An Introduction To The Health Effects of Lead

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An Introduction To The Health Effects of Lead
A Small Dose of Lead
Steven G. Gilbert, PhD, DABT www.asmalldoseof.org
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Child Health
Recycling Lead
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Toxicology Definitions
The study of poisons or the adverse effects of
chemical and physical agents on living organisms.
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Environmental Health
Conditions that ensure that all living things
have the best opportunity to reach and maintain
their full genetic potential. Steven G.
Gilbert, 1999
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What do these have in common?

• Hong Kong
• Princess Diana
• Ambassador to Mexico
• Coeur dAlene, Silver Valley, ID
• Tacoma
• 100 Billion, 65 Billion
• Food, noise, dust
• 11,000 to 689,000 Children

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What Is This?
O
CH3
CH3
N
N
7
1
3
N
O
N
CH3
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Key Words
Dose / Response

• Risk
• Hazard X Exposure

Individual Sensitivity
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Paracelsus
All substances are poisons there is none which
is not a poison. The right dose differentiates a
poison from a remedy. Paracelsus (1493-1541)
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An Individual View
The sensitivity of the individual differentiates
a poison from a remedy. The fundamental principle
of toxicology is the individuals response to a
dose. S. G. Gilbert (1997)
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Neuron
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What Is This?
(CH3-CH2-OH)
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Effects of Prenatal Alcohol
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FAS Child
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Effects of Amount on Response
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Effects of Size on Response
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Half-life
How Long It Takes To Go
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12
10
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Concentration (µg/ml)
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4
2
0
0
1
2
3
4
5
6
7
8
9
10
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Time (hrs)
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Lead In Homes
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Lead in Families
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Ancient Awareness

• 6500 BC. - Lead discovered in Turkey, first
  mine.
• 500 BC-300 AD.- Roman lead smelting produces
  dangerous emissions.
• 100 BC. - Greek physicians give clinical
  description of lead poisoning.

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Ancient Awareness
"Lead makes the mind give way."
Greek Dioscerides - 2nd BC
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Historical Awareness
If we were to judge of the interest excited by
any medical subject by the number of writings to
which it has given birth, we could not but regard
the poisoning by lead as the most important to be
known of all those that have been treated of, up
to the present time.
Orfila, 1817
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L. Sullivan, 1991
Lead Poisoning remains the most common and
societal devastating environmental disease of
young children.
Public Health Service - L. Sullivan, 1991
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Lead Based Paint Products
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Lead Based Paint
1887 - US medical authorities diagnose childhood
lead poisoning 1904 - Child lead poisoning linked
to lead-based paints 1909 - France, Belgium and
Austria ban white-lead interior paint 1914-
Pediatric lead-paint poisoning death from eating
crib paint is described 1921 - National Lead
Company admits lead is a poison 1922 - League of
Nations bans white-lead interior paint US
declines to adopt 1943- Report concludes eating
lead paint chips causes physical and neurological
disorders, behavior, learning and intelligence
problems in children 1971- Lead-Based Paint
Poisoning Prevention Act passed
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Lead In Gasoline
1854 - Tetraethyl lead discovered by German
chemist 1921 - Midgley discovers that tetraethyl
lead curbs engine knock 1922 - Public Health
Service warns of dangers of lead production,
leaded fuel 1923 - Leaded gasoline goes on sale
in selected markets 1936 - 90 percent of gasoline
sold in US contains Ethyl 1972 - EPA gives notice
of proposed phase out of lead in gasoline. 1986 -
Primary phase out of leaded gas in US
completed 1994 - Study shows that US blood-lead
levels declined by 78 percent from 1978 to
1991 2000 - European Union bans leaded gasoline
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History Of Lead Toxicology
Investigator Date Blood Findings Dioscerides 2n
d BC 100 "Lead makes the mind give way." B.
Franklin 1763 100 "Dry gripes" A.J.
Tuner 1894 80 Childhood plumbism R.
Byers 1943 80 Long-term sequelae CDC 1973 40 U
ndue lead exposure CDC 1975 30 Undue lead
exposure CDC 1985 25 Undue lead
exposure WHO 1986 20 Undue lead
exposure EPA 1986 15 Undue lead exposure Fulton
et al. 1987 15 IQ Deficits Hansen et
al. 1987 15 IQ Deficits CDC 1990 10 Undue lead
exposure
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Agency Blood Lead Levels
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Sources Of Lead

