UpToDate

1
UpToDates Value Proposition

• UpToDate synthesizes the most recent medical
  information into evidence-based, practical
  recommendations clinicians trust to make the
  right point-of-care decisions.

2
UpToDate Facts-at-a-Glance

• 9,000 topics in 18 specialties
• Additional 5,000 unique drug entries
• 700 patient information topics
• 4,800 physician authors, editors and peer
  reviewers
• 7,700 graded recommendations
• 450,000 users in 149 countries

3
Specialties Covered in UpToDate
Infectious Diseases Nephrology and Hypertension
Neurology Obstetrics, Gynecology and Womens
Health Oncology Pediatrics Psychiatry
Pulmonary, Critical Care and Sleep Medicine
Rheumatology Surgery
In development

• Adult and Pediatric Emergency Medicine
• Adult Primary Care and Internal Medicine
• Allergy and Immunology
• Cardiovascular Medicine
• Dermatology
• Endocrinology and Diabetes
• Family Medicine
• Gastroenterology and Hepatology
• Geriatrics
• Hematology
• Hospital Medicine

4
UpToDate Is Trusted Worldwide

• UpToDate has users in

149 countries
5
UpToDates Editorial Process

• Authored and edited by leading physicians
• World-renowned expertise
• Hand-searching of 460 journals
• Three-tiered peer review process

6
UpToDates Editorial Process
Our authors collaborate withmultiple specialty
editors tocreate or update the topic.
New clinical studiesare released thatimpact
care.
The topic ispeer-reviewed.
UpToDateEditorial Process
Topic is available to clinicians worldwide
via UpToDate.
A gradingeditor reviewsthe gradedrecommendation
s.
Final topic contentconsensus is reached.
7
Graded Recommendations
Grades denote strength of recommendation and
quality of evidence

• Strong recommendation Grade 1 We
  recommend
• Weak recommendation Grade 2 We suggest
• Evidence Grade A, B or C High, moderate or
  low quality

8
Graded Recommendations

• Hierarchy of Evidence

High - Quality Low - Quality
Meta-analyses of randomized trials of high
methodological quality Randomized trials with
methodological limitations Observational
studies Unsystematic clinical observations
9
Users SayUpToDate Improves Care
94 improves quality of care
89 changed management
81 changed diagnostic testing
0
20
40
60
80
100
Source UpToDate Subscriber Survey, 2010
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Medical ProfessionalsEndorse UpToDate
UpToDate changes the wayyou practice medicine
really.

• Pam Wetzel, MD
• Chief Medical Information OfficerSwedish
  American Hospital, Rockford, IL

11
Medical ProfessionalsEndorse UpToDate
UpToDate applicability to patients is in
evidence every day.

• Marc Greenwald, MD
• Chief of MedicineSignature Healthcare-Brockton
  Hospital, Brockton, MA

12
Medical ProfessionalsEndorse UpToDate
UpToDate is a new way of practicing medicine
for day-to-day practice there is no other
product.
R.M. Valentijn, MDMDHAGA Hospital, the Hague, the
Netherlands