Green Coffee Antioxidant

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Green Coffee Antioxidant
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GREEN COFFEE ANTIOXIDANT

• Specifications
• All Natural
• 100 green coffee beans
• Contains gt 65 Active Polyphenols
• Contains gt 50 Chlorogenic Acid
• Caffeine level lt 4
• Highly Soluble
• Neutral Taste Profile

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GREEN COFFEE ANTIOXIDANT
Market Analysis

AFS GCA
Other Coffee Extracts

• Standardized to 50 Chlorogenic Acid-CA
• Price / 150 mg CA .0435
• Intellectual Property Protected
• GRAS Status
• 3 Step purification process (water/alcohol)
• Advanced Analytical Methods of Analysis

• Product Quality ranges from 15 to 50
  Chlorogenic Acid-CA
• No specific standard of identity in method
  analysis
• Price / 150 mg CA .105 (mkt. average)
• Variations in product consistency / quality

No patents pending
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GREEN COFFEE ANTIOXIDANT

• Applications
• Powerful Antioxidant
• LDL Oxidation Reduction
• Free Radical Neutralization
• Blood Glucose Management
• Control Carbohydrate metabolism
• Decrease fatty acid synthesis

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GREEN COFFEE ANTIOXIDANT

• Bioavailability
• Proven in multiple human studies
• Readily bioavailable
• Not destroyed in the stomach

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GREEN COFFEE ANTIOXIDANT

• Antioxidant Strength
• 5-8 times higher antioxidant capacity
• No reduction in other critical antioxidants
• Shown to top the hierarchy of antioxidants
  (utilized first)

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GREEN COFFEE ANTIOXIDANT
Quality of the antioxidants was measured by a
dose-response in vitro model of lipoprotein
oxidation
7.3
8
7
6
5
4
Quality of Antioxidants
3.1
3
1.9
1.4
1.4
2
1.2
1
0
Coffees
Black Teas
Green Teas
Red Wines
Vegetables
Fruits
Vinson, 2003
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GREEN COFFEE ANTIOXIDANT

• GI reduction/blood sugar
• balancing
• Reduced GI of white bread and glucose 24 in
  healthy humans
• Reduced blood sugar levels as much as 31 in
  healthy humans
• Applications
• Glucose management
• Reduction of calorie absorption
• Enhancing carb restrictive diets

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GCA IN GLUCOSE MANAGMENT

• Two specific mechanisms utilizing chlorogenic
  acids in blood glucose regulation
• Reduce total carbohydrate absorption within the
  Absorptive (feeding) state
• (inhibiting the enzymatic process)
• Reduce the activity of the Glucose-6-Phosphatase
  Pathway during Post-Absorptive (fasting) state
• (G-6-P translocase)

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Principle Pathways During Absorptive
StateDuring the feeding state ingested carbs
are converted to simple sugars where 80 feed
respiration, the balance is stockpiled in the
liver as glycogen stores, when glycogen storage
is full the simple sugars are converted to fat
storage in the body.
GI Tract
Blood
Liver
Carbs- Glucose Fructose Galactose
Glycogen
FAT
Glucose
(80)
Energy Needs
Hyper- Glycemic Peak
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Principle Pathways During Absorptive
StateDuring the feeding state chlorogenic acid
acts as a regulator on the simple sugars allowing
for only enough into the bodys GI system for
cellular respiration and glycogen storage,
reducing the ability of excess carbs and sugars
to get stored as fat and trigger insulin activity.
GI Tract
Blood
Liver
Carbs- Glucose Fructose Galactose
Glycogen
FAT
Glucose
(80)
Chlorogenic Acid (reduces the total amount
of Carbohydrates absorbed in the Small intestine)
Energy Needs
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Principle Pathways During POST-Absorptive
State During fasting, when our bodies are
resting and we are not ingesting foods, the
glycogen stores reserved in the liver are
depleted to provide our bodies with simple sugars
for cellular respiration. When blood glucose
levels trigger insulin the level of glycogen
converted back into glucose slows down
Insulin
GI Tract
Liver
Blood
Carbs- Glucose Fructose Galactose
Glycogen
FAT
Glucose
(80)
Energy Needs
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Principle Pathways During POST-Absorptive
State Insulin activity triggers glycogen storage
into cellular fat storage. Chlorogenic acid has
the ability to regulate the level of glycogen
back into glucose to minimize spikes in insulin
activity and regulate the bodys blood glucose
levels more efficiently esp. in those who have
difficulty regulating the primary glucose
pathways on their own.
X
Insulin
X
GI Tract
Liver
Blood
X
Carbs- Glucose Fructose Galactose
X
Glycogen
FAT
Glucose
(80)
Chlorogenic Acid
Energy Needs
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GREEN COFFEE ANTIOXIDANT

• Human Clinical Evidence
• Abidoff et al.
• approx 175 mg of GCA (equiv)
• reduced blood sugar levels 20
• Johnson et al.
• approx 300mg of GCA (equiv) reduced insulin
  response gt40.
• Fields et al.
• 300 mg of GCA reduced peak blood sugar 29 and a
  total of 24.
• Four cohort studies-JAMA, Harvard, Lancet,
  (gt30,000N) type II diabetes was prevented
  gt50 with coffee consumption

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GREEN COFFEE ANTIOXIDANT

• Claims
• May reduce the Glycemic Index of carbohydrate
  based foods.
• May reduce the rate of glucose adsorption.
• May block the adsorption of carbohydrates and
  calories from carbohydrate based foods.
• May help maintain healthy blood sugar levels
  already in a healthy range.
• May induce the utilization of fat as an energy
  source during fasting.

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GREEN COFFEE ANTIOXIDANT

• Food and Beverage Benefits
• Highly Soluble
• Good Taste Profile
• Relatively low cost/dose
• Cost effective solution for weight management
  ingredient
• GRAS (generally recognized as safe)

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GREEN COFFEE ANTIOXIDANT

• Dosage Recommendations
• 300 mg GCA achieves 25-30 reduction in total
  blood sugar.
• Taking with meals is optimum way to minimize
  caloric impact and spiked blood sugar levels (ie.
  3 x per day).
• For antioxidant benefits, 150-200mg equates to
  technical data.
• May induce the utilization of fat as an energy
  source during fasting.