• Lead Paint
• Dust, Soil
• Water
• Industry
• Hobbies
• Traditional Ethnic Remedies

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Lead Out of Gasoline
1990 lead removed from Gasoline Between 1976
and 1994, the mean blood lead concentration in
children dropped from 13.7 mcg/dL to 3.2
mcg/dL One of the major public health triumphs
of the 20th century
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Lead - Absorption
Orally Consumed Lead Absorbed In Place of
Calcium CHILDREN 30-50 OF LEAD ADULTS 5-10
OF LEAD Increased During Pregnancy
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Lead - Nutrition
NUTRITIONAL DEFICIENCIES INCREASE ABSORPTION
(high fat diets, iron, calcium) VITAMIN D (from
sun) INCREASES
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Half-life Of Lead
25 DAYS -- BLOOD 40 DAYS -- SOFT TISSUE 20
YEARS -- BONE
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Children Vulnerability
CHILDREN are more vulnerable exposure than
ADULTS Size Consume More Food Inhale More
Air Developing Nervous System Increased need for
Calcium
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Health Effects

• Encephalopathy
• Colic
• Frank Anemia
• Hemoglobin Synthesis
• Peripheral Neuropathies
• Infertility (MEN)
• Systolic Blood Pressure (MEN)
• Nerve Conduction Velocity
• Erythrocyte Protoporphyrin
• DEVELOPMENTAL TOXICITY
• IQ, Memory, Learning
• Growth

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Needleman, NEJM, 1979
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CHILDREN ADULTS
Blood Lead
(ug Pb/dl)
150
Death
Encephalopathy
100
Encephalopathy
Frank Anemia
Nephropathy
Frank Anemia
Decreased Longevity
Colic
Hemoglobin Synthesis
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Peripheral Neuropathies
Infertility (MEN)
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Hemoglobin Synthesis
Nephropathy
Systolic Blood Pressure (MEN)
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Vitamin D Metabolism
Hearing Acuity
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Nerve Conduction Velocity
Erythrocyte Protoporphyrin
Erythrocyte Protoporphyrin
(Women)
Vitamin D Metabolism(?)
DEVELOPMENTAL TOXICITY
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Hypertension (?)
IQ
HEARING
Transplacental Transfer
GROWTH
- Low birth weight
- Miscarriages, Stillbirth
- Premature birth
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Reproductive Effects Of Lead

• WOMEN
• lead crosses the placenta
• low infant birth weight
• retarded mental development
• miscarriages
• premature birth
• stillbirth
• MEN
• decreased sex drive
• impotence
• sterility
• altered sperm-birth defects

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Childhood Lead Exposure
-- LONG TERM PROBLEMS --
LOW GRADES ABSENTEEISM READING
DISABILITY HIGH SCHOOL DROP OUT
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Academic Social Costs Of Lead Exposure

• Increased risk of not graduating from high school
  (rr 4.8)
• Poorer reading scores
• Increased evidence of depression
• Higher rate of hard drug use
• Increased risk for attention deficit disorder
• Increased risk for antisocial behavior

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Cost of Childhood Lead

• Assumptions in calculating costs
• All lead is harmful and from environment
• Blood lead of children age 5 2.7 ug/dl (CDC)
• 5-year old boys (1,960,200) and girls (1,869,800)
• 1 ug/dl of lead 0.25 IQ point reduction
• Cost boys 27.8 and girls 15.6 Billion
• Total Costs 43.4 Billion

