Systemic Lupus Erythematosus: Causes, Symptoms, Daignosis, Prevention and Treatment

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Systemic Lupus Erythematosus
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Systemic Lupus Erythematosus

• Systemic Lupus Erythematosus (SLE) is a kind of
  disease that is a good example of an autoimmune
  disease. It is a chronic inflammatory disease
  where the immune system attacks the tissues of
  different organ systems throughout the body and
  can result in many problems.Overall, this
  disease occurs to a frequency of about one in
  1000. It is most common in women, particularly in
  the fertile years. In these years this disease
  has a ratio of about 9 women to 1 man, while in
  other years the ratio is much closer.There are
  various manifestations of systemic lupus ranging
  from mild to life threatening. The most common
  symptoms of this disease include

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Systemic Lupus Erythematosus
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• rash (with a butterfly rash occurring on the
  face being common) sun sensitivity arthritis
  mouth and other mucous membranes sores
  pericarditis (inflammation around the lining of
  the heart) pleurisy (inflammation around the
  lining of the lungs) a tendency to form blood
  clots a tendency for blood vessels to get
  inflamed seizures renal disease which can further
  lead to kidney failure and dialysis blood
  abnormalities, etc.Because of the many
  different manifestations, this can be a very
  difficult disease to diagnose. Blood tests are
  helpful. Mostly, rheumatologists are consulted to
  help and confirm the diagnosis. Because of the
  difficulty in treating some of these problems
  they are also needed to take part in the
  management of this disease.

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• The cause of systemic lupus erythematosus (SLE)
  is still not known. There lies a genetic
  predisposition to it, and can be triggered by
  environmental exposures. Because of these genetic
  influences, this disease is more common in some
  parts of the world than in others.Many patients
  are available that can be very sensitive to the
  sun, and sunlight can trigger diverse elements of
  the disease, such as renal disease.Still,
  systemic lupus erythematosus (SLE) has no cure,
  but there are some medications that are available
  and it helps to manage its varied
  manifestations.

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• Few of the medications that can be used for the
  treatment of systemic lupus erythematosus (SLE)
  include relatively mild medications like
  plaquenil, medications for pain, varying doses of
  glucocorticoids (such as prednisone) which often
  results in many adverse effects and
  immunosuppressive (such as chemotherapeutic
  agents) which need careful monitoring.It is
  very difficult to believe but there has been no
  new drug approved for the treatment of systemic
  lupus for past several decades. This is in part
  because of the many problems of the disease. It
  is difficult to find patients with similar
  manifestations who have a similar activity to
  their disease.This is needed to prove that a
  medication is effective. This is why it is so
  important to continue to look for new treatments
  in systemic lupus erythematosus (SLE). A new
  medication may be approved for use in systemic
  lupus erythematosus (SLE) soon, but much needs to
  be done.

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