Dr Motlalepula G' Matsabisa

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• Dr Motlalepula G. Matsabisa
• Indigenous Knowledge Systems Health
• Medical Research Council South Africa
• Portfolio Committee on Health
• April 11th 2004

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Our Mission and Vision To
promote and advance indigenous knowledge systems
through research and development by making it a
valued health model in the global environment and
to redress health traditions, which until now
have neglected health research priorities and
issues. To be a centre of excellence in
traditional medicines research regionally and to
be competitive globally
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Objectives

• Coordination and development of health research
  in indigenous knowledge
• Institutional and community networks
• Development of an enabling clinical trial
  environment
• Innovations and commercialization in
  traditional health systems.
• Policies governing intellectual property and
  benefit-sharing
• Research programmes that are appropriate
  relevant
• Support academic research
• Funding

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Current Projects
IKS Research and Development
IKS Knowledge Management
IKS Utilization (SBU)
Research
Policy
Database
Special Projects
DELFT CENTRE
MALARIA
IK TRUST
TRAMED III

• Medicinal Garden Project
• Training Programme

ACCESS BENEFIT-SHARING
HYPERTENSION
School outreach program
HIV AND AIDS
NHKN
IKS RESEARCH GUIDELINES
TUBERCULOSIS
CLINICAL TRIALS PLATFORM



IP POLICY
TRADITIONAL HEALERS
FARM
CANCER
TDr Program
MCC - ATMC
PAIN
MONONGRAPHS
NATIONAL REFERENCE CENTRE for ATM
POVERTY ALLIVIATION
DIABETES
TRADITIONAL HEALTH CLAIMS
TOXICOLOGY
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Agreements

• Signed between TDr,
  Individuals and MRC on Collaborative Research
• Traditional Immune Boosters
  Antihypertensive
• - Eastern Cape (2)
  - North West
• - North West
• - KwaZulu/Natal
• - Gauteng (3)
• - Limpopo
• Traditional Cure for Breast Cancer
  Anti -Tuberculosis
• - Gauteng
  - North West
• 
  - Gauteng
• Traditional Antidiarhoeal
• - KwaZulu/Natal
• Traditional Antimalarial
  International
  agreements
• - Free State, KwaZulu/Natal
  - Tanzania Immune
  modulator Antidiabetic
• 
  -
  Uganda Antidiabetic, antihypertensive
• Traditional Antidiabetic
  - Nigeria University
  of Ibadan

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Malaria

• Preclinical studies
• Clinical studies

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C30H28O6
C30H28O7
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Antimalarial activity
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Resistance Modulators
Cancer Antibiotics Malaria HIV and AIDS
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Anticancer

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Antidiabetic
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HIV and AIDS

• Assessment of Traditional Claims for cures
• Safety, Efficacy studies
• Value addition

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Clinical Trials

• Ethics
• Ethics Informed consent for screening
• Informed consent for HIV testing
• Informed consent for
  participation in the study
• Information leaflet for the
  screening
• Information leaflet for
  participation in the study
• Counseling
• Integrated approach To whole
  family
• Pre-screening HIV
  counseling
• 1 post screening counseling (referral of
  those that are HIV, but not meeting the
  inclusion criteria to appropriate accredited
  centres for support)
• Ethical approval (scientific and ethical
  merits)
• Protocols are peer-reviewed
• Submitted to MRC MCCs Clinical Trials
  Committee (CTC) for ethical evaluation

• Toxicology
• 90-day sub chronic study on a non-human primate
  model

• Clinical Human Trials
• Both Phase I and II/III
• Are double blind, randomized, placebo controlled
  dose elevation parallel group studies

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Case Studies
Extract A SO 86 Extract B PT
96 Extract C Cm g 86
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HIV and AIDS