Environmental Pollutants and Disease in American
Children Estimates of Morbidity, and Costs for
Lead Poisoning, Asthma, Cancer, and Developmental
Disabilities, by Landrigan, P. et al. EHP, 110,
July 2002, 721-728.
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Agency Blood Lead Levels
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Lead in Water - regulation
What are the legal limits regarding lead and
drinking water? Lead and copper are regulated by
a treatment technique that requires systems to
control the corrosiveness of their water. If more
than 10 of tap water samples exceed the action
level of 15 parts per billion, water systems must
take additional steps to reduce corrosivity.
EPA - http//www.epa.gov/safewater/lead/leadfacts
.htmlconcerned
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Lead - References
EPA Lead site the best http//www.epa.gov/oppt
intr/lead/index.html
CDC Childhood Lead Poisoning Prevention Program
http//www.cdc.gov/nceh/lead/lead.htm
A Small Dose of Toxicology lead chapter A
Small Dose of Lead http//www.asmalldoseof.org/t
oxicology/lead.html
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A Small Dose of Lead
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Authorship Information
This presentation is supplement to A Small
Dose of Toxicology
For Additional Information Contact Steven G.
Gilbert, PhD, DABT E-mail smdose_at_asmalldoseof.org
Web www.asmalldoseof.org
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Knowledge - Responsibility

• Children have a right to a safe, fair and healthy
  environment
• Ethical Responsibility to share and use of
  knowledge
• Duty to promote health and well being of children
• Thoughtful public health advocate

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Lead in Jewelry
California Suing Major Retailers Over Lead in
Jewelry Allegations California is suing 13 major
retailers alleging they broke state law by not
warning customers that some of their jewelry
contains lead. Private lawsuits containing
similar allegations have been filed against a
further 11 retailers. Named in the state's suit
were Macy's, Target, Wal-Mart, Kmart, J.C.
Penney, Mervyn's, Nordstrom, Ross, Sears,
Express, Claire's, Toys "R" Us and Burlington
Coat Factory, along with some of their affiliates
and parent companies, according to The San Jose
Mercury News. (June 24, 2004)
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Lead in Jewelry
http//www.leadinspector.com/
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Common Lead Uses

• Lead acetate (Pb (C2H3 O2)2 3H2O)
• White, crystalline substance
• Sugar of lead has a sweet taste
• Paint
• Lead tetraethyl (Pb(C2H 5)4)
• antiknock compound added to gasoline
• significant contributor to air pollution

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Take Home Lead Exposure
California, 1998 Lead poisoning in furniture
workers and their families Father 46 µg/dL
18-month-old child BLL 26 µg/dL 4-month-old
daughter BLL 24 µg/dL two refinishers BLLs of 29
and 54 µg/dL, the four carpenters BLLs of 46,
46, 47, and 56 µg/dL.
MMWR - April 06, 2001 / 50(13)246-8
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Lead Contaminated Town
Herculaneum, Missouri Doe Run Lead
smelter 160,000 tons of lead per year One of the
largest lead smelters in US Past over 800 tons of
lead released into the environment as part of the
smelting process. Reduced to 81 tons in 2001
Target is 34 tons in 2002.
NY Times, Jan 19, 2002
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Children Affected
16 of all American children Children with blood
leads above 15 UG/DL 7 of economically favored
white children 55 of African American children
in poverty source The nature and extent of
lead poisoning in children in the US a report
to Congress - ATSDR
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Mechanisms Of Lead Toxicity

• Lead-Calcium Interactions
• Lead-Protein Interactions
• Lead-Dopamine Systems Interactions
• Lead-Opioid Systems Interactions

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Lead Chelating

• EDTA, Bal, Succimer
• EDTA In Use For 48 Years
• Little Knowledge Of Benefits Or Hazards Of These
  Drugs
• The Treatment Is Removing The Source Of Lead

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Lead In Ethnic Remedies
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Why Screen For Lead Exposure
Test siblings Find the source Reduce risky
behaviors Education about the hazards Education
about nutrition
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Recycling Lead
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Truth and Lead
How long a useful truth may be known and exist,
befort it is generally receivd and practisd
on Benjamin Franklin