received in last
5 years)
9
Extramural Research Grants ( Received in last
5 years) (Contd)
10
Activities

• Human Resource Development for other
  Organisations
• Dr. Reddys Lab., Hyderabad M.Sc.(Tech.) in
  Pharm. Chem., M.S. (Pharm. Opn. Mgt.)
• L V Prasad Eye Institute, Hyderabad B.S., M.S.
  and M. Phil. in Optometry
• Shankara Nethralaya, Chennai B.S. and M. Phil.
  in Optometry, M.S. Medical Lab. Tech.
• Institute of Cardio-Vascular Diseases, Chennai
  B.S. and M. Phil. in Physician Assistant
• Pharmacy Dept., Kathmandu University
  Instrumentals Methods of Analysis
• Hetero Drugs, Hyderabad
• Srides Arcolabs, Bangalore
• Shashi Phytochemical industries, Alwar TQM,
  Validation and Documentation

11
Activities (Contd)

• Symposiums/ Workshops Organized
• International Symposium on Emerging Trends in
  Proteomics and Genomics Education and Research
  with Bio-Sciences Group (January 2003)
• 42nd IANCAS National Workshop on Radio Chemistry
  Applications of Radioisotopes in collaboration
  with BARC, Mumbai Bio-Sciences Group (December
  2000)
• National seminar on Direction of Pharmacy
  Education in the New Millennium as part of the
  Golden Jubilee Celebrations of Group (November
  2000)
• Indo-US Symposium workshop on Recombinant DNA
  Technology and its applications in Drug
  discoveries and Biotechnology with Bio-Sciences
  Group. (February 1999)
• Late Prof. B. M. Mithal Memorial Lecture (Since
  2001)
• Invited Lectures
• By eminent persons from Academic / Industry in
  the campus (at least 4 per semester)
• Invited lectures delivered by faculty in
  conferences/ other institutions- 9
• Conference papers (Last 2 years)
• International- 15 National- 22
• Journal papers (Last 2 years)
• International- gt25 National- 10
• Books published
• - Textbooks- 05 ,
• - Laboratory manual- 01

12
Laboratory and other facilities

• Central Analytical Laboratory
• Houses sophisticated analytical instruments- NMR,
  HPLC (2), GC, IR spectrophotometer, UV-visible
  Spectrophotometer (3), Spectrofluorimeter (2),
  Atomic absorption Spectrophotometer, High Voltage
  Electrophoresis, Gel Electrophoresis, Gel Drier,
  High Vacuum Lyophilizer, High efficiency ultra
  Centrifuges for gradient separation (2), and
  several other instruments
• Industrial Pharmacy Laboratory
• Facilities for pharmaceutical formulation
  manufacturing (tablets, capsules, ointments,
  liquid orals, parenterals) and in-process quality
  control procedures
• Formulation Development and Pharmacokinetics
  laboratory
• Facility for design and development of Novel and
  Controlled drug delivery systems
• Pharmacology and Physiology Laboratory
• Facility for screening and evaluation of NCEs
• Synthetic Medicinal Chemistry Laboratory
• Facility for design, synthesis and process
  optimisation of potential anti-psychotic,
  anti-microbial, anti-cancer, anti-viral and
  anti-inflammatory agents

13
Laboratory and other facilities (Contd..)

• Radio-Isotope Laboratory
• Facility for gamma scintigraphy, gamma
  spectrophotometry, Beta counter study of reaction
  kinetics using radio labelled probes and
  estimation of radio probes by atomic absorption
  spectrophotometer
• Molecular Biotechnology Laboratory
• Facility for nucleic acid and protein isolation
  and purification, rDNA manipulations, Cloning
  experiments, DNA sequencing, PCR, Gel
  Electrophoresis and Gel Documentation System
• Community and Hospital Pharmacy Practice
• (Services provided by the department at Medical
  Centre, BITS and Birla Sarvajanik Hospital,
  Pilani)
• Patient counselling
• Rational drug prescription monitoring and
  Evidence Based Practice
• Adverse drug effect/ reaction monitoring and
  reporting
• Therapeutic drug monitoring
• Patient clinics/ health awareness camps for
  Diabetes, Hypertension, Asthma and TB