• Training
• School Outreach
• Community Partnership
• Medicinal Herb Garden

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MRC Delft Community Project

• Provide enabling environment for healers and
  scientists to interact
• Formal structure for healers to interact, develop
  policy and develop communication products
• Provide healers access to scientific
  infrastructure (Information, Library, Internet
  access, database, medicinal plant cultivation,
  drug discovery, Resource Centre)
• Provide a forum for structured health education
  and promotion (Herb garden)
• Develop skills in growing, processing, packaging
  and marketing of herbal products

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School out-reach Program and TDr Training
Program photos not included
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IKS Utilization

• Strategic Business Unit
• Socio-economic Development
• Poverty Elimination
• Manufacturing

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Poverty Elimination
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Organizational Structure
DST
Health Education
MRC
Agriculture
Skills transfer
Skills transfer
Entrepreneurial skills development
Community
Commercial Partner
Municipality
Skills transfer
Business development
Infrastructure
Land
Markets
Nursery
Commercial farming
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MethodologyTHE VALUE ADDED CHAIN

• Creation
  (Patents, Innovations)
• Knowledge
  
• Point of entry Existing Industries
  Services
• 
  ________________________________________________
  _
• Industries
• Point of entry Emerging Industries
  
• Agriculture

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Theoretical model

• 
  MARKET

Commercial viability (2)

• INSTITITONAL
• SUPPORT
• (1)
• MRC
• Municipalities
• Private sector

• INDUSTRY
• (5)
• Partnerships

Technical viability (3)
Entrepreneurial viability (4)
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Kimberley
Municipality Senqu Place Sterkspruit
Municipality Tsolwana Place Hofmeyer/
Tarkastad
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Anticipated Impact
Job creation Sustainable use of medicinal
plants Application of scientific research
developed by the IKS Lead Programme Capacity
building for institutions (municipalities) Traini
ng and promotion of the culture of
entrepreneurship The promotion of registered
business ventures fully owned by emerging
entrepreneurs Horizontal and vertical
integration of the area surrounding the projects.
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IKS Technologies

• Systems Mechanisms of Action
• Analytical analysis
• Quality Control
• Manufacturing

• Proteomics
• Genomics
• Metabolimics
• Cytochrome P540
• 1a2
• 2a
• 2c19
• 2d6
• 2c8
• 2c9
• 2e1
• 3a4

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International Collaboration

• Tanzania Immune modulator Antidiabetic
• Uganda Antidiabetic, antihypertensive
• Nigeria University of Ibadan
• US Rutgers
  University N.J - Antimalarial
• Kenya KEMRI KETRI
• Botswana UB, Chemistry BOTEC
• Lesotho - Ministry of Health
• USHEPiA University Science, Humanities,
  Engineering Partnerships in Africa

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Conclusion

• To support the mission and vision of MRC and
  support National Programmes on Health, science
  and Technology
• Seek increased baseline support from MRC if IKS
  is to make and impact
• seek a baseline funding of R2
  million per year
• - Requesting R2,5 million for
  infrastructural development at
• Delft ( Match up R4 million
  from DST for equipment)
• Increase the science staff complement in IKS
• To get science to benefit our communities
• To develop and manage partnerships and consortia
  effectively (African Initiative on Traditional
  Medicines, Indian Traditional Medicines, WHO Afro
  scientific advisory committee)
• To be a centre of excellence in Traditional
  Medicines research
• Capacitated GP (clinical trials), Traditional
  healers (Training, knowledge transfer, IP,
  Commercialization), Communities (poverty
  reduction, business skills, community
  enterprises), Scientists (State of the art
  equipment and research)
• Empowerment (CPPP), Business development, BEE,
  spin out companies

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How to Contact Us

• Indigenous Knowledge Systems Health Lead
  Programme
• Dr MG Matsabisa Director
• Tel. [phone]
• Fax. [phone]
• E-mail. Motlalepula.matsabisa_at_mrc.ac.za
• Website www.mrc.ac.za

Going back to our roots for innovative health
solutions