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Synaptic scaling in the

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The Neurosciences Institute. Neocortical cultures. Use pharmacology to manipulate activity ... Geoffrey Owens. Brandeis. University. Neurosciences. Institute ... – PowerPoint PPT presentation

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Title: Synaptic scaling in the


1
Synaptic scaling in the developing visual cortex
Niraj S. Desai Brandeis University The
Neurosciences Institute
  1. Cell Cultures
  2. Slices
  3. Slice Cultures

2
Neocortical cultures
  • Use pharmacology to manipulate activity
  • Measure effects on synaptic currents

3
Quantal currents
4
Synaptic scaling
  • Postsynaptic change in receptor density
  • Global and multiplicative rescaling
  • Slow time course (gt 12 h)

5
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7
Dark rearing modifies age effects
Control Dark-reared
8
Monocular deprivation
9
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11
C D
12
Channel infection in slice cultures
Johns et al. (1999) Burrone et al. (2002)
K channels
13
Summary
  • Slow form of homeostatic plasticity
  • Active in visual system development
  • Effects are age- and layer-specific

14
Acknowledgments
Gina Turrigiano Sacha Nelson Robert Cudmore
Brandeis University
Tanya Casimiro Geoffrey Owens
Neurosciences Institute
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