14
Other Facilities

• Computational Facility
• PARAM 10000 super computer- Drug design and
  Bio-informatics
• WinNonlin- Pharmacokinetic modelling
• Alchemy- Molecular modelling and design
• ChemDraw- Synthetic medicinal chemistry
• Library Facility
• Caters to fast changing developments and
  academics or research needs of various programmes
  in the field of pharmaceutical sciences
• Caters to several national and internationally
  published journals/ scientific publications in
  the area of pharmaceutical sciences
  (International 09 and National- 05)
• Online e-Journal facility (J-portal and Science
  direct)
• Miscellaneous facilities
• Besides these, the Institute also has exceptional
  strength in the fields of microelectronics,
  digital systems, software development, flexible
  manufacturing systems, fiber optics, robotics,
  super-conductivity, solar energy, process
  control, power electronics etc.
• GOAL TO PROVIDE QUALITY EDUCATION FOR
  ECONOMIC ADVANTAGE

15
Focus of future research

• Design and development of new bioactive molecules
  (anti-inflammatory, anti-hypertensive,
  anti-convulsant, anti-psychotic, anti-bacterial,
  anti-viral,anti-AIDS and 5-HT, Dopamine receptor
  modulators)
• Screening and evaluation of NCEs, Receptor
  pharmacology and mechanism of action of drugs
• Development of pharmaceutical formulations and
  novel drug delivery systems
• Phamacokinetic studies
• Phytochemical investigations on selected natural
  products
• Pharmaceutical Analysis

16
Requirements

• Proposed Budget outlay (Amount in
  Lakhs)
• Creation of additional infra structural facility
  and modern sophisticated instruments / equipment
  for the development of the Pharmacy Group into
  A Centre of Excellence in Teaching, Research and
  Innovation in Pharmaceutical Sciences, requires
  aforementioned funds. Efforts are going on to
  meet the target and inputs are welcome in
• this regard.

17
Justification for the Need

• To create additional facilities for
• Training of students as well as research needs at
  the first degree (B. Pharm.) as well as higher
  degree levels (M. Pharm. and Ph.D.)
• Modern industrial manufacturing equipments as per
  latest GMP and ICH guidelines for training of
  students (UG PG) and fetching Industry
  sponsored projects in area of production process
  optimisation
• Providing extra thrust for research activities
• Development of pilot plant facility for
  optimisation of commercially viable synthetic
  process for NCEs
• Development of Biotech. based pharmaceuticals and
  over coming their stability problems
• Computational facilities for computer aided drug
  design and related activities
• Training of manpower in industry and academia

18
Current Research Activities

• Drug Design and Synthetic Medicinal Chemistry
• QSAR studies on metaloprotinase Inhibitors
• Application of QSAR and QSPKR concepts in design
  of NCEs with better biopharmaceutical profile
• Synthesis of pharmacological evaluation of novel
  5-HT Modulators for cancer chemotherapy induced
  emesis
• Design and synthesis of novel semi-carbazone
  derivatives as potential anti-convulsants
• Design and synthesis of novel non-nucleoside
  reverse trascriptase inhibitors for the treatment
  of AIDS
• Design, synthesis and biological evaluation of
  Indan derivatives as possible anti-inflammatory
  agents

19
Current Research Activities

• Formulation Development and Phamacokinetics
• Studies on design of novel ocular drug delivery
  systems for NSAIDs and antibiotics
• Enhancement of bioavailability of various drugs
  through phamacokinetics and formulation
  approaches
• Studies on design and development of controlled
  release combined dose formulations of
  anti-tubercular drugs
• Studies on design and evaluation of
  gastro-retentive formulation of selected drugs
• Studies on design and development of buccal drug
  delivery system
• Design and development of nano-technology based
  formulation for anticancer drugs

20
Current Research Activities

• Molecular Pharmacology and Drug Analysis
• Pharmacological implications of brain
  renin-angiotensin system modulators for novel
  therapeutic implications
• Studies on interface phenomenon in drug action
• Studies on novel interventions in alcohol
  withdrawal symptoms
• Screening of NCEs developed in in-house
  laboratory
• Analysis of drug in pure form, formulation
  matrices, biological matrices for invitro and
  invivo test samples using novel spectroscopic and
  chromatographic techniques
• Complete analytical profiling of new drug
  molecules physicochemical parameters, stability
  studies and drug excipient interaction studies

21
Thank You !!!